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The Impact of Processing on Potentially Beneficial Wheat Grain Components for Human Health

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Wheat Quality For Improving Processing And Human Health

Abstract

Wheat based foods, mainly in the form of bread and pasta, are staples of the human diet in many countries around the world. The dry weight of mature wheat grain is composed of 70–75% starch and around 10–14% protein, which has led to the widespread perception of wheat foods as sources of energy and protein. However, whole grains are also important sources of dietary fiber, vitamins and minerals, and contain notable levels of bioactive compounds with potential health benefits like lignans, phenolic acids, alkylresorcinols, phytosterols, folates and tocols.

The prominence of wheat grain in the human diet is largely due to its versatility in being processed into diverse products like flour, semolina, and other bakery products. Processing is a pre-requisite for using cereal grains as food and obtaining end products with various unique properties that are safe and appealing to consume. Processing may also help reduce the amount of hazardous molecules potentially present in harvested wheat, such as pesticides, mycotoxins and heavy metals. Each regulated step in a processing series influences the composition and/or the physicochemical properties of the different grain components, which in turn define the technological quality and the nutritional and health promoting properties of the end product.

The unique textural properties of wheat foods are largely determined by the starch and gluten proteins present in the starchy endosperm, the main constituents of white flour and semolina. The health-promoting effects of wheat-based products are mainly associated with the dietary fiber and bioactive compounds that are enriched in the grain peripheral layers, and mainly the aleurone layer, which is generally a component of the bran fraction after milling. Fractionation by milling and the way the different milling streams are subsequently recombined therefore has a considerable impact on the relative abundance of each grain component in the wheat flour/semolina and, consequently, in end products. Further processing steps, such as dough making, microbial fermentation, extrusion, and baking can also affect the relative amounts and bioavailability of grain components. Some examples of the effects of grain processing procedures on the bioavailability of important grain components in wheat foods consumed by humans will be presented in this chapter. Suggestions of how to improve these processes in light of the implications for human health will also be discussed.

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References

  • Abbaspour N, Richard Hurrell R, Kelishadi R (2014) Review on iron and its importance for human health. J Res Med Sci 19: 164–174.

    PubMed  PubMed Central  Google Scholar 

  • Abdel-Aal E-SM, Hucl P (1999) A rapid method for quantifying total anthocyanins in blue and purple pericarp wheats. Cereal Chem 76: 350–354.

    Article  CAS  Google Scholar 

  • Abdel-Aal E-SM, Hucl P (2003) Composition and stability of anthocyanins in blue-grained wheat. J Agric Food Chem 51: 2174–2180.

    Article  CAS  Google Scholar 

  • Abdel-Aal E-SM, Young JC, Rabalski I, Hucl P, Fregeau-Reid J (2007) Identification and quantification of seed carotenoids in selected wheat species. J Agric Food Chem 55: 787–794.

    Article  CAS  Google Scholar 

  • Adam A, Crespy V, Levrat-Verny M-A Leenhardt F, Leuillet M, Demigne C et al (2002) The Bioavailability of Ferulic Acid Is Governed Primarily by the Food Matrix Rather than Its Metabolism in Intestine and Liver in Rats. J Nutrition 137: 1962–68.

    Article  Google Scholar 

  • Adhikari KB, Tanwir F, Gregersen P, Steffensen SK, Jensen BM, Poulsen LK et al. (2015) Benzoxazinoids: Cereal phytochemicals with putative therapeutic and health-protecting properties. Mol Nutr and Food Res. 59: 1324–1338.

    Article  CAS  Google Scholar 

  • Aehle E, Müller U, Eklund PC, Willfor S M, Sippl W, Dräger B (2011) Lignans as food constituents with estrogen and antiestrogen activity. Phytochem 72: 2396–2405.

    Article  CAS  Google Scholar 

  • Andersson AAM, Aman P, Wandel M, Frølich W (2010a) Alkylresorcinols in wheat and rye flour and bread. J Food Composition and Analysis 23: 794–801.

    Article  CAS  Google Scholar 

  • Andersson AAM, Andersson R, Piironen V Lampi A-M, Nystrom L, Boros D et al. (2013) Contents of dietary fibre components and their relation to associated bioactive components in whole grain wheat samples from the HEALTHGRAIN diversity screen. Food Chem 136: 1243–1248.

    Article  CAS  PubMed  Google Scholar 

  • Andersson AAM, Dinberg L, Aman P, Landberg R (2014) Recent findings on certain bioactive components in whole grain wheat and rye. J Cereal Sci 59: 294–311.

    Article  CAS  Google Scholar 

  • Andersson Y, Hedlund B, Jonsson L, Svensson S (1981) Extrusion cooking of a high-fiber cereal product with crispbread character. Cereal Chem 58: 370–374.

    CAS  Google Scholar 

  • Andersson AAM, Kamal-Eldin AK-E, Aman P (2010b) Effects of Environment and variety on Alkylresorcinols in Wheat in the HealthGrain Diversity screen. J Agric Food Chem 58: 9299–9305.

    Article  CAS  PubMed  Google Scholar 

  • Andersson AAM, Kamal-Eldin AK-E, Fra A, Boros D, Aman P (2008). Alkylresorcinols in wheat varieties in the HealthGrain Diversity screen. J Agric Food Chem 56: 9722–9725.

    Article  CAS  PubMed  Google Scholar 

  • Andersson SW, Skinner J, Ellegard, Welch A A, Bingham S, Mulligan A, Andersson H, Khaw K-T (2004) Intake of dietary plant sterols is inversely related to serum cholesterol concentration in men and women in the EPIC Norfolk population: a cross-sectional study. Eur J Clinical Nutr 58: 1378–1385.

    Article  CAS  Google Scholar 

  • Andreasen MF, Kroon PA, Williamson G, Garcia-Conesa MT (2001) Intestinal release and uptake of phenolic antioxidant diferulic acids. Free Radic Biol Med 31: 304–314.

    Article  CAS  PubMed  Google Scholar 

  • Anson NM, Selinheimo E, Havenaar R, Aura AM et al (2009b) Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds. J Agric Food Chem 57: 6148–55.

    Article  CAS  PubMed  Google Scholar 

  • Anson NM, van den Berg R, Havenaar R, Bast A, Haenen G R (2008) Ferulic acid from aleurone determines the antioxidant potency of wheat grain (Triticum aestivum L.). J Agric Food Chem 56: 5589–5594.

    Article  CAS  Google Scholar 

  • Anson NM, van den Berg R, Havenaar R, Bast A, Haenen, G R M M (2009a) Bioavailability of ferulic acid is determined by its bioaccessibility. J Cereal Sci 49: 296–300.

    Article  CAS  Google Scholar 

  • Antoine C, Peyron S, Mabille F, Lapierre C, .Bouchet B, Abecassis J, Rouau X (2003) Individual contribution of grain outer layers and their cell wall structure to the mechanical properties of wheat bran. J Agric Food Chem 51: 2026–2033.

    Article  CAS  PubMed  Google Scholar 

  • Axelson M, Sjövall J, Gustafsson B E, Setchel, KDR (1982) Origin of lignans in mammals and identification of a precursor from plants. Nature 298: 659–660.

    Article  CAS  PubMed  Google Scholar 

  • Bacic A, Stone BA (1981) Chemistry and organisation of aleurone cell wall components from wheat and barley. Austr J Plant Phys 8: 475–49.

    CAS  Google Scholar 

  • Balmer Y, Vensel W H, DuPont F-M, Buchanan B B, Hurkman W J (2006) Proteome of amyloplasts isolated from developing wheat endosperm presents evidence of broad metabolic capability. J Exp Botany 57: 1591–1602.

