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Bimetallic Nanoparticles for Biomedical Applications: A Review

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Racing for the Surface

Abstract

Bimetallic nanoparticles, or BMNPs, are nanosized structures that are of growing interest in biomedical applications. Although their production shares aspects with physicochemical approaches for the synthesis of their monometallic counterparts, they can show a large variety of new properties and applications as a consequence of the synergetic effect between the two components. These applications can be as diverse as antibacterial treatments or anticancer or biological imaging approaches, as well as drug delivery. Nevertheless, utilization of BMNPs in such fields has received limited attention because of the severe lack of knowledge and concerns regarding the use of other nanomaterials, such as stability and biodegradability over time, tendency to form clusters, chemical reactivity, and biocompatibility. In this review, a close look at bimetallic systems is presented, focusing on their biomedical applications as antibacterial, anticancer, drug delivery, and imaging agents, showing significant enhancement of their features compared to their monometallic counterparts and other current used nanomaterials for biomedical applications.

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Author notes

  1. David Medina and Bahram Saleh contributed equally to this work.

Authors and Affiliations

  1. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    David Medina-Cruz, Bahram Saleh, Ada Vernet-Crua & Thomas Webster

  2. Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA

    David Medina-Cruz, Bahram Saleh, Ada Vernet-Crua & Thomas Webster

  3. School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, Nuevo León, Mexico

    Alfonso Nieto-Argüello, Diana Lomelí-Marroquín, Lydia Yerid Vélez-Escamilla & Jorge L. Cholula-Díaz

  4. Instituto de Micro y Nanotecnología, IMN-CNM, CSIC (CEI UAM + CSIC), Tres Cantos, Spain

    José Miguel García-Martín

Authors
  1. David Medina-Cruz
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  2. Bahram Saleh
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  3. Ada Vernet-Crua
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  4. Alfonso Nieto-Argüello
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  5. Diana Lomelí-Marroquín
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  7. Jorge L. Cholula-Díaz
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  8. José Miguel García-Martín
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  9. Thomas Webster
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Corresponding author

Correspondence to Thomas Webster .

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Editors and Affiliations

  1. Department of Orthopaedics School of Medicine, West Virginia University, Morgantown, WV, USA

    Bingyun Li

  2. AO Research Institute Davos, Davos Platz, Graubünden, Switzerland

    Thomas Fintan Moriarty

  3. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Thomas Webster

  4. Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

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Medina-Cruz, D. et al. (2020). Bimetallic Nanoparticles for Biomedical Applications: A Review. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34471-9_16

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