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Prevalence, Consequences, Causes and Management of Obesity

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Pathophysiology of Obesity-Induced Health Complications

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 19))

Abstract

Obesity is a growing global health problem and is well-recognized to be a major contributing factor for increased risk of several non-communicable diseases including cardiovascular disease , diabetes and cancer in both the developed and developing world. This development is multi-factorial, but an increasingly sedentary lifestyle coupled with unhealthy dietary practices are key risk factors. Effective interventions for weight management would therefore not only be seen to reduce the epidemic of obesity , but also to lessen the risk for obesity -related morbidities. This article will briefly describe some factors that can cause obesity . Since men and women are different in their fat mass and distribution profile, and that ethnic groups are disproportionately affected by obesity , it is conceivable that disparities also exist in the occurrence of obesity and the consequential development of non-communicable diseases . Although the major adverse health outcomes due to obesity are mentioned, the influence and the role of sex, specifically women’s health , and ethnicity in the increased risk as well as development of obesity -induced health complications will also be discussed.

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References

  1. World Health Organization (2019) https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accesed 11 July 2019

  2. Wagner KH, Brath H (2012) A global view on the development of non communicable diseases. Prev Med 54(Suppl):S38–S41

    Article  PubMed  Google Scholar 

  3. Taherogorabi Z, Khazaei M, Moodi M, Chamani E (2016) From obesity to cancer: a review on proposed mechanisms. Cell Biochem Funct 34:533–545

    Article  CAS  Google Scholar 

  4. Dugani S, Gaziano TA (2016) 25 by 25: achieving global reduction in cardiovascular mortality. Curr Cardiol Rep 18:10

    Article  PubMed  PubMed Central  Google Scholar 

  5. Jagannathan R, Patel SA, Ali MK, Narayan KMV (2019) Global updates on cardiovascular disease mortality trends and attribution of traditional risk factors. Curr Diab Rep 19:44

    Article  PubMed  Google Scholar 

  6. Berry DC, Jiang Y, Graff JM (2016) Emerging roles of adipose progenitor cells in tissue development, homeostasis, expansion and thermogenesis. Trends Endocrinol Metab 27:574–585

    Article  CAS  PubMed  Google Scholar 

  7. Cuthbertson DJ, Steele T, Wilding JP, Halford JC, Harrold JA, Hamer M, Karpe F (2017) What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications? Int J Obes 41:853–865

    Article  CAS  Google Scholar 

  8. Aponte Y, Atasoy D, Sternson SM (2011) AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat Neurosci 14:351–355

    Article  CAS  PubMed  Google Scholar 

  9. Fan W, Boston BA, Kesterson RA et al (1997) Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165–168

    Article  CAS  PubMed  Google Scholar 

  10. Krashes MJ, Koda S, Ye C et al (2011) Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest 121:1424–1428

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Oswal A, Yeo GS (2007) The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics. Obes Rev 8:293–306

    Article  CAS  PubMed  Google Scholar 

  12. Shaw AM, Irani BG, Moore MC et al (2005) Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Peptides 26:1720–1727

    Article  CAS  PubMed  Google Scholar 

  13. Pandit R, Beerens S, Adan RAH (2017) Role of leptin in energy expenditure: the hypothalamic perspective. Am J Physiol Regul Integr Comp Physiol 312:R938–R947

    Article  CAS  PubMed  Google Scholar 

  14. Cui H, López M, Rahmouni K (2017) The cellular and molecular bases of leptin and ghrelin resistance in obesity. Nat Rev Endocrinol 13:338–351

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Belfort-DeAguiar R, Seo D (2018) Food cues and obesity: overpowering hormones and energy balance regulation. Curr Obes Rep 7:122–129

    Article  PubMed  PubMed Central  Google Scholar 

  16. Lutter M, Nestler EJ (2009) Homeostatic and hedonic signals interact in the regulation of food intake. J Nutr 39:629–632

    Article  CAS  Google Scholar 

  17. Lau BK, Cota D, Cristino L, Borgland SL (2017) Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits. Neuropharmacology 124:38–51

    Article  CAS  PubMed  Google Scholar 

  18. Westerterp KR (2017) Control of energy expenditure in humans. Eur J Clin Nutr 71:340–344

    Article  CAS  PubMed  Google Scholar 

  19. St-Onge MP, Gallagher D (2010) Body composition changes with aging: the cause or the result of alterations in metabolic rate and macronutrient oxidation? Nutrition 26:152–155