    Article  CAS  Google Scholar 

  • Barron C, Samson M-F, Lullien-Pellerin V, Rouau X (2011) Wheat grain tissue proportions in milling fractions using biochemical marker measurements: Application to different wheat cultivars. J Cereal Sci 53: 306–311.

    Article  CAS  Google Scholar 

  • Barron C, Surget A, Rouau X (2007) Relative amounts of tissues in mature wheat (Triticum aestivum L.) grain and their carbohydrate and phenolic acid composition. J Cereal Sci 45:88–96.

    Article  CAS  Google Scholar 

  • Bartnik M, Szafranska I (1987) Changes in phytate content and phytase activity during the germination of some cereals. J Cereal Sci 5: 23–28.

    Article  CAS  Google Scholar 

  • Batifoulier F, Verny M–A, Chanliaud E, Rémésy C, Demigné C (2005) Effect of different breadmaking methods on thiamine, riboflavin and pyridoxine contents of wheat bread. J Cereal Sci 42: 101–108.

    Article  CAS  Google Scholar 

  • Batifoulier F, Verny M–A, Chanliaud E, Rémésy C, Demigné C (2006) Variability of B vitamin concentrations in wheat grain, milling fractions and bread products. Europ J Agronomy 25: 163–169.

    Article  CAS  Google Scholar 

  • Beleggia R, Platani C, Nigro F, De Vita P, Cattivelli L, Papa R (2013) Effect of genotype, environment and genotype-by environment interaction on metabolite profiling in durum wheat (Triticum durum desf.) grain. J Cereal Sci 57: 183–192.

    Article  CAS  Google Scholar 

  • Beleggia R, Platani C, Papa R, Di Chio A, Barros E, Mashaba C et al (2011) Metabolomics and food processing: from semolina to pasta. J Agric Food Chem 59: 9366–9377.

    Article  CAS  PubMed  Google Scholar 

  • Berry CS (1986) Resistant starch: formation and measurement of starch that survives exhaustive digestion with amylolytic enzymes during the determination of dietary fibre. J Cereal Sci 4: 301–314.

    Article  CAS  Google Scholar 

  • Beta T, Nam S, Dexter J E, Sapirstein HD (2005) Phenolic content and antioxidant activity of pearled wheat and roller-milled fractions. Cereal Chem 82: 390–393.

    Article  CAS  Google Scholar 

  • Biesiekierski JR, Peters S L, Newnham ED, Rosella O, Muir JG, Gibson PR (2013) No Effects of Gluten in Patients With Self-Reported Non-Celiac Gluten Sensitivity After Dietary Reduction of Fermentable, Poorly Absorbed, Short-Chain Carbohydrates. Gastroenterology 145: 320–328.

    Article  CAS  PubMed  Google Scholar 

  • Björck I, Nyman M, Asp N-G (1984) Extrusion cooking and dietary fibre: Effects on dietary fibre content and on degradation in the rat intestinal tract. Cereal Chem 61: 174–179.

    Google Scholar 

  • Blandino M, Sovrani V, Marinaccio F, Reyneri A, Rolle L, Giacosa S et al. (2013) Nutritional and technological quality of bread enriched with an intermediate pearled wheat fraction. Food Chem 141: 2549–2557.

    Article  CAS  PubMed  Google Scholar 

  • Böhmdorfer S, Oberlerchner JT, Fuchs C, Rosenau T, Grausgruber H (2018) Profiling and quantification of grain anthocyanins in purple pericarp × blue aleurone wheat crosses by high-performance thin-layer chromatography and densitometry. Plant Methods 14: 29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bordiga M, Locatelli M, Travaglia F, Arlorio M (2016) Alkylresorcinol content in whole grains and pearled fractions of wheat and barley. J Cereal Sci 70: 38–46.

    Article  CAS  Google Scholar 

  • Borrelli GM, De Leonardis AM, Fares, Platani C, DiFonzo N (2003) Effects of modified processing conditions on oxidative properties of semolina dough and pasta. Cereal Chem 80: 225–231.

    Article  CAS  Google Scholar 

  • Brandolini A, Hidalgo A, Gabriele S, Heun M (2015) Chemical composition of wild and feral diploid wheats and their bearing on domesticated wheats. J Cereal Sci 63: 122–127.

    Article  CAS  Google Scholar 

  • Brandolini A, Hidalgo A, Moscaritolo S (2008) Chemical composition and pasting properties of einkorn (Triticum monococcum L., subsp monococcum) whole meal flour. J Cereal Sci 47: 599–609.

    Article  CAS  Google Scholar 

  • Brighenti F, Cristina M, Baggio C (1998) Resistant starch in Italian diet. British J Nutr 80: 333–41.

    CAS  Google Scholar 

  • Britton G (1995) Structure and properties of carotenoids in relation to function. FASEB J 9: 1551–1558.

    Article  CAS  PubMed  Google Scholar 

  • Brown G, Gordon S (2001) Immune recognition: a new receptor for β-glucans. Nature 413: 36–37.

    Article  CAS  PubMed  Google Scholar 

  • Brownlee IA (2011) The physiological roles of dietary fibre. Food Hydrocolloids 25: 238–250.

    Article  CAS  Google Scholar 

  • Buchmann CA, Nersesyan A, Kopp B, Schauberger D, Darroudi F, Grummt T et al. (2007) Dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA), two naturally occurring benzoxazinones contained in sprouts of Gramineae are potent aneugens in human-derived liver cells (HepG2). Cancer Letters 246: 290–299.

    Article  CAS  PubMed  Google Scholar 

  • Bunzel M, Ralph J, Lu F, Hatfield RD, Steinhart, H (2004) Lignins and ferulate-coniferyl alcohol cross-coupling products in cereal grains. J Agric Food Chem 52: 6496–6502.

    Article  CAS  PubMed  Google Scholar 

  • Buttriss L, Stokes CS (2008) “Dietary Fibre and Health: An Overview,” Nutrition Bulletin 33: 186–200.

    Article  Google Scholar 

  • Capek P, Matulová M (2013) An arabino(glucurono)xylan isolated from immunomodulatory active hemicellulose fraction of Salvia officinalis L. Int J Biol Macromol 59: 396–401.

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Ross A, Aman P, Kamal-Eldin, A (2004) Alkylresorcinols as markers of whole grain wheat and rye in cereal products. J of Food Agric Chem 52: 8242–8246.

    Article  CAS  Google Scholar 

  • Cleemput G, Booij C, Hessing M, Gruppen H, Delcour J A (1997) Solubilisation and changes in molecular weight distribution of arabinoxylans and protein in wheat flours during bread-making, and the effects of endogenous arabinoxylan hydrolysing enzymes. J Cereal Sci 26: 55–66.

    Article  CAS  Google Scholar 

  • Comino P, Collins H, Lahnstein J, Gidley M J (2016) Effects of diverse food processing conditions on the structure and solubility of wheat, barley and rye endosperm dietary fibre. J Food Engineering 169: 228–237.

    Article  Google Scholar 

  • Cooper DN, Kable ME, Marco ML, De Leon A, Rust B, Baker JE et al. (2017) The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota. Nutrients. 9: 173.

    Article  CAS  PubMed Central  Google Scholar 

  • Corol DI, Ravel C, Raksegi M, Charmet G, Beale MH, Shewry PR, Ward JL (2012) Effects of genotype and environment on the contents of betaine, choline and trigonelline in cereal grains. J Agric Food Chem 60: 5471–5481.

    Article  CAS  PubMed  Google Scholar 

  • Cubadda F, Aureli F, Raggi A, Carcea M (2009) Effect of milling, pasta making and cooking on minerals in durum wheat. J Cereal Sci. 49: 92–7.

