Abstract
Progression in genetic engineering has led to proliferation of a wide variety of proteins, peptides, genes, and other macromolecules. Despite their efficacy and selectivity in physiological functions, administration of most of the bioactives is a hard task to achieve. To overcome these limitations, enormous efforts are being made to formulate these bioactives into patient-friendly system using the approaches of novel drug delivery systems mainly based on liposomes, nanocapsules, nanoemulsions, niosomes, hydrogels, nanoparticles, and bioadhesive particles. Among these nano size carriers attract huge intention because at this size surface area enhances exponentially which surprisingly changes the many aspects compared to conventional particles. The key objectives in developing nanocarriers are to manage particle diameter, surface characteristics, as well as effective delivery without degradation to fulfill the specific objectives. Hence, characterizations of these nanocarriers are very critical to control their desired behavior in vitro as well as in vivo. Later on, these carriers were conjugated by specific ligand in order to deliver protein therapeutics into the target organs in active form. Infact, one of the major issues of the nanocarrier-mediated delivery is that the stability issues of bioactives inside the matrix insist selection of appropriate carriers for efficient delivery. Also, this chapter describes challenges and restrictions for the delivery of bioactives, and selection of nanocarriers such as nanoparticles and liposomes to achieve the desired response specifically at the site of action and other carriers can enhance the pharmacokinetic behavior of bioactives, therefore minimizing toxic effects and make the most of the therapeutic benefits.
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References
Ahmad J, Singhal M, Amin S, Rizwanullah M, Akhter S, Kamal MA et al (2017) Bile salt stabilized vesicles (Bilosomes): a novel nano-pharmaceutical design for oral delivery of proteins and peptides. Curr Pharm Des 23(11):1575–1588
Almeida AJ, Runge S, Muller RH (1997) Peptide-loaded solid lipid nanoparticles (SLN): influence of production parameters. Int J Pharm Sci 149(2):255–265
Anderson KE, Stevenson BR, Rogers JA (1999) Folic acid-PEO-labeled liposomes to improve gastrointestinal absorption of encapsulated agents. J Control Release 60:189–198
Barbari GR, Dorkoosh FA, Amini M, Sharifzadeh M, Atyabi F, Balalaie S et al (2017) A novel nanoemulsion-based method to produce ultrasmall, water-dispersible nanoparticles from chitosan, surface modified with cell-penetrating peptide for oral delivery of proteins and peptides. Int J Nanomedicine 12:3471–3483
Bi R, Shao W, Wang Q, Zhang N (2008) Spray-freeze-dried dry powder inhalation of insulin loaded liposomes for enhanced pulmonary delivery. J Drug Target 16:639–648
Bisker G, Yeheskely-Hayon D, Minai L, Yelin D (2012) Controlled release of Rituximab from gold nanoparticles for phototherapy of malignant cells. J Control Release 162:303–309
Biswal S, Murthy PN, Sahu J, Sahoo P, Amir F (2008) Vesicles of non-ionic surfactants niosomes and drug delivery potential. Int J Pharm Sci Nanotechnol 1:1–10
Caliceti P, Brossa A, Salmaso S, Bersani S, Elvassore N, Bertucco A (2006) Preparation of protein loaded solid lipid nano-particles by compressed fluid process. Proc Int Symp Control Release Bioact Mater 33:383