    Article  CAS  PubMed  Google Scholar 

  20. Keys A, Brozek J, Henschel A et al (1950) The biology of human starvation. University of Minnesota Press, Minneapolis, USA

    Book  Google Scholar 

  21. Teske JA, Billington CJ, Kotz CM (2008) Neuropeptidergic mediators of spontaneous physical activity and non-exercise activity thermogenesis. Neuroendocrinology 87:71–90

    Article  CAS  PubMed  Google Scholar 

  22. van Baak MA (2008) Meal-induced activation of the sympathetic nervous system and its cardiovascular and thermogenic effects in man. Physiol Behav 94:178–186

    Article  PubMed  CAS  Google Scholar 

  23. Tappy L (1996) Thermic effect of food and sympathetic nervous system activity in humans. Reprod Nutr Dev 36:391–397

    Article  CAS  PubMed  Google Scholar 

  24. Reddon H, Patel Y, Turcotte M et al (2018) Revisiting the evolutionary origins of obesity: lazy versus peppy-thrifty genotype hypothesis. Obes Rev 19:1525–1543

    Article  CAS  PubMed  Google Scholar 

  25. Goodarzi MO (2018) Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications. Lancet Diabetes Endocrinol 6:223–236

    Article  CAS  PubMed  Google Scholar 

  26. den Hoed M, Brage S, Zhao JH et al (2013) Heritability of objectively assessed daily physical activity and sedentary behavior. Am J Clin Nutr 98:1317–1325

    Article  CAS  Google Scholar 

  27. Farias MM, Cuevas AM, Rodriguez F (2011) Set-point theory and obesity. Metab Syndr Relat Disord 9:85–89

    Article  PubMed  Google Scholar 

  28. Stöger R (2008) The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? BioEssays 30:156–166

    Article  PubMed  Google Scholar 

  29. Speakman JR (2007) A nonadaptive scenario explaining the genetic predisposition to obesity: the “predation release” hypothesis. Cell Metab 6:5–12

    Article  CAS  PubMed  Google Scholar 

  30. Sellayah D, Cagampang FR, Cox RD (2014) On the evolutionary origins of obesity: a new hypothesis. Endocrinology 155:1573–1588

    Article  PubMed  CAS  Google Scholar 

  31. Belsare PV, Watve MG, Ghaskadbi SS, Bhat DS, Yajnik CS, Jog M (2010) Metabolic syndrome: aggression control mechanisms gone out of control. Med Hypotheses 74:578–589

    Article  CAS  PubMed  Google Scholar 

  32. Brandkvist M, Bjørngaard JH, Ødegård RA et al (2019) Quantifying the impact of genes on body mass index during the obesity epidemic: longitudinal findings from the HUNT Study. BMJ 366:l4067

    Article  PubMed  PubMed Central  Google Scholar 

  33. World Health Organization (2016) Report of the commission on ending childhood obesity. http://apps.who.int.uml.idm.oclc.org/iris/bitstream/10665/204176/1/9789241510066_eng.pdf?ua=1 Version current 1 2016. Accessed 12 July 2019

  34. Garfinkel-Castro A, Kim K, Hamidi S, Ewing R (2017) Obesity and the built environment at different urban scales: examining the literature. Nutr Rev 75:51–61

    Article  PubMed  Google Scholar 

  35. Church TS, Thomas DM, Tudor-Locke C et al (2011) Trends over 5 decades in U.S. occupation-related physical activity and their associations with obesity. PLoS ONE 6:e19657

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Livingstone MB, Pourshahidi LK (2014) Portion size and obesity. Adv Nutr 5:829–834

    Article  PubMed  PubMed Central  Google Scholar 

  37. Nielsen SJ, Popkin BM (2003) Patterns and trends in food portion sizes, 1977–1998. JAMA 289:450–453

    Article  PubMed  Google Scholar 

  38. Zheng M, Rangan A, Meertens B, Wu JHY (2017) Changes in typical portion sizes of commonly consumed discretionary foods among Australian adults from 1995 to 2011–2012. Nutrients 9. pii: E577

    Google Scholar 

  39. Ello-Martin JA, Ledikwe JH, Rolls BJ (2005) The influence of food portion size and energy density on energy intake: implications for weight management. Am J Clin Nutr 82:236S–241S

    Article  CAS  PubMed  Google Scholar 

  40. Wellard L, Havill M, Hughes C et al (2015) Energy-dense fast food products cost less: an observational study of the energy density and energy cost of Australian fast foods. Aust N Z J Public Health 39:544–545

