Heterogeneity in Clinical Research: Mechanisms Responsible (20 Studies)
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In clinical research similar studies often have different results. This may be due to differences in patient-characteristics and trial-quality-characteristics such as the use of blinding, randomization, and placebo-controls. This chapter is to assess whether 3-dimensional scatter plots and regression analyses with the treatment results as outcome and the predictors of heterogeneity as exposure are able to identify mechanisms responsible.