    Article  CAS  Google Scholar 

  • Das A, Raychaudhuri U, Chakraborty R (2012) Cereal based functional food of Indian subcontinent: a review. J Food Sci Tech. 49: 665–672.

    Article  CAS  Google Scholar 

  • Davin LB, Jourdes M, Patten A M, Kim KW, Vassão D G, Lewis N et al. (2008) Dissection of lignin macromolecular configuration and assembly: comparison to related biochemical processes in allyl/propenyl phenol and lignan biosynthesis. Natural Product Reports 25: 1015–90.

    Article  CAS  PubMed  Google Scholar 

  • Davis KR, Cain RF, Peters LJ, Tourneau DL, McGinnis J (1981) Evaluation of the nutrient composition of wheat II. Proximate analysis, thiamine, riboflavin, niacin and pyridoxine. Cereal Chem 58: 116–120.

    CAS  Google Scholar 

  • DiNicolantonio JJH, O’Keefe J, Wilson W (2018) Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis Open Heart 5: e000668.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dornez E, Gebruers K, Wiame S, Delcour JA, Courtin CM (2006) Insight into the distribution of arabinoxylans, endoxylanases, and endoxylanase inhibitors in industrial wheat roller mill streams. J. Agr. Food Chem. 54: 8521–8529.

    Article  CAS  Google Scholar 

  • Drankham K, Carter J, Madl R, Klopfenstein C, Padula F, Lu Y et al. (2003) Antitumor activity of wheats with high orthophenolic content. Nutr Cancer 47: 188–194.

    Article  Google Scholar 

  • Durazzo A, Azzini E, Raguzzini A, Maiani, G, Finocchiaro F, Ferrari B et al. (2009) Influence of processing on the lignans content of cereal based foods. Tecnica Molitoria International 60: 163–173.

    Google Scholar 

  • Durazzo A, Azzini E, Turfani V, Polito A, Maiani G, Carcea M (2013) Effect of cooking on lignans content in whole-grain pasta made with different cereals and other seeds. Cereal Chem 90: 169–171.

    Article  CAS  Google Scholar 

  • Eagling T, Neal AL, McGrath SP, Fairweather-Tait S, Shewry PR, Zhao F-J (2014b) Distribution and speciation of iron and zinc in grain of two wheat genotypes. J Agric Food Chem 62: 708–716.

    Article  CAS  PubMed  Google Scholar 

  • Eagling T, Wawer A, Shewry P R, Zhao F J, Fairweather-Tait S (2014a) Iron Bioavailability in Two Commercial Cultivars of Wheat: Comparison between Wholegrain and White Flour and the Effects of Nicotianamine and 2′-Deoxymugineic Acid on Iron Uptake into Caco-2 Cells. J Agric Food Chem 62: 10320–10325.

    Article  CAS  PubMed  Google Scholar 

  • Eerlingen RC, Deceuninck M, Delcour JA (1993) Enzyme resistant starch II: Influence of amylose chain length on resistant starch formation. Cereal Chem 70: 345–350.

    CAS  Google Scholar 

  • Eerlingen RC, Jacobs H, Delcour JA (1994) Enzyme- resistant starch V. Effect of retrogradation of waxy maize starch on enzyme susceptibility. Cereal Chem 71: 351–355.

    CAS  Google Scholar 

  • Escalante-Aburto A, Ramírez-Wong B, Torres-Chávez PI Figueroa-Cardenas JD, Lopez-Cervantes J, Barron-Hoyos JM et al (2013) Effect of extrusion processing parameters on anthocyanin content and physicochemical properties of nixtamalized blue corn expanded extrudates. CyTA - J Food 11: 29–37.

    Article  CAS  Google Scholar 

  • Escribano-Bailòn MT, Santos-Buelga C, Rivas-Gonzalo JC (2004) Anthocyanins in cereals. J Chromatrogr A 1054: 129–141.

    Article  CAS  Google Scholar 

  • Evers AD, Blakeney AB, O’Brien LO (1999) Cereal structure and composition. Aust J Agric Res 50, 629–650.

    Article  Google Scholar 

  • Fenech M, Noakes M, Clifton P, Topping D (1999) Aleurone flour is a rich source of bioavailable folate in humans. J Nutr 129: 1114–1119.

    Article  CAS  PubMed  Google Scholar 

  • Ficco DBM, De Simone V, Colecchia SA, Pecorella I, Platani C et al. (2014) Genetic variability in anthocyanin composition and nutritional properties of blue, purple, and red bread (Triticum aestivum L.) and durum (Triticum turgidum L. ssp. turgidum convar. durum) wheats. J Agric Food Chem 62: 8686–8695.

    Article  CAS  PubMed  Google Scholar 

  • Fratianni A, Di Criscio T, Mignogna R, Panfili G (2012) Carotenoids, tocols and retinols evolution during egg pasta–making processes Food Chem 131: 590–595.

    Article  CAS  Google Scholar 

  • Galliard T (1989) Rancidity in cereal products. In: Allen JC and Hamilton R J (eds), Rancidity in Foods, 2nd ed. Elsevier, London, p 141–157.

    Google Scholar 

  • Gardner HW (1988) Lipoxygenase pathways in cereals. In: Pomeranz Y (ed). Advances in cereal science and technology, vol 9. American Association of Cereal Chemists, St. Paul, MN, USA, p 161–215.

    Google Scholar 

  • Garg M, Chawla M, Chunduri V, Kumar R, Sharma S et al. (2016) Transfer of grain colors to elite wheat cultivars and their characterization J Cereal Sci 71: 138–144.

    Article  Google Scholar 

  • Gelinas P, McKinnon C, Gagnon F (2015) Fructans, water-soluble fibre and fermentable sugars in bread and pasta made with ancient and modern wheat. Intern J Food Sci and Technol 51: 555–564.

    Article  CAS  Google Scholar 

  • Gibson PR, Shepherd SJ (2005) Personal view: food for thought – western lifestyle and susceptibility to Crohn’s disease. The FODMAP hypothesis. Aliment Pharmacol Ther 21: 1399–1409.

    Article  CAS  PubMed  Google Scholar 

  • Graham SF, Holis JH, Migaud M, Browne RA (2009). Analysis of Betaine and Choline Contents of Aleurone, Bran, and Flour Fractions of Wheat (Triticum aestivum L.) Using 1H Nuclear Magnetic Resonance (NMR) Spectroscopy. J Agric Food Chem 57: 1948–1951.

    Article  CAS  PubMed  Google Scholar 

  • Greffeuille V, Abecassis J, Bar L’Helgouac’h C, Lullien-Pellerin V (2005) Differences in the aleurone layer fate between hard and soft common wheats at grain milling. Cereal Chem 82: 138–143.

    Article  CAS  Google Scholar 

  • Gujska E, Majewska K (2005) Effect of baking process on added folic acid and endogenous folates stability in wheat and rye breads. Plant Foods Hum Nutr 60: 37–42.

    Article  CAS  PubMed  Google Scholar 

  • Gupta RK, Gangoliya SS, Singh NK (2015) Screening and Characterization of Wheat Germplasms for Phytic Acid and Iron Content J. Agr. Sci. Tech. 17: 747–756.

    Google Scholar 

  • Håkansson B, Jägerstad M, öste R, Åkesson B, Jonsson L (1987) The effects of various thermal processes on protein quality, vitamins and selenium content in whole grain wheat and white flour. J. Cereal Sci. 6: 269

    Google Scholar 

  • Håkansson B, Jägerstad M (1990) The effect of thermal inactivation of lipoxygenase on the stability of vitamin E in wheat. J Cereal Sci. 12: 177–185.