Carsten R, Ulrike S, Aurora O et al (2004) Application of novel solid lipid nanoparticle (SLN)-gene vector formulations based on a dimeric HIV-1 TAT-peptide in vitro and in vivo. Pharm Res 21:1662–1669
Cavalli R, Bocca C, Miglietta A, Caputo O, Gasco M (1999) Albumin adsorption on stealth and non-stealth solid lipid nanoparticles. STP Pharm Sci 9(2):183–189
Chalasani KB, Russel-Jones GJ, Jain AK, Jain SK, Diwan PV (2007) Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J Control Release 122:141–150
Chatin B, Mevel M, Devalliere J, Dallet L, Haudebourg T, Peuziat P et al (2015) Liposome-based formulation for intracellular delivery of functional proteins. Mol Ther Nucleic Acid 4:e244
Cho SK, Emoto K, Su LJ, Yang X, Flaig TW, Park W (2014) Functionalized gold nanorods for thermal ablation treatment of bladder cancer. J Biomed Nanotechnol 10:1267–1276
Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD (2005) Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 1:325–327
Damge C, Maincent P, Ubrich N (2007) Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release 117:163–170
Deng Z, Zhen Z, Hu X, Wu S, Xu Z, Chu PK (2011) Hollow chitosan-silica nanospheres as pH-sensitive targeted delivery carriers in breast cancer therapy. Biomaterials 32:4976–4986
Desai MP, Labhasetwar V, Amidon GL, Levy RJ (1996) Gastrointestinal uptake of biodegradable microparticles effect of particle size. Pharm Res 13:1838–1845
Duan J, Zhang Y, Chen W, Shen C, Liao M, Pan Y et al (2009) Cationic polybutyl cyanoacrylate nanoparticles for DNA delivery. J Biomed Biotechnol 2009:149254
Duncan MR, Lee JM, Warchol MP (1995) Influence of surfactants upon protein/peptide adsorption to glass and polypropylene. Int J Pharm Sci 120(2):179–188
Fan T, Chen C, Guo H, Xu J, Zhang J, Zhu X et al (2014) Design and evaluation of solid lipid nanoparticles modified with peptide ligand for oral delivery of protein drugs. Eur J Pharm Biopharm 88(2):518–528
Fang JY, Hong CT, Chiu WT, Wang YY (2001) Effect of liposomes and niosomes on skin permeation of enoxacin. Int J Pharm 219:61–72
Garcia-Fuentes M, Torres D, Alonso M (2003) Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules. Colloids Sur B Interfaces 27(2):159–168
Garcia-Fuentes M, Prego C, Torres D, Alonso MJ (2005a) A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery. Eur J Pharm Sci 25(1):133–143
Garcia-Fuentes M, Torres D, Alonso MJ (2005b) New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin. Int J Pharm Sci 296(1–2):122–132
Ghosh XP, Yang R, Arvizo ZJ, Zhu SS, Agasti Z, Rotello VJ (2010) Intracellular delivery of a membrane-impermeable enzyme in active form using functionalized gold nanoparticles. Am Chem Soc 132:2642–2645
Goppert TM, Muller RH (2005) Protein adsorption patterns on poloxamer- and poloxamine-stabilized solid lipid nanoparticles (SLN). Eur J Pharm Biopharm 3:361–372
Gualbert J, Shahgaldian P, Coleman AW (2003) Interactions of amphiphilic calix[4]arene-based Solid Lipid Nanoparticles with bovine serum albumin. Int J Pharm Sci 257(1–2):69–73
Hadjipanayis CG, Machaidze R, Kaluzova M, Wang L, Schuette AJ, Chen H et al (2010) EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging- guided convection-enhanced delivery and targeted therapy of glioblastoma. Cancer Res 70(15):6303–6312
Hou D, Xie C, Huang K, Zhu C (2003) The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials 24(10):1781–1785
Hu FQ, Hong Y, Yuan H (2004) Preparation and characterization of solid lipid nanoparticles containing peptide. Int J Pharm Sci 273(1–2):29–35
