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Cationic Antimicrobial Coatings with Osteoinductive Properties

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Racing for the Surface

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Abstract

Orthopedic implant-associated infections caused by pathogenic bacteria, especially the Staphylococcus genus, have been a medical and surgical challenge. The infections not only delay the healing process, and have patients suffer from severe pain and even be subjected to re-implantation, but also cause enormous economic losses. It is clear that both a reduction of bacterial infections and acceleration of bone healing are critical to improving the osseointegration of orthopedic implants. Recently, various antibacterial coatings have been employed for the surface modification of orthopedic implants to reduce the bacterial infections. Interestingly, it has been found that some antibacterial coatings, including polycations and metal cations, also possess osteoinductive properties, and thus effectively speed up the healing process. In this chapter, we will shed light on the antibacterial and osteogenic mechanisms of positively charged biomaterials and present some typical cationic antimicrobial coatings with osteoinductive properties in detail.

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Acknowledgments

This work was financially supported by the National Key R&D Program of China (2018YFC1105402 and 2017YFA0207202), the National Natural Science Foundation of China (21706222 and 21875189), Key R&D Program of Jiangsu Province (BE2017740), the open research fund of Key Laboratory for Organic Electronics and Information Displays, and the Fundamental Research Funds for the Central Universities.

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Authors and Affiliations

  1. MIIT Key Laboratory of Flexible Electronics & Shaanxi Key Laboratory of Flexible Electronics, Xi’an Key Laboratory of Flexible Electronics & Xi’an Key Laboratory of Biomedical Materials and Engineering, Xi’an Institute of Flexible Electronics (IFE) & Xi’an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), Xi’an, China

    Qing Song, Yangyang Pei, Xiaoting Ye, Peng Li & Wei Huang

  2. Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, China

    Qing Song & Wei Huang

  3. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, China

    Peng Li & Wei Huang

Authors
  1. Qing Song
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  2. Yangyang Pei
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  3. Xiaoting Ye
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  4. Peng Li
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  5. Wei Huang
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Corresponding author

Correspondence to Peng Li .

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Editors and Affiliations

  1. Department of Orthopaedics School of Medicine, West Virginia University, Morgantown, WV, USA

    Bingyun Li

  2. AO Research Institute Davos, Davos Platz, Graubünden, Switzerland

    Thomas Fintan Moriarty

  3. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Thomas Webster

  4. Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

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Song, Q., Pei, Y., Ye, X., Li, P., Huang, W. (2020). Cationic Antimicrobial Coatings with Osteoinductive Properties. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34471-9_5

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