    Article  Google Scholar 

  • Hallström E, Sestili F, Lafiandra D, Björck I,Östman E (2011) A novel wheat variety with elevated content of amylose increases resistant starch formation and may beneficially influence glycaemia in healthy subjects Food Nutr Res 55: https://doi.org/10.3402/fnr.v55i0.7074

  • Han H-M, Koh B-K (2011) Antioxidant activity of hard wheat flour, dough and bread prepared using various processes with the addition of different phenolic acids. J Sci Food Agr 91: 604–608.

    Article  CAS  Google Scholar 

  • Hansen HB, Andreasen MF, Nielsen MM, Larsen LM, Knudsen KEB, Meyer AS et al. (2002) Changes in dietary fibre, phenolic acids and activity of endogenous enzymes during rye bread-making. European Food Res and Technol 214: 33–42.

    Article  CAS  Google Scholar 

  • Hashimoto Y, Shudo K (1996) Chemistry of biologically active benzoxazinoids. Phytochem 43, 551–559.

    Article  CAS  Google Scholar 

  • Haska L, Nyman M, Andersson R (2008) Distribution and characterisation of fructan in wheat milling fractions. J Cereal Sci 48: 768–774.

    Article  CAS  Google Scholar 

  • Hefni M, Witthoft CM (2012) Enhancement of the folate content in Egyptian pita bread. Food & Nutrition Research. 56: 5566.

    Article  CAS  Google Scholar 

  • Hemery Y, Lullien-Pellerin V, Rouau X, Abecassis J, Samson M-F, Åman P et al. (2009) Biochemical markers: Efficient tools for the assessment of wheat grain tissue proportions in milling fractions. J. Cereal Sci. 49: 55–64.

    Article  CAS  Google Scholar 

  • Hemery Y, Rouau X, Lullien-Pellerin V, Barron C, Abecassis J (2007) Dry processes to develop wheat fractions and products with enhanced nutritional quality. J Cereal Sci 46: 327–347.

    Article  CAS  Google Scholar 

  • Henkin RI (1984) Zinc in taste function - a critical review. Biol Trace Elem Res 6: 263–280.

    Article  CAS  PubMed  Google Scholar 

  • Hidalgo A, Brandolini A (2008a) Kinetics of carotenoids degradation during the storage of einkorn (Triticum monococcum L. ssp. monococcum) and breadwheat (Triticum aestivum L. ssp. aestivum) flours. J Agric Food Chem 56: 11300–11305.

    Article  CAS  PubMed  Google Scholar 

  • Hidalgo A, Brandolini A (2008b) Protein, ash, lutein and tocols distribution in einkorn (Triticum monococcum L. subsp. monococcum) seed fractions. Food Chem 107: 444–448.

    Article  CAS  Google Scholar 

  • Hidalgo A, Brandolini A (2012) Lipoxygenase activity in whole meal flours from Triticum monococcum, Triticum turgidum and Triticum aestivum. Food Chem 131: 1499–1503.

    Article  CAS  Google Scholar 

  • Hidalgo A, Brandolini A (2017) Nitrogen fertilisation effects on technological parameters and carotenoid, tocol and phenolic acid content of einkorn (Triticum monococcum L. subsp. monococcum): A two-year evaluation. J Cereal Sci 73: 18–24.

    Article  CAS  Google Scholar 

  • Hidalgo A, Brandolini A, Pompei C (2010) Carotenoids evolution during pasta, bread and water biscuit preparation from wheat flours. Food Chem 121: 746–751.

    Article  CAS  Google Scholar 

  • Hidalgo A, Brandolini A, Pompei C, Piscozzi R (2006) Carotenoids and tocols of einkorn wheat (Triticum monococcum ssp monococcum L.). J Cereal Sci 44: 182–193.

    Article  CAS  Google Scholar 

  • Hidalgo A, Brandolini A, Ratti S (2009) Influence of genetic and environmental factors on selected nutritional traits of Triticum monococcum. J Agric Food Chem 57: 6342–6348.

    Article  CAS  PubMed  Google Scholar 

  • Hidalgo A, Fongaro L, Brandolini A (2014) Wheat flour granulometry determines colour perception. Food Res Int 64: 363–370.

    Article  PubMed  Google Scholar 

  • Huang Z, Dostal L, Rosazza JPN (1993) Microbial transformations of ferulic acid by Saccharomyces cerevisiae and Pseudomonas fluorescens. Appl. Environ. Microbiol. 59: 2244–2250.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huynh B-L, Lachlan P, Mather DE, Wallwork H, Graham RD, Welch RM, Stangoulis JCR (2008) Genotypic variation in wheat grain fructan content revealed by a simplified HPLC method. J Cereal Sci 48: 369–378.

    Article  CAS  Google Scholar 

  • Iiyama K, Lam TB-T, Stone BA (1994) Covalent Cross-Links in the Cell Wall. Plant Physiol. 104: 315–320.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Irmak S, Dunford NT, Milligan J (2006) Policosanol contents of beeswax, sugar cane and wheat extracts. Food Chem 95: 312–318.

    Article  CAS  Google Scholar 

  • Jaafar SNS, Baron J, Siebenhandl-Ehn S, Rosenau T, Böhmdorfer S, Grausgruber H (2013) Increased anthocyanin content in purple pericarp ⨯ blue aleurone wheat crosses. Plant Breeding 132: 546–552.

    Article  CAS  Google Scholar 

  • Jenkins DJA, Wolever TMS, Collier G R (1987) Metabolic effects of a low-glycemic-index diet. Am J Clin Nutr 46: 968–75.

    Article  CAS  PubMed  Google Scholar 

  • Kamal-Eldin A, Appelqvist LA (1996) The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31: 671–701.

    Article  CAS  PubMed  Google Scholar 

  • Keagy PM, Borenstein B, Ranum P, Connor MA, Lorenz K, Hobbs WE et al. (1980) Natural levels of nutrients in commercially milled wheat flours. Cereal Chem 57: 59–65.

    CAS  Google Scholar 

  • Keaveney EM, Price R K, Hamill LL, Wallace JMW, McNulty H, Ward M et al. (2015) Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread. British J Nutrition 113: 445–453.

    Article  CAS  Google Scholar 

  • Kern SM, Bennett RN, Mellon FA, Kroon PA, Garcia-Conesa MT (2003) Absorption of hydroxycinnamates in humans after high-bran cereal consumption. J Agric Food Chem 51: 6050–55.

    Article  CAS  PubMed  Google Scholar 

  • Kiyama R (2016) Biological effects induced by estrogenic activity of lignans. Trends Food Sci Technol 54: 186–196.

    Article  CAS  Google Scholar 

  • Klepacka J, Fornal L (2006) Ferulic acid and its position among the phenolic compounds of wheat. Critical Reviews in Food Science and Nutrition 46: 639–647.

    Article  CAS  PubMed  Google Scholar 

  • Knievel DC, Abdel-Aal E-SM, Rabalski I, Nakamura T, Hucl P (2009) Grain color development and the inheritance of high anthocyanin blue aleurone and purple pericarp in spring wheat (Triticum aestivum L.). J Cereal Sci 50: 113–120.

    Article  CAS  Google Scholar 

  • Knudsen KEB (1997) Carbohydrate and lignin contents of plant materials used in animal feeding. Animal Feed Science Technology 67: 319–338.

    Article  Google Scholar 

  • Koehler P, Hartmann G, Wieser H, Rychlik M (2007) Changes of folates, dietary fiber, and proteins in wheat as affected by germination. J Agric Food Chem 55: 4678–4683.