Ishida T, Harashim H, Kiwada H (2002) Liposome clearance. Biosci Rep 22:197–224
Jain AK, Khar RK, Ahmed FJ, Diwan PV (2008) Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier. Eur J Pharm Biopharm 69(2):226–435
Jong WHD, Borm PJA (2008) Drug delivery and nanoparticle applications and hazards. Int J Nanomedicine 3(2):133–149
Joshi MD, Muller RH (2009) Lipid nanoparticles for parenteral delivery of actives. Eur J Pharm Biopharm 71(2):161–172
Kedar E, Braun E, Rutkowski Y, Emanuel N, Barenholz Y (1994) Delivery of cytokines by liposomes II. Interleukin-2 encapsulated in long-circulating sterically stabilized liposomes: Immunomodulatory and anti-tumor activity in mice. J Immunother Emphasis Tumor Immunol 16:115–124
Khaksa G, D’Souza R, Lewis S, Udupa N (2000) Pharmacokinetic study of niosome encapsulated insulin. Indian J Exp Biol 38:901–905
Lai CY, Trewyn BG, Jeftinija DM (2003) A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. J Am Chem Soc 125:4451–4459
Lee H, Lee MY, Bhang SH (2014) Hyaluronate-gold nanoparticle/Tocilizumab complex for the treatment of rheumatoid arthritis. ACS Nano 8:4790–4798
Lei C, Liu P, Chen B (2010) Local release of highly loaded antibodies from functionalized nanoporous support for cancer immunotherapy. J Am Chem Soc 132:6906–6907
Li S, Zhao B, Wang F, Wang M, Xie S, Wang S et al (2010) Yak interferon-alpha loaded solid lipid nanoparticles for controlled release. Res Vet Sci 88:48–153
Li Y, Chen X, Liu H, Mou X, Ren Z, Ahmad Z et al (2017) Silica nanospheres entrapped with ultra-small luminescent crystals for protein delivery. Chem Eng J 330:166–174
Liguori L, Marques B, Villegas-Mendez A, Rothe R, Lenormand JL (2008) Liposomes mediated delivery of pro-apoptotic therapeutic membrane proteins. J Control Release 126:217–227
Liu W, He Z, Liang J, Zhu Y, Xu H, Yang X (2008) Preparation and characterization of novel fluorescent nanocomposite particles: CdSe/ZnS core-shell quantum dots loaded solid lipid nanoparticles. J Biomed Mater Res 84(4):1018–1025
Lu J, Liong M, Sherman S, Xia T, Kovochich M, Nel AE et al (2007) Mesoporous silica nanoparticles for cancer therapy: energy-dependent cellular uptake and delivery of paclitaxel to cancer cells. Nanobiotechnology 3:89–95
Macura SL, Steinbacher JL, MacPherson MB (2013) Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts. BMC Cancer 13:400
Mahony D, Cavallaro AS, Stahr F, Mahony TJ, Qiao SZ, Mitter N (2013) Mesoporous silica nanoparticles act as a self-adjuvant for ovalbumin model antigen in mice. Small 9(18):3138–3146
Malhotra M, Jain NK (1994) Niosomes as drug carriers. Indian Drugs 31:81–86
Malmsten M, Zauscher S (2013) Colloids and surfaces in biology. Curr Opin Colloid Sci 18:468
Manosroi A, Lohcharoenkal W, Gotz F, Werner RG, Manosroi W, Manosroi J (2011) Cellular uptake enhancement of Tat-GFP fusion protein loaded in elastic niosomes. J Biomed Nanotechnol 7:366–376
Marcato PD, Duran N (2008) New aspects of nanopharmaceutical delivery systems. J Nanosci Nanotechnol 8(5):2216–2229
Martins S, Sarmento B, Ferreira DC, Souto EB (2007) Lipid-based colloidal carriers for peptide and protein delivery--liposomes versus lipid nanoparticles. Int J Nanomedicine 2(4):595–607
Mehnert W, Mader K (2001) Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev 47(2–3):165–196
Morel S, Rosa Gasco M, Cavalli R (1994) Incorporation in lipospheres of [d-Trp-6]LHRH. Int J Pharm Sci 105(2):R1–R3
Morel S, Ugazio E, Cavalli R, Gasco MR (1996) Thymopentin in solid lipid nanoparticles, Int J Pharm 132(1–2):259–261
