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Antimicrobial Resistance: A Challenge for the Future

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The First Outstanding 50 Years of “Università Politecnica delle Marche”

Abstract

The global emergence of antibiotic-resistance, together with the lack of/reduced development of new antibiotic molecules, currently represents a serious public health problem as it can mean the return to a pre-antibiotic era in which infections caused by multiple-resistant pathogens are intractable. Since the beginnings, the interest of the Institutes of Microbiology, Hygiene and Public Health, and Infectious Diseases was focused on antibiotic resistance: from molecular mechanisms, through epidemiology and clinical issues, to prevention. Future perspectives include the search of new strategies and/or new compounds for prevention and control of difficult-to-treat pathogens in a multidisciplinary approach.

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References

  1. Alfonsi V, Romano L, Ciccaglione AR et al (2018) Hepatitis E in Italy: 5 years of national epidemiological, virological and environmental surveillance, 2012 to 2016. Euro Surveill Bull Eur sur les Mal Transm Eur Commun Dis Bull 23. https://doi.org/10.2807/1560-7917.ES.2018.23.41.1700517

  2. Alvarez-Suarez JM, Morroni G, Brenciani A, Mingoia MFB (2018) Apis mellifera vs Melipona beecheti cuban polifloral honeys: a comparison based on their phytochemical parameters, chemical composition and biological properties. LWT-Food Sci Technol 87:272–279

    Article  Google Scholar 

  3. Antonelli A, D’Andrea MM, Brenciani A et al (2018) Characterization of poxtA, a novel phenicol-oxazolidinone-tetracycline resistance gene from an MRSA of clinical origin. J Antimicrob Chemother. https://doi.org/10.1093/jac/dky088

    Article  Google Scholar 

  4. Antonelli A, D’Andrea MM, Galano A et al (2016) Linezolid-resistant cfr-positive MRSA, Italy. J Antimicrob Chemother 71:2349–2351

    Article  Google Scholar 

  5. Bagnarelli P, Fiorelli L, Vecchi M et al (2003) Analysis of the functional relationship between V3 loop and gp120 context with regard to human immunodeficiency virus coreceptor usage using naturally selected sequences and different viral backbones. Virology 307:328–340

    Article  Google Scholar 

  6. Bagnarelli P, Marinelli K, Trotta D et al (2011) Human case of autochthonous West Nile virus lineage 2 infection in Italy, September 2011. Eurosurveillance. https://doi.org/10.1088/1742-6596/371/1/012054

    Article  Google Scholar 

  7. Bagnarelli P, Menzo S, Manzin A et al (1991) Detection of human immunodeficiency virus type 1 genomic RNA in plasma samples by reverse-transcription polymerase chain reaction. J Med Virol 34:89–95

    Article  Google Scholar 

  8. Bagnarelli P, Menzo S, Manzin A et al (1991) Detection of human immunodeficiency virus type 1 transcripts in peripheral blood lymphocytes by the polymerase chain reaction. J Virol Methods 32:31–39

    Article  Google Scholar 

  9. Bagnarelli P, Menzo S, Valenza A et al (2000) Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis. J Virol 71(9):6973–6981

    Google Scholar 

  10. Bagnarelli P, Menzo S, Valenza A et al (1995) Quantitative molecular monitoring of human immunodeficiency virus type 1 activity during therapy with specific antiretroviral compounds. J Clin Microbiol 33(1):16–23

    Google Scholar 

  11. Bagnarelli P, Valenza A, Menzo S et al (1994) Dynamics of molecular parameters of human immunodeficiency virus type 1 activity in vivo. J Virol 68(4):2495–2502

    Google Scholar 

  12. Balaban N, Gov Y, Giacometti A et al (2004) A chimeric peptide composed of a dermaseptin derivative and an RNA III-inhibiting peptide prevents graft-associated infections by antibiotic-resistant staphylococci. Antimicrob Agents Chemother 48:2544–2550. https://doi.org/10.1128/AAC.48.7.2544-2550.2004

    Article  Google Scholar 

  13. Baldassarri L, Creti R, Recchia S et al (2006) Therapeutic failures of antibiotics used to treat macrolide-susceptible Streptococcus pyogenes infections may be due to biofilm formation. J Clin Microbiol. https://doi.org/10.1128/JCM.00512-06

    Article  Google Scholar 

  14. Barbadoro P, Labricciosa FM, Recanatini C et al (2015) Catheter-associated urinary tract infection: Role of the setting of catheter insertion. Am J Infect Control. https://doi.org/10.1016/j.ajic.2015.02.011

    Article  Google Scholar 

  15. Barbadoro P, Marigliano A, D’Errico MM et al (2011) Gestational age as a single predictor of health care-associated bloodstream infections in neonatal intensive care unit patients. Am J Infect Control. https://doi.org/10.1016/j.ajic.2010.03.019

    Article  Google Scholar 

  16. Barbadoro P, Marigliano A, Savini S et al (2011) Group B Streptococcal sepsis: an old or ongoing threat? Am J Infect Control 39:e45–e48