    Article  CAS  PubMed  Google Scholar 

  • Kong J-M, Chia L-S, Goh N-K, Chia T-F, Brouillard R (2003) Analysis and biological activities of anthocyanins. Phytochem 64: 923–933.

    Article  CAS  Google Scholar 

  • Konopka I, Tańska M, Faron A, Czaplicki S (2014) Release of Free Ferulic Acid and Changes in Antioxidant Properties during the Wheat and Rye Bread Making Process. Food Sci Biotechnol 23: 831–840.

    Article  CAS  Google Scholar 

  • Kozubek A, Nienartowicz B (1995) Cereal grain resorcinolic lipids inhibit H2O2-induced peroxidation of biological membranes. Acta Biochim Pol 42: 309–3015.

    Google Scholar 

  • Kozubek A, Tyman JHP (1999) Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity. Chem Rev 99: 1–25.

    Google Scholar 

  • Krinsky NI (1994) The biological properties of carotenoids. Pure Appl Chem 66: 1003–1010.

    Article  Google Scholar 

  • Kristensen M, Toubro S, Jensen MG, Ross AB, Riboldi G, Petronio M et al. (2012) Whole grain compared with refined wheat decreases the percentage of body fat following a 12-week, energy-restricted dietary intervention in postmenopausal women. J Nutr. 142: 710–716.

    Article  CAS  PubMed  Google Scholar 

  • Krüger S, Morlock GE (2018) Fingerprinting and characterization of anthocyanins in 94 colored wheat varieties and blue aleurone and purple pericarp wheat crosses. J Chromatogr A 1538: 75–85.

    Article  CAS  PubMed  Google Scholar 

  • Kumar V, Sinha A K, Makkar HPS, Becker K (2010) Dietary roles of phytate and phytase in human nutrition: a review. Food Chem 120: 945–959.

    Article  CAS  Google Scholar 

  • Lachman J, Hejtmankova K, Kotikova Z (2013) Tocols and carotenoids of einkorn, emmer and spring wheat varieties: selection for breeding and production. J Cereal Sci 57: 207–214.

    Article  CAS  Google Scholar 

  • Laddomada B, Caretto S, Mita G (2015) Wheat Bran Phenolic Acids: Bioavailability and Stability in Whole Wheat-Based Foods. Molecules 20: 15666–15685.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lampi AM, Nurmi T, Ollilainen V, Piironen V (2008) Tocopherols and tocotrienols in wheat genotypes in the HEALTHGRAIN Diversity Screening. J Agric Food Chem 56: 9716–21.

    Article  CAS  PubMed  Google Scholar 

  • Landberg R, Kamal-Eldin A, Andersson R, Aman P (2006) Alkylresorcinol Content and Homologue Composition in Durum Wheat (Triticum durum) Kernels and Pasta Products. J Agric Food Chem 54: 3012–3014.

    Article  CAS  PubMed  Google Scholar 

  • Landberg R, Kamal-Eldin A, Salmenkallio-Marttila M, Rouau X, Aman P (2008) Localization of alkylresorcinols in wheat, rye and barley kernels. J Cereal Sci 48: 401–406.

    Article  CAS  Google Scholar 

  • Landberg R, Marklund M, Kamal-Eldin A, Aman P (2014) An update on alkylresorcinols – Occurrence, bioavailability, bioactivity and utility as biomarkers. J of Functional Foods 7: 77–89.

    Article  CAS  Google Scholar 

  • Landete JM (2012) Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health. Food Research International 46: 410–424.

    Article  CAS  Google Scholar 

  • Lebiedzińska A, Marszałł ML, Grembecka M, Czaja J, Szefer P, Kuta J et al. (2018) Detection of B6 vitamers in grain products: experimental and computational studies. Food Anal Methods 11: 725–732.

    Article  Google Scholar 

  • Leenhardt F, Levrat-Verny M-A, Chanliaud E, Rémésy C (2005) Moderate Decrease of pH by Sourdough Fermentation Is Sufficient to Reduce Phytate Content of Whole Wheat Flour through Endogenous Phytase Activity. J Agric Food Chem 53: 98–102.

    Article  CAS  PubMed  Google Scholar 

  • Leenhardt F, Lyan B, Rock E, Boussard A, Potus J, Chanliaud E, Remesy C (2006) Wheat lipoxygenase activity induces greater loss of carotenoids than vitamin E during breadmaking. J Agric Food Chem 54, 1710–1715.

    Article  CAS  PubMed  Google Scholar 

  • Li W, Cui SW, Kakuda Y (2006) Extraction, fractionation, structural and physical characterization of wheat β-D-glucans. Carbohydrate Polymers 63: 408–416.

    Article  CAS  Google Scholar 

  • Lineback DR, Rasper VF (1988) In: Pomeranz Y (ed). Wheat Chemistry and Technology. American Association of Cereal Chemists Inc., St Paul, p. 277–372.

    Google Scholar 

  • Liu Q, Qiu Y, Beta T (2010) Comparison of antioxidant activities of different colored wheat grains and analysis of phenolic compounds. J Sci Food Agric 58: 9235–9241.

    Article  CAS  Google Scholar 

  • Luo YW, Xie W-H, Qian JX Wang, He, Y-J (2014) Effects of germination on iron, zinc, calcium, manganese, and copper availability from cereals and legumes. J Food 12: 22–26.

    CAS  Google Scholar 

  • Magallanes-López AM, Hernandez-Espinosa N, Velu G, Posadas-Romano G, Ordoñez-Villegas VM G, Crossa J et al. (2017) Variability in iron, zinc and phytic acid content in a worldwide collection of commercial durum wheat cultivars and the effect of reduced irrigation on these traits. Food Chem 237: 499–505.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mandalari G, Faulds C, Sancho A, Saija A, Bisignano G, LoCurto R, Waldron K (2005) Fractionation and characterisation of arabinoxylans from brewers’ spent grain and wheat bran. J Cereal Sci 42: 205–212.

    Article  CAS  Google Scholar 

  • Mares DJ, Stone BA (1973) Studies on wheat endosperm. I. Chemical composition and ultrastructure of the cell walls. Aust J Biol Sci 26: 793–812.

    Article  CAS  Google Scholar 

  • Masisi K, Diehl-Jones, Gordon J, Chapman D, Moghadasian M, Beta T (2015) Carotenoids of aleurone, germ and endosperm fractions of barley, corn and wheat differentially inhibit oxydative stress. J Agric Food Chem 63, 2715–2724.

    Article  CAS  PubMed  Google Scholar 

  • Matthews JM, Sunde M (2002) Zinc Fingers - Folds for Many Occasions. Life 54: 351–355.

    CAS  PubMed  Google Scholar 

  • Mellado-Ortega E, Hornero-Méndez D (2016) Carotenoid evolution during short storage period of durum wheat (Triticum turgidum conv. durum) and tritordeum (⨯ Tritordeum Ascherson et Graebner) whole-grain flours. Food Chem 192: 714–723.

    Article  CAS  PubMed  Google Scholar 

  • Mendis M, Leclerc E, Simsek S (2016) Arabinoxylans, gut microbiota and immunity. Carbohydrate Polymers 139: 159–166.

    Article  CAS  PubMed  Google Scholar 

  • Monge L, Cortassa G, Fiocchi F, Mussino G, Carta Q (1990) Glyco-insulinaemic response, digestion and intestinal absorption of the starch contained in two types of spaghetti. Diabetes, Nutrition and Metabolism 3: 239–246.

    Google Scholar 

  • Moore J, Cheng Z, Hao J, Guo G, Liu J-G, Lin C, Yu L (2007) Effects of solid-state yeast treatment on the antioxidant properties and protein and fiber compositions of common hard wheat bran. J Agric Food Chem 55: 10173–10182.