Muller R, Mehnert W, Lucks J-S, Schwarz C, Zur Mühlen A, Meyhers H et al (1995) Solid lipid nanoparticles (SLN): an alternative colloidal carrier system for controlled drug delivery. Eur J Pharm Biopharm 41(1):62–69
Muller RH, Mader K, Gohla S (2000) Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. Eur J Pharm Biopharm 50(1):161–177
Muller RH, Runge S, Ravelli V, Mehnert W, Thunemann AF, Souto EB (2006) Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals. Int J Pharm Sci 317(1):82–89
Niven RW, Lott FD, Ip AY, Cribbs JM (1994) Pulmonary delivery of powders and solutions containing recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the rabbit. Pharm Res 11:1101–1109
Olbrich C, Runge SA, Mehnert W, Thunemann AF, Muller RH (2000) Entrapment efficiency and biodegradation of cyclosporine loaded solid lipid nanoparticles (SLN) for peroral administration. In: Proc. 3rd world meeting APV/APGI, Berlin, pp 425–426
Patel RP, Patel H, Baria AH (2009) Formulation and evaluation of liposomes of ketokonazole. Int J Drug Deliv Technol 1(1):16–23
Patel S, Bhirde AA, Rusling JF, Chen X, Gutkind JS, Patel V (2011) Nano delivers big: designing molecular missiles for cancer therapeutics. Pharmaceutics 3(1):34–52
Prasetyanto EA, Bertucci A, Septiadi D, Corradini R, Castro-Hartmann P, De Cola L (2016) Breakable hybrid organosilica nanocapsules for protein delivery. Angew Chem Int Ed Engl 55(10):3323–3327
Radin S, Falaize S, Lee MH, Ducheyne P (2002) In vitro bioactivity and degradation behavior of silica xerogels intended as controlled release materials. Biomaterials 23:3113–3122
Radtke M, Muller RH (2001a) Novel concept of topical cyclosporine delivery with supersaturated SLN creams. Proc Int Symp Control Release Bioact Mater 28:470–471
Radtke M, Muller RH (2001b) Stability study of creams containing cyclosporine SLN. Proc Int Symp Control Release Bioact Mater 28:472–473
Ramachandran R, Paul W, Sharma CP (2008) Synthesis and characterization of. J Biomed Mater Res B 18:699–703
Rentel CO, Bouwstra JA, Naisbett B, Junginger HE (1999) Niosomes as a novel peroral vaccine delivery system. Int J Pharm 186:161–167
Rezler EM, Khan DR, Lauer-Fields J, Cudic M, Baronas-Lowell D, Fields GB (2007) Targeted drug delivery utilizing protein-like molecular architecture. J Am Chem Soc 129:4961–4972
Rytting E, Nguyen J, Wang X, Kissel T (2008) Biodegradable polymeric nanocarriers for pulmonary drug delivery. Expert Opin Drug Deliv 5:629–639
Shao X, Zhang J, Rajian R (2011) 125I-labeled gold nanorods for targeted imaging of inflammation. ACS Nano 5:8967–8973
Shen J, Li K, Cheng L, Liu Z, Lee ST, Liu J (2014) Specific detection and simultaneously localized photothermal treatment of cancer cells using layer-by-layer assembled multifunctional nanoparticles. ACS Appl Mater Interfaces 6:6443–6452
Slowing I, Trewyn BG, Lin VSY (2006) Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells. J Am Chem Soc 128:14792–14793
Solaro R (2008) Targeted delivery of proteins by nanosized carriers. J Polym Sci 46:1–11
Solaro R, Chiellini F (2006) Nanoparticles for the targeted delivery of peptides and proteins. In: Ravi Kumar MNV (ed) Handbook of particulate drug delivery, vol 2. American Scientific Publisher, New York, pp 193–222
Song YK, Liu D, Maruyama K, Takizawa T (1996) Antibody mediated lung targeting of long circulating emulsions. J Pharm Sci Tech 50:372–377