    Article  PubMed  Google Scholar 

  41. Moubarac JC, Parra DC, Cannon G, Monteiro CA (2014) Food classification systems based on food processing: significance and implications for policies and actions: a systematic literature review and assessment. Curr Obes Rep 3:256–272

    Article  PubMed  Google Scholar 

  42. Marrón-Ponce JA, Tolentino-Mayo L, Hernández-F M, Batis C (2018) Trends in ultra-processed food purchases from 1984 to 2016 in Mexican households. Nutrients 11:2018

    Article  PubMed Central  Google Scholar 

  43. Solberg SL, Terragni L, Granheim SI (2016) Ultra-processed food purchases in Norway: a quantitative study on a representative sample of food retailers. Ultra-processed food purchases in Norway: a quantitative study on a representative sample of food retailers. Public Health Nutr 19:1990–2001

    Article  PubMed  Google Scholar 

  44. Martínez Steele E, Baraldi LG, Louzada ML et al (2016) Ultra-processed foods and added sugars in the US diet: evidence from a nationally representative cross-sectional study. BMJ Open 6:e009892

    Article  PubMed  PubMed Central  Google Scholar 

  45. Adams J, White M (2015) Characterization of UK diets according to degree of food processing and associations with socio-demographics and obesity: cross-sectional analysis of UK National Diet and Nutrition Survey (2008–12). Int J Behav Nutr Phys Act 12:160

    Article  PubMed  PubMed Central  Google Scholar 

  46. Julia C, Martinez L, Allès B et al (2018) Contribution of ultra-processed foods in the diet of adults from the French NutriNet-Santé study. Public Health Nutr 21:27–37

    Article  PubMed  Google Scholar 

  47. Louzada ML, Baraldi LG, Steele EM et al (2015) Consumption of ultra-processed foods and obesity in Brazilian adolescents and adults. Prev Med 81:9–15

    Article  PubMed  Google Scholar 

  48. Mendonça RD, Pimenta AM, Gea A, de la Fuente-Arrillaga C et al (2016) Ultra-processed food consumption and risk of overweight and obesity: the University of Navarra Follow-Up (SUN) cohort study. Am J Clin Nutr 104:1433–1440

    Article  PubMed  CAS  Google Scholar 

  49. Canella DS, Levy RB, Martins AP et al (2014) Ultra-processed food products and obesity in Brazilian households (2008–2009). PLoS ONE 9:e92752

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  50. Hall KD, Ayuketah A, Brychta R et al (2019) Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake. Cell Metab 30:67–77.e3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Prentice AM (2006) The emerging epidemic of obesity in developing countries. J Epidemiol 35:93–99

    Google Scholar 

  52. Lee MJ, Fried SK (2017) Sex-dependent depot differences in adipose tissue development and function; role of sex steroids. J Obes Metab Syndr 26:172–180

    Article  PubMed  PubMed Central  Google Scholar 

  53. Leeners B, Geary N, Tobler PN, Asarian L (2017) Ovarian hormones and obesity. Hum Reprod Update 23:300–321

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Bowen DJ, Tomoyasu N, Cauce AM (1991) The triple threat: a discussion of gender, class, and race differences in weight. Women Health 17:123–143

    Article  CAS  PubMed  Google Scholar 

  55. Bandera EV, Maskarinec G, Romieu I, John EM (2015) Racial and ethnic disparities in the impact of obesity on breast cancer risk and survival: a global perspective. Adv Nutr 6:803–819

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Poston L, Caleyachetty R, Cnattingius S et al (2016) Preconceptional and maternal obesity: epidemiology and health consequences. Lancet Diabetes Endocrinol 4:1025–1036

    Article  PubMed  Google Scholar 

  57. Kelly-Weeder S, Cox CL (2006) The impact of lifestyle risk factors on female infertility. Women Health 44:1–23

    Article  PubMed  Google Scholar 

  58. Chandrasekaran S, Neal-Perry G (2017) Long-term consequences of obesity on female fertility and the health of offspring. Curr Opin Obstet Gynecol 29:180–187

    Article  PubMed  PubMed Central  Google Scholar 

  59. Marchi J, Berg M, Dencker A et al (2015) Risks associated with obesity in pregnancy, for the mother and baby: a systematic review of reviews. Obes Res 16:621–638

    Article  CAS  Google Scholar 

  60. Luke B (2017) Adverse effects of female obesity and interaction with race on reproductive potential. Fertil Steril 107:868–877