    Article  CAS  PubMed  Google Scholar 

  • Moore KL, Zhao F-J, Gritsch CS, Tosi P, Hawkesford MJ, McGrath SP et al. (2012) Localisation of iron in wheat grain using high resolution secondary ion mass spectrometry J Cereal Sci 55: 183–187.

    Article  CAS  Google Scholar 

  • Muir AD, Westcott ND (2000) Quantitation of the lignan secoisolariciresinol diglucoside in baked goods containing flax seed or flax meal. J Agric Food Chem 48: 4048–4052.

    Article  CAS  PubMed  Google Scholar 

  • Muraoka S, Miura T (2004) Inhibition of xanthine oxidase by phytic acid and its antioxidative action. Life Sci 74: 1691–1700.

    Article  CAS  PubMed  Google Scholar 

  • Nelson K, Mathai ML, Ashton JF, Donkor ON, Vasiljevic T, Mamilla R, Stojanovska L (2016) Effects of malted and non-malted whole-grain wheat on metabolic and inflammatory biomarkers in overweight/obese adults: a randomised crossover pilot study. Food Chem 194: 495–502.

    Article  CAS  PubMed  Google Scholar 

  • Ndolo VU, Beta T (2013) Distribution of carotenoids in endosperm, germ and aleurone fractions of cereal grain kernels. Food Chem 139, 663–671.

    Article  CAS  PubMed  Google Scholar 

  • Ndolo VU, Fulcher RG, Beta T (2015) Application of LC-MS-MS to identify niacin in aleurone layers of yellow corn, barley and wheat kernels. J Cereal Sci 65: 88–95.

    Article  CAS  Google Scholar 

  • Nemeth C, Freeman J, Jones HD, Sparks C, Pellny TK, Wilkinson MD et al. (2010) Downregulation of the CSLF6 gene results in decreased (1,3,1,4)-b-D-glucan in endosperm of wheat. Plant Physiol 152: 1209–1218.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nicolas J, Drapron R (1983) Lipoxygenase and some related enzymes in breadmaking. In: Barnes P J (ed) Lipids in Cereal Technology. Academic, London, p 213–235.

    Chapter  Google Scholar 

  • Nielsen MM, Hansen Å (2008) Stability of Vitamin E in Wheat Flour and Whole Wheat Flour During Storage. Cereal Chemistry 85: 716–720.

    Article  CAS  Google Scholar 

  • Nurit E, Lyan B, Pujos-Guillot E, Branlard G, Piquet A (2016) Change in B and E vitamin and lutein, b-sitosterol contents in industrial milling fractions and during toasted bread production. J Cereal Sci 69: 290–296.

    Article  CAS  Google Scholar 

  • Nurmi T, Lampi A-M, Nyström L, Turunen M., Piironen V (2010a) Effects of environment and genotype on phytosterols in wheat in the HEALTHGRAIN diversity screen. J Agric Food Chem 58: 9314–9323.

    Article  CAS  PubMed  Google Scholar 

  • Nurmi T, Lampi A-M, Nyström L, Turunen M, Piironen V (2010b) Effects of genotype and environment on steryl ferulates in wheat and rye in the HEALTHGRAIN diversity screen. J Agric Food Chem 58: 9332–9340.

    Article  CAS  PubMed  Google Scholar 

  • Nurmi T, Lampi A-M, Nyström L, Hemery Y, Rouau X, Piironen V (2012) Distribution and composition of phytosterols and steryl ferulate in wheat grain and bran fractions. Cereal Sci 56: 379–388.

    Article  CAS  Google Scholar 

  • Nyström L, Lampi A-M, Rita H, Aura A-M, Oksman-Caldentey K-M, Piiroen V (2007a) Effects of Processing on Availability of Total Plant Sterols, Steryl Ferulates and Steryl Glycosides from Wheat and Rye Bran. J Agric Food Chem 55: 9059–9065.

    Article  CAS  PubMed  Google Scholar 

  • Nyström L, Paasonen A, Lampi AM, Piironen V (2007b) Total plant sterols, steryl ferulates and steryl glycosides in milling fractions of wheat and rye. J Cereal Sci 45: 106–115.

    Article  CAS  Google Scholar 

  • O’Dell BL, de Boland AR, Koirtyohann SR (1972) Distribution of phytate and nutritionally important elements among the morphological components of cereal grains. J Agr Food Chem 20: 718–721.

    Article  Google Scholar 

  • Oury F-X, .Leenhardt F, Rémésy C, Chanliaud E, Duperrier B, Balfourier F, Charmet G (2006) Genetic variability and stability of grain magnesium, zinc and iron concentrations in bread wheat European J of Agronomy 25: 277–185.

    Article  CAS  Google Scholar 

  • Parker ML, Ng A, Waldron KW (2005) The phenolic acid and polysaccharide composition of cell walls of bran layers of mature wheat (Triticum aestivum L. cv. Avalon) grains. J Sci Food Agric 85: 2539–2547.

    Article  CAS  Google Scholar 

  • Panfili G, Fratianni A, Irano M (2004) Improved normal phase high liquid chromatography procedure for determination of carotenoids in cereals. J Agric Food Chem 52: 6373–6377.

    Article  CAS  PubMed  Google Scholar 

  • Panyoo AE, Emmambux MN (2017) Amylose–lipid complex production and potential health benefits: A mini-review. Starch/Stärke 69: 1600203.

    Article  CAS  Google Scholar 

  • Parveen S, Siyal AN, Memon N, Memon SQ, Khuhawar MY (2015) Extraction and determination of phenolic acids and vitamin B of sieved and unsieved wheat grain by MEKC. J Liquid Chrom Related Technol 38: 143–152.

    Article  CAS  Google Scholar 

  • Paznocht L, Kotíková Z, Šulc M, Lachman J, Orsák M, Eliášová M, Martinek P (2018) Free and esterified carotenoids in pigmented wheat, tritordeum and barley grains. Food Chem 240: 670–678.

    Article  CAS  PubMed  Google Scholar 

  • Pedersen HA, Laursen B, Mortensen A, Fomsgaard IS (2011) Bread from common cereal cultivars contains an important array of neglected bioactive benzoxazinoids. Food Chem 127: 1814–1820.

    Article  CAS  Google Scholar 

  • Persson DP, de Bang TC, Pedas PR, Kutman UB, Cakmak I, Andersen B et al. (2016) Molecular speciation and tissue compartmentation of zinc in durum wheat grains with contrasting nutritional status. New Phytologist 211: 1255–1265.

    Article  CAS  PubMed  Google Scholar 

  • Piironen V, Edelmann M, Kariluoto S, Bedo Z (2008) Folate in wheat genotypes in the HEALTHGRAIN diversity screen. J Agric Food Chem 56: 9726–9731.

    Article  CAS  PubMed  Google Scholar 

  • Piironen V, Syväoja E-L, Varo P, Salminen K, Koivistoinen P (1986) Tocopherols and tocotrienols in cereal products from Finland. Cereal Chem 63: 78–81.

    CAS  Google Scholar 

  • Pomeranz Y (1988) Chemical compounds of kernel structures. In: Pomeranz Y (ed) Wheat chemistry and technology. American Association of Cereal Chemists Inc., St. Paul., Minnesota, USA, pp. 97–158.

    Google Scholar 

  • Posner ES, Khan K, Shewry PR (2009) Wheat flour milling. In: Kahn K, Shewry PR (eds). Wheat: chemistry and technology, 4th ed. AACC International, Minneapolis, MN, USA, p 119–152.

