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Peptide-functionalized Biomaterials with Osteoinductive or Anti-biofilm Activity

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Racing for the Surface

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Abstract

Peptides are short sequences of amino acids. Peptides with biological functionality can be derived from the active domain of proteins or determined from peptide screening experiments. Combined with modern chemical techniques to facilitate peptide synthesis, this leads to peptide modification as an interesting approach to render synthetic biomaterials bioactive. Peptides have been used to functionalize implant surfaces as well as bulk biomaterials, and they can be incorporated within controlled release systems. This chapter considers both osteoinductive peptides and anti-biofilm peptides with the goals to improve bone regeneration and reduce implant-associated infection, respectively.

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Acknowledgments

This work in the research group of the author has been partially supported by the Research Foundation Flanders (FWO), grant number G.0B39.14, and the special research fund of the KU Leuven, grant numbers CREA/13/017 and IDO/13/016. The author also gratefully acknowledges the interesting discussions about peptide-functionalized biomaterials and protein engineering over the years with the members of her research group, particularly Dr. Al Halifa Soultan, Dr. Susanna Piluso, Dr. Abhijith Kudva, Burak Toprakhisar, and Christian Garcia Abrego, as well as her former mentors Prof. Jeffrey Hubbell, Prof. Patrick Stayton, and Prof. Michael Hecht.

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    Jennifer Patterson

  2. Department of Imaging and Pathology, KU Leuven, Leuven, Belgium

    Jennifer Patterson

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Correspondence to Jennifer Patterson .

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Editors and Affiliations

  1. Department of Orthopaedics School of Medicine, West Virginia University, Morgantown, WV, USA

    Bingyun Li

  2. AO Research Institute Davos, Davos Platz, Graubünden, Switzerland

    Thomas Fintan Moriarty

  3. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Thomas Webster

  4. Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

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Patterson, J. (2020). Peptide-functionalized Biomaterials with Osteoinductive or Anti-biofilm Activity. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34471-9_6

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