    Article  PubMed  Google Scholar 

  61. Chu DT, Minh Nguyet NT, Nga VT et al (2019) An update on obesity: mental consequences and psychological interventions. Diabetes Metab Syndr 13:155–160

    Article  PubMed  Google Scholar 

  62. Faria-Schützer DB, Surita FG, Nascimento SL et al (2017) Psychological issues facing obese pregnant women: a systematic review. J Matern Fetal Neonatal Med 30:88–95

    Article  PubMed  Google Scholar 

  63. Meier RK (2018) Polycystic ovary syndrome. Nurs Clin North Am 53:407–420

    Article  PubMed  Google Scholar 

  64. McTiernan A (2000) Associations between energy balance and body mass index and risk of breast carcinoma in women from diverse racial and ethnic backgrounds in the U.S. Cancer 88:1248–1255

    Article  CAS  PubMed  Google Scholar 

  65. Dietze EC, Chavez TA, Seewaldt VL (2018) Obesity and triple-negative breast cancer: disparities, controversies, and biology. Am J Pathol 188:280–290

    Article  PubMed  PubMed Central  Google Scholar 

  66. Tworoger SS, Huang T (2016) Obesity and ovarian cancer. 208:155–176

    CAS  Google Scholar 

  67. Fu Q (2019) Sex differences in sympathetic activity in obesity and its related hypertension. Ann NY Acad Sci 1454:31–41

    Article  PubMed  Google Scholar 

  68. Kapoor E, Collazo-Clavell ML, Faubion SS (2017) Weight gain in women in midlife: a concise review of the pathophysiology and strategies for management. Mayo Clin Proc 92:1552–1558

    Article  PubMed  Google Scholar 

  69. Abate N, Chandalia M (2003) The impact of ethnicity on type 2 diabetes. J Diabetes Complic 17:39–58

    Article  Google Scholar 

  70. Nesbitt SD, Ashaye MO, Stettler N et al (2004) Overweight as a risk factor in children: a focus on ethnicity. Ethn Dis 14:94–110

    PubMed  Google Scholar 

  71. Renzaho AM, Halliday JA, Nowson C (2011) Vitamin D, obesity, and obesity-related chronic disease among ethnic minorities: a systematic review. Nutrition 27:868–879

    Article  CAS  PubMed  Google Scholar 

  72. Story M, Stevens J, Himes J et al (2003) Obesity in American-Indian children: prevelance, consequences, and prevention. Prev Med 37:S3–S12

    Article  PubMed  Google Scholar 

  73. Szanto KB, Li J, Cordero P, Oben JA (2019) Ethnic differences and heterogeneity in genetic and metabolic makeup contributing to nonalcoholic fatty liver disease. Diabetes Metab Syndr Obes 12:357–367

    Article  PubMed  PubMed Central  Google Scholar 

  74. Yracheta JM, Alfonso J, Lanaspa MA et al (2015) Postgrad Med 127:503–510

    Article  PubMed  Google Scholar 

  75. Misra A, Khurana L (2011) Obesity-related non-communicable diseases: South Asians vs white Caucasians. Int J Obes 35:167–187

    Article  CAS  Google Scholar 

  76. Bhupathiraju SN, Hu FB (2016) Epidemiology of obesity and diabetes and their cardiovascular complications. Circ Res 118:1723–1735

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Desai N, Lora CM, Lash JP, Ricardo AC (2019) CKD and ESRD in US Hispanics. Am J Kidney Dis 73:102–111

    Article  PubMed  Google Scholar 

  78. Kumanyika SK (1997) The impact of obesity on hypertension management in African Americans. J Health Care Poor Underserved 8:352–364

    Article  CAS  PubMed  Google Scholar 

  79. Kumanyika S (1987) Obesity in black women. Epidemiol Rev 9:31–50

    Article  CAS  PubMed  Google Scholar 

  80. Obesity Canada (2019) https://obesitycanada.ca/managing-obesity/. Accessed 10 July 2019

  81. Semlitsch T, Stigler FL, Jeitler K et al (2019) Management of overweight and obesity in primary care-A systematic overview of international evidence-based guidelines. Obes Rev 20:1218–1230

    Article  PubMed  PubMed Central  Google Scholar 

  82. Sweeting AN, Caterson ID (2017) Approaches to obesity management. Intern Med J 47:734–739

    Article  PubMed  Google Scholar 

  83. Burgess E, Hassmén P, Pumpa KL (2017) Determinants of adherence to lifestyle intervention in adults with obesity: a systematic review. Clin Obes 7:123–135

