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Animal Models for Bone Tissue Engineering and Osteoinductive Biomaterial Research

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Racing for the Surface

Abstract

Animal bone defect model is the most important and widely used in vivo model for the study of osteoinductive biomaterials and bone tissue engineering. There are many different types of bone defect models at various anatomical sites, including skull and long bones, and using different animals, including mice, rats, rabbits, dogs, swine, and even nonhuman primates. Proper selection of animal model for a specific biomaterial or bone tissue engineering study is critical to obtain reasonable and reliable results. In this chapter, calvarial, weight-bearing long bone segmental defect models, metaphyseal defect models, and vertebral defect models are reviewed referring to several selection criteria of bone defect models. Several issues regarding model selection are discussed, including the characteristics of the model, the material being tested, and the experimental purpose. Considering the inconsistency between the current models and the real clinical conditions, we propose a suggestion for the future development of animal models for bone tissue engineering and osteoinductive biomaterial research.

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Acknowledgements

This work is supported by the National Natural Science Foundation of China (81622032, 51672184 and 81501858), Jiangsu Innovation and Entrepreneurship Program, National Basic Research Program of China (973 Program, 2014CB748600), Suzhou Science and Technology Project (SYS2019022), and the Priority Academic Program Development of Jiangsu High Education Institutions (PAPD).

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  1. Qifeng Lu and Xiao Lin contributed equally to this work.

Authors and Affiliations

  1. Orthopaedic Institute and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China

    Qifeng Lu, Xiao Lin & Lei Yang

  2. Center for Health Science and Engineering (CHSE), School of Materials Science and Engineering, Hebei University of Technology, Tianjin, China

    Lei Yang

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  1. Qifeng Lu
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  2. Xiao Lin
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Correspondence to Lei Yang .

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Editors and Affiliations

  1. Department of Orthopaedics School of Medicine, West Virginia University, Morgantown, WV, USA

    Bingyun Li

  2. AO Research Institute Davos, Davos Platz, Graubünden, Switzerland

    Thomas Fintan Moriarty

  3. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Thomas Webster

  4. Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

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Lu, Q., Lin, X., Yang, L. (2020). Animal Models for Bone Tissue Engineering and Osteoinductive Biomaterial Research. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34471-9_11

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