Heterogeneity in Clinical Research: Mechanisms Responsible (20 Studies)



In clinical research similar studies often have different results. This may be due to differences in patient-characteristics and trial-quality-characteristics such as the use of blinding, randomization, and placebo-controls. This chapter is to assess whether 3-dimensional scatter plots and regression analyses with the treatment results as outcome and the predictors of heterogeneity as exposure are able to identify mechanisms responsible.

Supplementary material

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heterogeneity (CSV 343 bytes)
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heterogeneity (SAV 1 kb)

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department Medicine Albert Schweitzer HospitalDordrechtThe Netherlands
  2. 2.Academic Medical CenterDepartment Biostatistics and EpidemiologyAmsterdamThe Netherlands

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