    Article  CAS  PubMed  Google Scholar 

  84. Wing RR, Phelan S (2005) Long-term weight loss maintenance. Am J Clin Nutr 82:222S–225S

    Article  CAS  PubMed  Google Scholar 

  85. Thomas JG, Bond DS, Phelan S et al (2014) Weight-loss maintenance for 10 years in the National Weight Control Registry. Am J Prev Med 46:17–23

    Article  PubMed  Google Scholar 

  86. Parretti HM, Jebb SA, Johns DJ et al (2016) Clinical effectiveness of very-low-energy diets in the management of weight loss: a systematic review and meta-analysis of randomized controlled trials. Obes Rev 17:225–234

    Article  CAS  PubMed  Google Scholar 

  87. Fothergill E, Guo J, Howard L et al (2016) Persistent metabolic adaptation 6 years after “The Biggest Loser” competition. Obesity (Silver Spring). 24:1612–1619

    Article  PubMed Central  Google Scholar 

  88. Hansen TT, Hjorth MF, Sandby K et al (2019) Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet. Br J Nutr 27:1–12

    Google Scholar 

  89. Connolly HM, Crary JL, McGoon MD et al (1997) Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 337:581–588

    Article  CAS  PubMed  Google Scholar 

  90. James WP, Caterson ID, Coutinho W et al (2010) Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med 363:905–917

    Article  CAS  PubMed  Google Scholar 

  91. Daneschvar HL, Aronson MD, Smetana GW (2016) FDA-approved anti-obesity drugs in the United States. Am J Med 129(879):e1–e6

    Google Scholar 

  92. Sweeting AN, Hocking SL, Markovic TP (2015) Pharmacotherapy for the treatment of obesity. Mol Cell Endocrinol 418:173–183

    Article  CAS  PubMed  Google Scholar 

  93. Krentz AJ, Fujioka K, Hompesch M (2016) Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles. Diabetes Obes Metab 18:558–570

    Article  CAS  PubMed  Google Scholar 

  94. International Federation for the Surgery of Obesity and Metabolic Disorders (2019) Are you a candidate. https://www.ifso.com/are-you-a-candidate/. Accessed 11 July 2019

  95. Madsbad S, Dirksen C, Holst JJ (2014) Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery. Lancet Diabetes Endocrinol 2:152–164

    Article  CAS  PubMed  Google Scholar 

  96. Tremaroli V, Karlsson F, Werling M et al (2015) Gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation. Cell Metab 22:228–238

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Ahmad A, Kornrich DB, Krasner H et al (2019) Prevalence of dumping syndrome after laparoscopic sleeve gastrectomy and comparison with Laparoscopic Roux-en-Y gastric bypass. Obes Surg 29:1506–1513

    Article  PubMed  Google Scholar 

  98. Stroh C, Manger T, Benedix F (2017) Metabolic surgery and nutritional deficiencies. Minerva Chir 72:432–441

    PubMed  Google Scholar 

  99. Gregory NS (2017) The effects of bariatric surgery on bone metabolism. Endocrinol Metab Clin North Am 46:105–116

    Article  PubMed  Google Scholar 

  100. Angeles PC, Robertsen I, Seeberg LT et al (2019) The influence of bariatric surgery on oral drug bioavailability in patients with obesity: a systematic review. Obes Rev 20:1299–1311

    Article  PubMed  PubMed Central  Google Scholar 

  101. Lamarca F, Melendez-Araújo MS, Porto de Toledo I et al (2019) Relative energy expenditure decreases during the first year after bariatric surgery: a systematic review and meta-analysis. Obes Surg 29:2648–2659

    Article  PubMed  Google Scholar 

  102. Chang SH, Stoll CR, Song J et al (2014) The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012. JAMA Surg 149:275–287

    Article  PubMed  PubMed Central  Google Scholar 

  103. Gloy VL, Briel M, Bhatt DL et al (2013) Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ 347:f5934

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

Infrastructural support was provided by the St. Boniface Hospital Research Foundation and the University of Winnipeg.

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Tappia, P.S., Defries, D. (2020). Prevalence, Consequences, Causes and Management of Obesity. In: Tappia, P., Ramjiawan, B., Dhalla, N. (eds) Pathophysiology of Obesity-Induced Health Complications. Advances in Biochemistry in Health and Disease, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-030-35358-2_1

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