Advertisement

Heterogeneity in Clinical Research: Mechanisms Responsible (20 Studies)

Chapter
  • 968 Downloads

Abstract

In clinical research similar studies often have different results. This may be due to differences in patient-characteristics and trial-quality-characteristics such as the use of blinding, randomization, and placebo-controls. This chapter is to assess whether 3-dimensional scatter plots and regression analyses with the treatment results as outcome and the predictors of heterogeneity as exposure are able to identify mechanisms responsible.

Supplementary material

333106_2_En_41_MOESM1_ESM.csv (0 kb)
heterogeneity (CSV 343 bytes)
333106_2_En_41_MOESM2_ESM.sav (1 kb)
heterogeneity (SAV 1 kb)

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department Medicine Albert Schweitzer HospitalDordrechtThe Netherlands
  2. 2.Academic Medical CenterDepartment Biostatistics and EpidemiologyAmsterdamThe Netherlands

Personalised recommendations