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PET and PET/MRI Methods

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Neuroimaging in Schizophrenia

Abstract

The goal of this chapter is to provide the reader with a basic understanding of Positron Emission Tomography (PET) imaging and simultaneous PET and magnetic resonance (or PET/MR) imaging. These topics are presented with particular emphasis on PET as a molecular imaging tool and MRI as a structural and functional imaging tool. The chapter begins with an introduction to the underlying PET physics and a brief review of how data are acquired and reconstructed into 3D images. This includes common corrections that are applied to minimize image artifacts and improve accuracy, as well as a brief discussion of key advantages and limitations of PET and MRI and the benefits of combined PET/MR imaging. The strengths of PET as a molecular imaging technology are then presented in the context of in vivo imaging of protein targets that are relevant to schizophrenia and other neuropsychiatric disorders. This includes a basic review of PET pharmacokinetic methods used to evaluate radioligand-protein binding interactions and simpler and more feasible methods used for routine PET assessments. The final section presents a discussion of future directions and recent advances in PET/MR imaging applications.

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Authors and Affiliations

  1. Department of Radiology, Massachusetts General Hospital, Boston, MA, USA

    Cristina Lois, Hasan Sari, Amanda B. Sidwell & Julie C. Price

  2. Harvard Medical School, Boston, MA, USA

    Cristina Lois, Hasan Sari & Julie C. Price

  3. Gordon Center for Medical Imaging, Boston, MA, USA

    Cristina Lois

  4. PET Pharmacokinetic Modeling, Athinoula A. Martinos Center, Charlestown, MA, USA

    Hasan Sari, Amanda B. Sidwell & Julie C. Price

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  1. Cristina Lois
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  2. Hasan Sari
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  3. Amanda B. Sidwell
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  4. Julie C. Price
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Correspondence to Julie C. Price .

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Editors and Affiliations

  1. Department of Psychiatry and Radiology, Brigham and Women’s Hospital, Boston, MA, USA

    Marek Kubicki

  2. Department of Psychiatry and Radiology, Brigham and Women’s Hospital, Boston, MA, USA

    Martha E. Shenton

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Lois, C., Sari, H., Sidwell, A.B., Price, J.C. (2020). PET and PET/MRI Methods. In: Kubicki, M., Shenton, M. (eds) Neuroimaging in Schizophrenia . Springer, Cham. https://doi.org/10.1007/978-3-030-35206-6_7

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