    Chapter  Google Scholar 

  • Price RK, Keaveney EM, Hamill LL et al. (2010) Consumption of wheat aleurone-rich foods increases fasting plasma betaine and modestly fasting homocysteine and LDL-cholesterol in adults. J Nutr 140: 2153–2157.

    Article  CAS  PubMed  Google Scholar 

  • Price RK, Wallace JMW, Hamill LL, Wallace J M W., Ward M, Ueland P M et al. (2012) Evaluation of the effect of wheat aleurone-rich foods on markers of antioxidant status, inflammation and endothelial function in apparently healthy men and women. British J Nutr 108: 1644–1651.

    Article  CAS  Google Scholar 

  • Rashid S, Rakha A, Anjum FM, Ahmed W, Sohail M (2015) Effects of extrusion cooking on the dietary fibre content and Water Solubility Index of wheat bran extrudates International Journal of Food Science and Technology 50: 1533–1537.

    Article  CAS  Google Scholar 

  • Rios G, Pinson-Gadais L, Abecassis J, Zakhia-Rozis N, Lullien-Pellerin V (2009) Assessment of dehulling efficiency to reduce deoxynivalenol and fusarium level in durum wheat grains. J Cereal Sci 49: 387–392.

    Article  CAS  Google Scholar 

  • Rejman J, Kozubek A (2004) Inhibitory effect of natural phenolic lipids upon NAD-dependent deshydrogenases and on Triglyceride Accumulation in 3T3-L1 cells in culture. J Agric Food Chem 52: 246–250.

    Article  CAS  PubMed  Google Scholar 

  • Rhodes DI, Stone BA (2002) Proteins in walls of wheat aleurone cells. J Cereal Sci 36: 83–101.

    Article  CAS  Google Scholar 

  • Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE et al. (2005) Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther 314: 1079–1086.

    Article  CAS  PubMed  Google Scholar 

  • Ritsema T, Smeekens S (2003) Fructans: Beneficial for Plants and Humans. Current Opinion in Plant Biology 6: 223–230.

    Article  CAS  PubMed  Google Scholar 

  • Roberfroid MB (2005) Introducing inulin-type fructans. British J Nutr 93: 513–525.

    Article  CAS  Google Scholar 

  • Rodriguez-Ramiro I, Brearley CA, Bruggraber S F A, Perfecto A, Shewry P R, Fairweather-Tait S (2017) Assessment of iron bioavailability from different breadmaking processes using an in vitro intestinal cell model. Food Chem 228: 91–98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roohani N, Hurrell R, Kelishadi R Shulin R (2013) Zinc and its importance for human health: An integrative review Res Med Sci 18: 144–157.

    Google Scholar 

  • Rosa NN, Barron C, Gaiani C, Dufour C, Micard V (2013) Ultra-fine grinding increases the antioxidant capacity of wheat bran. J Cereal Sci 57: 84–90.

    Article  CAS  Google Scholar 

  • Ross AB, Shepherd MJ, Schüpphaus M, Sinclair V, Alfaro B, Kamal-Eldin A, Aman P (2003) Alkylresorcinols in cereals and cereal products. J Food Agric Chem 51: 4111–4118.

    Article  CAS  Google Scholar 

  • Ross A B, Zangger A, Guiraud SP (2014) Cereal foods are the major source of betaine in the Western diet – Analysis of betaine and free choline in cereal foods and updated assessments of betaine intake. Food Chem 145: 859–865.

    Article  CAS  PubMed  Google Scholar 

  • Rouau X, El-Hayek ML, Moreau D (1994). Effect of an enzyme preparation containing pentosanases on the bread-making quality of flours in relation to changes in pentosan properties. J Cereal Sci 19: 259–272.

    Article  CAS  Google Scholar 

  • Ryan AS (1997) Iron deficiency anemia in infant development: Implications for growth, cognitive development, resistance to infection, and iron supplementation Am J Phys Anthropol 104: 25–62.

    Article  Google Scholar 

  • Sandberg AS, Brune M, Carlsson NG, Hallberg L, Skoglund E, Rossander-Hulthén L (1999) Inositol phosphates with different numbers of phosphate groups influence iron absorption in humans. Am J Clin Nutr 70: 240–246.

    Article  CAS  PubMed  Google Scholar 

  • Saulnier L, Robert P, Grintchenko M, Jamme F, Bouchet B, Guillon F (2009) Wheat endosperm cell walls: Spatial heterogeneity of polysaccharide structure and composition using micro-scale enzymatic fingerprinting and FT-IR microspectroscopy. J Cereal Sci 50: 312–317.

    Article  CAS  Google Scholar 

  • Scazzina F, Del Rio D, Pellegrini N, Brighenti F (2009) Sourdough bread: Starch digestibility and postprandial glycemic response J Cereal Sci 49: 419–421.

    Article  CAS  Google Scholar 

  • Shewry PR, Hey SJ (2015) The contribution of wheat to human diet and health. Food and Energy Security 4: 178–202.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shewry PR, VanSchaik F, Ravel C, Charmet G, Rakszegi M, Bedo Z, Ward J L (2011) Genotype and environment effects on the contents of vitamins B1, B2, B3, and B6 in wheat grain. J Agric Food Chem 59: 10564–10571.

    Article  CAS  PubMed  Google Scholar 

  • Silva EO, Bracarense AP FRL (2016) Phytic acid: From antinutritional to multiple protection factor of organic systems. J Food Sci 81, 1357–1362.

    Article  CAS  Google Scholar 

  • Singh S, Gamlath S, Wakeling L (2007) Nutritional aspects of food extrusion: A review. Int J Food Sci Technol 42: 916–929.

    Article  CAS  Google Scholar 

  • Skodje GI, Sarna VK, Minelle I H, Rolfsen, K L, Muir J G, Gibson P R et al. (2018) Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity. Gastroenterology 154: 529–539.

    Article  CAS  PubMed  Google Scholar 

  • Slover HT, Lehmann J (1972) Effects of fumigation on wheat in storage. IV. Tocopherols. Cereal Chem. 49: 412–415.

    CAS  Google Scholar 

  • Smeds AI, Eklund PC, Sjoholm RE, Willför SM, Nishibe S, Deyama T, Holmbom BR (2007) Quantification of a Broad Spectrum of Lignans in Cereals Oilseeds, and Nuts. J Agric Food Chem 55: 1337–1346.

    Article  CAS  PubMed  Google Scholar 

  • Smeds AI, Jauhiainen L, Tuomola E, Peltonen-Sainio P (2009) Characterization of Variation in the Lignan Content and Composition of Winter Rye, Spring Wheat, and Spring Oat. J Agric Food Chem 57: 5837–5842.

    Article  CAS  PubMed  Google Scholar 

  • Spilioti E, Holmbom B, Papavassiliou AG, Moutsatsou P (2014) Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells. Mol Nutr Food Res 58: 749–759.

    Article  CAS  PubMed  Google Scholar 

  • Stone B, Morell MK (2009) Carbohydrates. In: Khan, K., Shewry, P.R. (Eds.), Wheat: Chemistry and Technology, 4th ed. American Association of Cereal Chemists, St Paul, MN, pp. 299–362.

    Chapter  Google Scholar 

  • Symons SJ, Dexter JE (1991) Computer analysis of fluorescence for the measurement of flour refinement as determined by flour ash content, flour grade color, and tristimulus color measurements. Cereal Chem 68: 454–460.

    Google Scholar 

  • Tanwir F, Fredholm M, Gregersen PL, Fomsgaards IS (2013) Comparison of the levels of bioactive benzoxazinoids in different wheat and rye fractions and the transformation of these compounds in homemade foods. Food Chem. 141: 444–450.