Song M, Zhang Y, Chen K, Wang H, Gong R (2017) Carboxymethyl-β-cyclodextrin grafted chitosan nanoparticles as oral delivery carrier of protein drugs. React Funct Polym 117:10–15
Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE (2001) Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 70:1–20
Sundarraj S, Thangam R, Sujitha MV, Vimala K, Kannan S (2014) Ligand-conjugated mesoporous silica nanorattles based on enzyme targeted prodrug delivery system for effective lung cancer therapy. Toxicol Appl Pharmacol 275:232–243
Tan W, Wang K, He X, Zhao XJ, Drake T, Wang L et al (2004) Bionanotechnology based on silica nanoparticles. Med Res Rev 24:621–638
Tang H, Kobayashi H, Niidome Y, Mori T, Katayama Y, Niidome T (2013) CW/pulsed NIR irradiation of gold nanorods: effect on transdermal protein delivery mediated by photothermal ablation. J Control Release 171(2):178–183
Tkachenko AG, Xie H, Coleman D, Glomm W, Ryan J, Anderson MF et al (2003) Multifunctional gold nanoparticle-peptide complexes for nuclear targeting. J Am Chem Soc 125:4700–4701
Ugazio E, Cavalli R, Gasco MR (2002) Incorporation of cyclosporin A in solid lipid nanoparticles (SLN). Int J Pharm Sci 241:341–344
Vallet-Regi M, Balas F, Arcos D (2007) Mesoporous materials for drug delivery. Angew Chem 46:7548–7558
Vauthier C, Bouchemal K (2009) Methods for the preparation and manufacture of polymeric nanoparticles. Pharm Res 26:1025–1058
Videira M, Azevedo AF, Almeida AJ (1998) Entrapment of a high molecular weight protein into solid lipid nanoparticles. APV/APGI:629–630
Videira M, Florin do H, Almeida AJ (2002) Preparation of solid lipid nanoparticles (SLN): a potential protein delivery system. V Spanish–Portuguese Con Control Drug Del:69–70
Vila A, Sanchez A, Tobio M, Calvo P, Alonso MJ (2002) Design of biodegradable particles for protein delivery. Bouchemal J Control Release 78:15–24
Vila A, Sanchez A, Evora CI, Soriano I, McCallion O, Alonso MJ (2005) PLA-PEG particlesas nasal protein carriers: the influence of the particle size. Int J Pharm 292:43–52
Vyas SP, Khar RK (2002) Targeted and controlled drug delivery, 1st edn. CBS Publishers and Distributors, New Delhi, pp 332–334
Wissing SA, Kayser O, Muller RH (2004) Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 56(9):1257–1272
Xing X, He X, Peng J, Wang K, Tan W (2005) Uptake of silica coated nanoparticles by HeLa cells. J Nanosci Nanotechnol 5:1688–1693
Yi J, Lam TI, Yokoyama W, Cheng LW, Zhong F (2014) Cellular uptake of beta-carotene from protein stabilized solid lipid nanoparticles prepared by homogenization-evaporation method. J Agri Food Chem 62(5):1096–1104
Yousefi A, Esmaeili F, Rahimian S, Atyabi F, Dinarvand R (2009) Preparation and in vitro evaluation of a pegylated nano-liposomal formulation containing docetaxel. Sci Pharm 77:453–464
Yu M, Wu J, Shi J, Farokhzad OC (2016) Nanotechnology for protein delivery: Overview and perspectives. J Control Release 240:24–37
Zhang Q, Yie G, Li Y, Yang Q, Na gai T (2000) Studies on the cyclosporin A loaded stearic acid nanoparticles. Int J Pharm Sci 200:153–159
Zhang N, Ping Q, Huang G, Xu W, Cheng Y, Han X (2006) Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int J Pharm 327(1–2):153–159
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Jain, A.K., Gupta, U. (2020). Nanomaterials Used for Delivery of Bioactives. In: Bhushan, I., Singh, V., Tripathi, D. (eds) Nanomaterials and Environmental Biotechnology. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-34544-0_19
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