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Methods to Characterize Nanoparticles for Mucosal Drug Delivery

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Book cover Mucosal Delivery of Drugs and Biologics in Nanoparticles

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 41))

Abstract

Physicochemical properties of the nanoparticles are associated to their in-vivo behavior including pharmacokinetic, bio-distribution, efficacy, and toxicity profiles. It is imperative to gain a comprehensive understanding of the nanoparticle properties through their characterization. Characterization of nanomaterials depends upon their unique physical and chemical properties with different level of complexity at molecular levels. Distinct properties of nanoparticles often hinder when standard methods of characterization of particles are used, which compromise the reliability and reproducibility of the outcome. Nano-therapeutics characterization depends on various aspects, including the encapsulated drug, delivery vehicles, disease, route of administration, dosing amount and its application. The precise control over nanoparticle properties need robust and advanced characterization techniques. Generally, characterization of nanoparticles is based on the composition, size- distribution, morphology, surface charge, purity and stability, using sophisticated techniques such as dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM) etc. Mean particle size, morphology and surface charge of nanoparticles affect their physical stability, re-dispersibility and in-vivo biodistribution. This chapter summarizes the basic principles, associated challenges and practical concerns in standard and promising physicochemical techniques used for characterization of nanoparticles.

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Authors and Affiliations

  1. Institute of Nano Science and Technology (INST), Mohali, Punjab, India

    Kalpesh Vaghasiya, Ankur Sharma, Eupa Ray, Suneera Adlakha & Rahul Kumar Verma

Authors
  1. Kalpesh Vaghasiya
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  2. Ankur Sharma
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  3. Eupa Ray
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  4. Suneera Adlakha
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  5. Rahul Kumar Verma
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Corresponding author

Correspondence to Rahul Kumar Verma .

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Editors and Affiliations

  1. Department of Pharmaceutical Sciences, College Pharmacy, University of New Mexico, Albuquerque, NM, USA

    Pavan Muttil

  2. Department of Pharmaceutical Sciences College of Pharmacy and Health Sciences, St. John’s University, Jamaica, NY, USA

    Nitesh K. Kunda

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Vaghasiya, K., Sharma, A., Ray, E., Adlakha, S., Verma, R.K. (2020). Methods to Characterize Nanoparticles for Mucosal Drug Delivery. In: Muttil, P., Kunda, N. (eds) Mucosal Delivery of Drugs and Biologics in Nanoparticles. AAPS Advances in the Pharmaceutical Sciences Series, vol 41. Springer, Cham. https://doi.org/10.1007/978-3-030-35910-2_2

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