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Three-Dimensional (3D) and Drug-Eluting Nanofiber Coating for Prosthetic Implants

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Racing for the Surface

Abstract

Failure of osseointegration and implant infection are the two main causes of implant failure and loosening. There is an urgent need for orthopedic implants that promote rapid osseointegration and prevent infection, particularly when placed in bone compromised by disease or physiology of the patients. This chapter reviews current and potential future use of biologic and drug-eluting coatings for orthopedic implants to facilitate osseointegration and prevent implant infection. The potential application of porous and drug-eluting coaxial nanofiber as a means of alternative implant surface coating was discussed.

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Abbreviations

AL:

Aseptic loosening

AMP:

Antimicrobial peptides

CS:

Chondroitin sulfate

DAC:

Defensive antibacterial coating

Doxy:

Doxycycline

ECM:

Extracellular matrices

HA:

Hydroxyapatite

LBL:

Layer-by-layer

MSCs:

Mesenchymal stem cells

NFs:

Nanofibers

PAA:

Poly(acrylic acid)

PCL:

Polycaprolactone

PEO:

Poly(ethylene oxide)

PJI:

Prosthetic joint infection

PLGA:

Poly(lactic-co-glycolic acid)

PVP:

Polyvinyl pyrrolidone

rhBMP-2:

Recombinant human bone morphogenetic protein-2

rhBMP-4:

Recombinant human bone morphogenetic protein-4

THA:

Total hip arthroplasties

Ti:

Titanium

TiColl:

Type-I collagen-coated titanium

TJA:

Total joint arthroplasty

TKA:

Total knee arthroplasties

VEGF165:

Recombinant human vascular endothelial growth factor

β-TCP:

β-tricalcium

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Authors and Affiliations

  1. Department of Biomedical Engineering, Wayne State University/IBIO, Detroit, MI, USA

    Liang Chen & Weiping Ren

  2. John D. Dingell VA Medical Center, Detroit, MI, USA

    Weiping Ren

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  1. Liang Chen
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  2. Weiping Ren
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Correspondence to Weiping Ren .

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Editors and Affiliations

  1. Department of Orthopaedics School of Medicine, West Virginia University, Morgantown, WV, USA

    Bingyun Li

  2. AO Research Institute Davos, Davos Platz, Graubünden, Switzerland

    Thomas Fintan Moriarty

  3. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Thomas Webster

  4. Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

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Chen, L., Ren, W. (2020). Three-Dimensional (3D) and Drug-Eluting Nanofiber Coating for Prosthetic Implants. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34471-9_4

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