    Google Scholar 

  17. Barbadoro P, Marmorale C, Recanatini C et al (2016) May the drain be a way in for microbes in surgical infections? Am J Infect Control. https://doi.org/10.1016/j.ajic.2015.10.012

    Article  Google Scholar 

  18. Barbadoro P, Martini E, Gioia MG et al (2017) Checking rounds for isolation precautions in the control of multidrug-resistant organisms: reduction achieved. Eur J Clin Microbiol Infect Dis. https://doi.org/10.1007/s10096-016-2896-1

    Article  Google Scholar 

  19. Barbadoro P, Martini E, Savini S et al (2014) Invivo comparative efficacy of three surgical hand preparation agents in reducing bacterial count. J Hosp Infect. https://doi.org/10.1016/j.jhin.2013.09.013

    Article  Google Scholar 

  20. Borghetti A, Baldin G, Capetti A et al (2017) Efficacy and tolerability of dolutegravir and two nucleos(t)ide reverse transcriptase inhibitors in HIV-1-positive, virologically suppressed patients. AIDS 31:457–459. https://doi.org/10.1097/QAD.0000000000001357

    Article  Google Scholar 

  21. Brenciani A, Bacciaglia A, Vignaroli C et al (2010) Phim46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes. Antimicrob Agents Chemother 54:221–229. https://doi.org/10.1128/AAC.00499-09

    Article  Google Scholar 

  22. Brenciani A, Fioriti S, Morroni G et al (2018) Detection in Italy of a porcine Enterococcus faecium isolate carrying the novel phenicol-oxazolidinone-tetracycline resistance gene poxtA. J Antimicrob Chemother. https://doi.org/10.1093/jac/dky505

    Article  Google Scholar 

  23. Brenciani A, Morroni G, Pollini S et al (2016) Characterization of novel conjugative multiresistance plasmids carrying CFR from linezolid-resistant Staphylococcus epidermidis clinical isolates from Italy. J Antimicrob Chemother 71:307–313. https://doi.org/10.1093/jac/dkv341

    Article  Google Scholar 

  24. Cirioni O, Giacometti A, Ghiselli R et al (2003) Prophylactic efficacy of topical temporin A and RNAIII-inhibiting peptide in a subcutaneous rat Pouch model of graft infection attributable to staphylococci with intermediate resistance to glycopeptides. Circulation 108:767–771. https://doi.org/10.1161/01.CIR.0000083717.85060.16

    Article  Google Scholar 

  25. Cirioni O, Giacometti A, Ghiselli R et al (2004) Potential therapeutic role of histatin derivative P-113d in experimental rat models of Pseudomonas aeruginosa sepsis. J Infect Dis 190:356–364. https://doi.org/10.1086/421913

    Article  Google Scholar 

  26. Cirioni O, Giacometti A, Ghiselli R et al (2005) Temporin A alone and in combination with imipenem reduces lethality in a mouse model of Staphylococcal sepsis. J Infect Dis 192:1613–1620. https://doi.org/10.1086/496888

    Article  Google Scholar 

  27. Cirioni O, Kamysz E, Ghiselli R et al (2011) Lipopeptide Laur-CKK-NH2 dimer preserves daptomycin susceptibility and enhances its activity against Enterococcus faecalis. J Antimicrob Chemother 66:859–862. https://doi.org/10.1093/jac/dkr001

    Article  Google Scholar 

  28. Cirioni O, Silvestri C, Ghiselli R et al (2009) Therapeutic efficacy of buforin II and rifampin in a rat model of Acinetobacter baumannii sepsis. Crit Care Med 37:1403–1407. https://doi.org/10.1097/CCM.0b013e31819c3e22

    Article  Google Scholar 

  29. Clementi M, Bagnarelli P, Pauri P, Calegari L (1984) Modulation of production of hepatitis B surface antigen by a human hepatoma cell line. J Med Virol 13:117–123

    Article  Google Scholar 

  30. Clementi M, Festa A, Testa I et al (1989) Expression of high- and low-affinity epidermal growth factor receptors in human hepatoma cell lines. FEBS Lett 249:297–301

    Article  Google Scholar 

  31. Clementi M, Testa I, Festa A et al (1987) Differential response of the human hepatoma-derived cell line HA22T/VGH to polypeptide mitogens. FEBS Lett 221:11–17

    Article  Google Scholar 

  32. Cochetti I, Tili E, Mingoia M et al (2008) erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.01457-07

    Article  Google Scholar 

  33. Cochetti I, Tili E, Vecchi M et al (2007) New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci. J Antimicrob Chemother. https://doi.org/10.1093/jac/dkm120

    Article  Google Scholar 

  34. Cochetti I, Vecchi M, Mingoia M et al (2005) Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I). Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.49.12.4999-5006.2005

    Article  Google Scholar 

  35. Coppa GV, Facinelli B, Magi G et al (2016) Human milk glycosaminoglycans inhibit in vitro the adhesion of Escherichia coli and Salmonella fyris to human intestinal cells. Pediatr Res. https://doi.org/10.1038/pr.2015.262