    Article  CAS  PubMed  Google Scholar 

  • Tekin M, Cengiz MF, Abbasov M, Aksoy A, Canci H, Akar T (2018) Comparison of some mineral nutrients and vitamins in advanced hulled wheat lines. Cereal Chem 95: 436–444.

    Article  CAS  Google Scholar 

  • Theuwissen E, Mensink RP (2008) Water-soluble dietary fibers and cardiovascular disease. Physiology and Behavior 94: 285–92.

    Article  CAS  PubMed  Google Scholar 

  • Tiwari BK (2015) Ultrasound: A clean, green extraction technology. Trends Anal Chem 71: 100–109.

    Article  CAS  Google Scholar 

  • Tiwari U, Cummins E (2009) Nutritional importance and effect of processing on tocols in cereals. Trends Food Sci Technol 20: 511–520.

    Article  CAS  Google Scholar 

  • Tluscik F, Kozubek A, Mejbaum-Katzenellenbogen W (1981) Alkylresorcinols in rye (Secale-Cereale L) grains. 6. Colorimetric micromethod for the determination of alkylresorcinols with the use of diazonium salt, fast blue-B. Acta Societatis Botanicorum Poloniae 50: 645–651.

    Article  CAS  Google Scholar 

  • Toole GA, Le Gall G, Colquhoun IJ, Nemeth C, Saulnier L, Lovegrove A et al. (2010) Temporal and spatial changes in cell wall composition in developing grains of wheat cv. Hereward. Planta 232: 677–689.

    Article  CAS  PubMed  Google Scholar 

  • Topping D (2007) Cereal complex carbohydrates and their contribution to human health. J Cereal Sci 46: 220–229.

    Article  CAS  Google Scholar 

  • Topping DL, Bajka BH, Bird AR, Clarke JM, Cobiac L, Conlon MA, Morell MK, Toden S (2008) Resistant starches as a vehicle for delivering health benefits to the human large bowel. Microbial Ecology in Health and Disease 20: 103–108.

    Article  CAS  Google Scholar 

  • Topping DL, Clifton PM (2001) Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 81: 1031–64.

    Article  CAS  PubMed  Google Scholar 

  • Van den Berg H, Faulks R, Granado HF, Hirschberg J, Olmedilla B, Sandmann G, Southon S, Stahl W (2000) The potential for the improvement of carotenoid levels in foods and the likely systemic effects. J Sci Food Agric 80: 880–912.

    Article  Google Scholar 

  • Varga M, Banhidi J, Cseuz L, Matuz J (2013) The anthocyanin content of blue and purple coloured wheat cultivars and their hybrid generations. Cereal Res Commun 41: 284–292.

    Article  CAS  Google Scholar 

  • Vitaglione P, Napolitano A, Fogliano V (2008) Cereal dietary fibre: A natural functional ingredient to deliver phenolic compounds into the gut. Trends Food Sci. Technol 19: 451–463.

    Article  CAS  Google Scholar 

  • Wang W-M, Klopfenstein CF, Ponte JG Jr (1993) Effects of Twin-Screw Extrusion on the Physical Properties of Dietary Fiber and Other Components of Whole Wheat and Wheat Bran and on the Baking Quality of the Wheat Bran. Cereal Chem 70: 707–711.

    Google Scholar 

  • Wang L, Weller CL (2006) Recent advances in extraction of nutraceuticals from plants. Trends Food Sci Technol 17: 300–312.

    Article  CAS  Google Scholar 

  • Wang H, Zhou Y, Ma J, Zhou Y, Jiang H (2013) The effects of phytic acid on the Maillard reaction and the formation of acrylamide. Food Chem 141: 18–22.

    Article  CAS  PubMed  Google Scholar 

  • Wennermark BH, Jagerstad M (1992) Breadmaking and Storage of Various Wheat Fractions Affect Vitamin E. Journal of Food Science 57: 1205–1209.

    Article  CAS  Google Scholar 

  • Werner S, Böhm V (2011) Bioaccessibility of carotenoids and Vitamin E from pasta: evaluation of an in vitro digestion model. J Agric Food Chem 59: 1163–1170.

    Article  CAS  PubMed  Google Scholar 

  • Witten S, Aulrich K (2018) Effect of variety and environment on the amount of thiamine and riboflavin in cereals and grain legumes. Anim Feed Sci Technol 238: 39–46.

    Article  CAS  Google Scholar 

  • Wolever TMS, Jenkins DJA, Kalmusky J, Giordano C, Giudici S, Jenkins AL et al. (1986) Glycemic response to pasta: effect of surface area, degree of cooking, and protein enrichment. Diabetes Care 9: 401–404.

    Article  CAS  PubMed  Google Scholar 

  • Yu L, Beta T (2015) Phenolic Compounds during Production of Bread from Purple Wheat Grains. Molecules 20: 15525–15549.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zandomeneghi M, Festa C, Carbonaro L (2000) Front-surface absorbance spectra of wheat flour: determination of carotenoids. J Agric Food Chem 48: 2216–2221.

    Article  CAS  PubMed  Google Scholar 

  • Zhang M, Bai X, Zhang Z (2011) Extrusion process improves the functionality of soluble dietary fiber in oat bran. J. Cereal Sci. 54: 98–103.

    Article  CAS  Google Scholar 

  • Zhu KX, Huang S, Peng W, Qian H F, Zhou H M (2010) Effect of ultrafine grinding on hydration and antioxidant properties of wheat bran dietary fiber. Food Res Int 43: 943–948.

    Article  CAS  Google Scholar 

  • Zhu Y, Soroka DN, Sang S (2012) Synthesis and Inhibitory Activities against Colon Cancer Cell Growth and Proteasome of Alkylresorcinols. J Agric Food Chem 60: 8624–8631.

    Article  CAS  PubMed  Google Scholar 

  • Zhu Y, Wang P, Sha W, Sang S (2016) Urinary Biomarkers of WholeGrain Wheat Intake Identifiedby Non-targeted and Targeted Metabolomics Approaches. Sci Reports 6: 36278.

    Article  CAS  Google Scholar 

  • Ziegler JU, Wahl S, Würschum T, Longin CF, Carle R, Schweiggert RM (2015) Lutein and lutein esters in whole grain flours made from 75 genotypes of 5 Triticum species grown at multiple sites. J Agric Food Chem 63: 5061–5071.

    Article  CAS  PubMed  Google Scholar 

  • Zielinski H, Kozlowska H, Lewczuk B (2001) Bioactive compounds in the cereal grains before and after hydrothermal processing. Innovative Food Science& Emerging Technologies 2: 159–169

    Article  CAS  Google Scholar 

  • Zile MH (1998) Vitamin A and embryonic development: an overview. J Nutr 128: 455S–458S.

    Article  CAS  PubMed  Google Scholar 

  • Zimmermann M B, Hurrell R F (2007) Nutritional iron deficiency. The Lancet 370: 511–520.

    Article  CAS  Google Scholar 

  • Zuo H, Svingen GFT, Tell GS, Ueland PM (2018) Plasma Concentrations and Dietary Intakes of Choline and Betaine in Association With Atrial Fibrillation Risk: Results From 3 Prospective Cohorts With Different Health Profiles. J Am Heart Assoc 7: e008190.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Paola Tosi or Valerie Lullien-Pellerin .

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Tosi, P., Hidalgo, A., Lullien-Pellerin, V. (2020). The Impact of Processing on Potentially Beneficial Wheat Grain Components for Human Health. In: Igrejas, G., Ikeda, T., Guzmán, C. (eds) Wheat Quality For Improving Processing And Human Health. Springer, Cham. https://doi.org/10.1007/978-3-030-34163-3_17

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