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Nanomaterials and Neutrophils

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Interaction of Nanomaterials with the Immune System

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

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Abstract

Neutrophils are key components of the innate arm of the immune system and represent the front line of host defence against intruding pathogens. However, neutrophils can also cause damage to the host. Understanding nanomaterial interactions with neutrophils is of critical importance. In this chapter, we discuss how nanomaterials may recruit or activate neutrophils and how neutrophils, in turn, may target and digest certain types of nanomaterials. We also reflect on lessons learned from previous studies of host responses towards implantable biomaterials.

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Acknowledgements

Supported by the European Commission’s H2020 programme through BIORIMA (grant agreement no. 760928) and the Graphene Flagship (grant agreement no. 785219), and the Swedish Research Council, and Swedish Research Council for Health, Working Life and Welfare.

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Authors and Affiliations

  1. Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Sandeep Keshavan & Bengt Fadeel

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  1. Sandeep Keshavan
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  2. Bengt Fadeel
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Correspondence to Bengt Fadeel .

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Editors and Affiliations

  1. Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA

    James C. Bonner

  2. Department of Pharmaceutical Sciences Skaggs School of Pharmacy, University of Colorado, Aurora, CO, USA

    Jared M. Brown

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Keshavan, S., Fadeel, B. (2020). Nanomaterials and Neutrophils. In: Bonner, J., Brown, J. (eds) Interaction of Nanomaterials with the Immune System. Molecular and Integrative Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-030-33962-3_3

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