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Notch Signaling in Embryology and Cancer pp 59–75Cite as

Epigenetic Regulation of Notch Signaling During Drosophila Development

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1218))

Abstract

Notch signaling exerts multiple important functions in various developmental processes, including cell differentiation and cell proliferation, while mis-regulation of this pathway results in a variety of complex diseases, such as cancer and developmental defects. The simplicity of the Notch pathway in Drosophila melanogaster, in combination with the availability of powerful genetics, makes this an attractive model for studying the fundamental mechanisms of how Notch signaling is regulated and how it functions in various cellular contexts. Recently, increasing evidence for epigenetic control of Notch signaling reveals the intimate link between epigenetic regulators and Notch signaling pathway. In this chapter, we summarize the research advances of Notch and CAF-1 in Drosophila development and the epigenetic regulation mechanisms of Notch signaling activity by CAF-1 as well as other epigenetic modification machineries, which enables Notch to orchestrate different biological inputs and outputs in specific cellular contexts.

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Authors and Affiliations

  1. Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China

    Chuanxian Wei, Chung-Weng Phang & Renjie Jiao

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  1. Chuanxian Wei
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  2. Chung-Weng Phang
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Correspondence to Renjie Jiao .

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  1. Department of Dermatology, The Saarland University Hospital, Homburg, Saarland, Germany

    Jörg Reichrath

  2. Department of Dermatology, The Saarland University Hospital, Homburg, Saarland, Germany

    Sandra Reichrath

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Wei, C., Phang, CW., Jiao, R. (2020). Epigenetic Regulation of Notch Signaling During Drosophila Development. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 1218. Springer, Cham. https://doi.org/10.1007/978-3-030-34436-8_4

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