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Pathophysiology and Epidemiology of Osteoporosis

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Vertebral Compression Fractures in Osteoporotic and Pathologic Bone

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Abstract

Osteoporosis is the most common disease of the bone affecting greater than 10.2 million adults in the USA. This disease is a deficiency in the normal quantity of bone in the body and is defined as a bone mineral density < 2.5 standard deviations below the mean in young healthy individuals. On a cellular level, there are several interconnecting pathways that result in increased absorption of bone. These pathways are affected by genetics, medications, and lifestyle factors. Understanding the epidemiology and pathophysiology of osteoporosis can improve the surgeon’s ability to care for this growing patient population.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, NYU Langone Medical Center, New York, NY, USA

    Nicole M. Stevens & Sanjit R. Konda

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  1. Nicole M. Stevens
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  2. Sanjit R. Konda
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Correspondence to Sanjit R. Konda .

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Editors and Affiliations

  1. Vice Chair and Residency Program Director, Department of Orthopaedic Surgery, Maimonides Medical Center, Brooklyn, NY, USA

    Afshin E. Razi

  2. Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Stuart H. Hershman

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Stevens, N.M., Konda, S.R. (2020). Pathophysiology and Epidemiology of Osteoporosis. In: Razi, A., Hershman, S. (eds) Vertebral Compression Fractures in Osteoporotic and Pathologic Bone. Springer, Cham. https://doi.org/10.1007/978-3-030-33861-9_2

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  • DOI: https://doi.org/10.1007/978-3-030-33861-9_2

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