Abstract
Bacterial infection and lack of osteoinductive ability are the major concerns of titanium-based bone implants. This chapter describes the construction of bio-functionalized ZnO coatings with both self-antibacterial and osteoinductive properties on titanium implants. To obtain ZnO-modified coatings with strong binding forces with substrates, two preparation methods are presented including atomic layer deposition and laser cladding techniques. Next, the antibacterial and osteoinductive properties of ZnO-based coatings are described including Ag/ZnO/hydroxyapatite-Ti, Ti-ZnO/polydopamine/arginine-glycine-aspartic acid-cysteine and poly(lactic-co-glycolic acid)/Ag/ZnO-Ti. We summarize the balancing strategies of reducing cytotoxicity of ZnO to bone cells and enhancing its toxicity towards bacteria.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Li J, Tan L, Liu X et al (2017) Balancing bacteria–osteoblast competition through selective physical puncture and biofunctionalization of ZnO/polydopamine/arginine-glycine-aspartic acid-cysteine nanorods. ACS Nano 11:11250–11263
Jung Kyu P, Yong-Jin K, Junseok Y et al (2010) The topographic effect of zinc oxide nanoflowers on osteoblast growth and osseointegration. Adv Mater 22:4857–4861
Zhu Y, Liu X, Yeung KWK, Chu PK, Wu S (2016) Biofunctionalization of carbon nanotubes/chitosan hybrids on Ti implants by atom layer deposited ZnO nanostructures. Appl Surf Sci 400:14–23
Zhang Y, Liu X, Li Z et al (2017) Nano Ag/ZnO incorporated hydroxyapatite composite coatings: highly effective infection prevention and excellent osteointegration. ACS Appl Mater Interfaces 10:1266–1277
Suntola T, Antson J (1977) Method for producing compound thin films: U.S. Patent 4,058,430 [P]. 11–15
George SM (2010) Atomic layer deposition: an overview. Chem Rev 110:111–131
Park JW, Kim Y, Park C et al (2009) Enhanced osteoblast response to an equal channel angular pressing-processed pure titanium substrate with microrough surface topography. Acta Biomater 5:3272–3280
Comesaña R, Quintero F, Lusquiños F et al (2010) Laser cladding of bioactive glass coatings. Acta Biomater 6:953–961
Xiang Y, Li J, Liu X et al (2017) Construction of poly(lactic-co-glycolic acid)/ZnO nanorods/Ag nanoparticles hybrid coating on Ti implants for enhanced antibacterial activity and biocompatibility. Mater Sci Eng C 79:629–637
Wang T, Liu X, Zhu Y et al (2017) Metal ion coordination polymer-capped pH-triggered drug release system on titania nanotubes for enhancing self-antibacterial capability of Ti implants. ACS Biomater Sci Eng 3:816–825
Li Y, Liu X, Tan L et al (2017) Construction of N-halamine labeled silica/zinc oxide hybrid nanoparticles for enhancing antibacterial ability of Ti implants. Mater Sci Eng C 76:50–58
Zhang K, Zhu Y, Liu X et al (2017) Sr/ZnO doped titania nanotube array: an effective surface system with excellent osteoinductivity and self-antibacterial activity. Mater Des 130:403–412
Tan L, Li J, Liu X et al (2018) Rapid biofilm eradication on bone implants using red phosphorus and near-infrared light. Adv Mater 30:1801808
Li J, Liu X, Tan L et al (2019) Light-activated rapid disinfection by accelerated charge transfer in red phosphorus/ZnO heterointerface. Small Methods 3:1900048
Acknowledgements
This work was partially supported by the National Natural Science Foundation of China, Nos. 51801056, 51671081, 51871162, and 51422102, and the National Key Research and Development Program of China No. 2016YFC1100600 (subproject 2016YFC1100604), and the Natural Science Fund of Hubei Province, 2018CFA064. The authors also gratefully acknowledge the helpful comments and suggestions of the reviewers, which have improved the presentation.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Tan, L., Liu, X., Wu, S. (2020). Construction of Bio-functionalized ZnO Coatings on Titanium Implants with Both Self-Antibacterial and Osteoinductive Properties. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34471-9_7
Download citation
DOI: https://doi.org/10.1007/978-3-030-34471-9_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-34470-2
Online ISBN: 978-3-030-34471-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)