    Article  Google Scholar 

  36. Coppa GV, Zampini L, Galeazzi T et al (2006) Human milk oligosaccharides inhibit the adhesion to Caco-2 cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris. Pediatr Res. https://doi.org/10.1203/01.pdr.0000200805.45593.17

    Article  Google Scholar 

  37. Dentone C, Di Biagio A, Cozzi Lepri A et al (2018) Inflammatory effects of atazanavir/ritonavir versus darunavir/ritonavir in treatment naive, HIV-1-infected patients. HIV Clin Trials 19:158–162. https://doi.org/10.1080/15284336.2018.1488453

    Article  Google Scholar 

  38. Dini M, Fuà C, Renga G (1979) Enquiry on the antibiotic usage at Ancona Regional Hospital. Prog Clin Biol Res 35:59–61

    Google Scholar 

  39. Facinelli B, Giovanetti E, Casolari C, Varaldo PE (1994) Interactions with lectins and agglutination profiles of clinical, food, and environmental isolates of Listeria. J Clin Microbiol 32(12):2929–2935

    Google Scholar 

  40. Facinelli B, Giovanetti E, Magi G et al (1998) Lectin reactivity and virulence among strains of Listeria monocytogenes determined in vitro using the enterocyte-like cell line Caco-2. Microbiology. https://doi.org/10.1099/00221287-144-1-109

    Article  Google Scholar 

  41. Facinelli B, Giovanetti E, Varaldo PE et al (1991) Antibiotic resistance in foodborne listeria. Lancet

    Google Scholar 

  42. Facinelli B, Roberts MC, Giovanetti E et al (1993) Genetic basis of tetracycline resistance in food-borne isolates of Listeria innocua. Appl. Environ, Microbiol

    Book  Google Scholar 

  43. Facinelli B, Spinaci C, Magi G et al (2001) Association between erythromycin resistance and ability to enter human respiratory cells in group A streptococci. Lancet. https://doi.org/10.1016/S0140-6736(00)05253-3

    Article  Google Scholar 

  44. Facinelli B, Varaldo PE, Casolari C, Fabio U (1988) Cross-infection with Listeria monocytogenes confirmed by DNA fingerprinting. Lancet (London, England) 2:1247–1248

    Article  Google Scholar 

  45. Facinelli B, Varaldo PE, Toni M et al (1989) Ignorance about listeria. BMJ 299:738

    Article  Google Scholar 

  46. Garzetti GG, Ciavattini A, Goteri G et al (1994) Vaginal micropapillary lesions are not related to human papillomavirus infection: in situ hybridization and polymerase chain reaction detection techniques. Gynecol Obstet Invest 38:134–139. https://doi.org/10.1159/000292466

    Article  Google Scholar 

  47. Ghiselli R, Giacometti A, Cirioni O et al (2004) Cecropin B enhances betalactams activities in experimental rat models of gram-negative septic shock. Ann Surg 239:251–256. https://doi.org/10.1097/01.sla.0000108673.25385.03

    Article  Google Scholar 

  48. Ghiselli R, Giacometti A, Cirioni O et al (2006) RNAIII-inhibiting peptide in combination with the cathelicidin BMAP-28 reduces lethality in mouse models of staphylococcal sepsis. Shock 26:296–301. https://doi.org/10.1097/01.shk.0000226336.02292.86

    Article  Google Scholar 

  49. Ghiselli R, Giacometti A, Cirioni O et al (2008) Efficacy of the bovine antimicrobial peptide indolicidin combined with piperacillin/tazobactam in experimental rat models of polymicrobial peritonitis. Crit Care Med 36:240–245. https://doi.org/10.1097/01.CCM.0000292157.60632.89

    Article  Google Scholar 

  50. Giacometti A, Cirioni O, Ghiselli R et al (2004) Cathelicidin peptide sheep myeloid antimicrobial peptide-29 prevents endotoxin-induced mortality in rat models of septic shock. Am J Respir Crit Care Med 169:187–194. https://doi.org/10.1164/rccm.200307-971OC

    Article  Google Scholar 

  51. Giacometti A, Cirioni O, Ghiselli R et al (2004) The antimicrobial peptide BMAP-28 reduces lethality in mouse models of staphylococcal sepsis. Crit Care Med 32:2485–2490

    Article  Google Scholar 

  52. Giacometti A, Cirioni O, Ghiselli R et al (2006) Amphibian peptides prevent endotoxemia and bacterial translocation in bile duct-ligated rats. Crit Care Med 34:2415–2420. https://doi.org/10.1097/01.CCM.0000231879.11963.EB

    Article  Google Scholar 

  53. Giacometti A, Cirioni O, Kamysz W et al (2005) In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections. Antimicrob Agents Chemother 49:2507–2509. https://doi.org/10.1128/AAC.49.6.2507-2509.2005

    Article  Google Scholar 

  54. Giacometti A, Cirioni O, Schimizzi AM et al (2000) Epidemiology and microbiology of surgical wound infections. J Clin Microbiol 38(2):918–922

    Google Scholar 

  55. Giovanetti E, Brenciani A, Tiberi E et al (2012) ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements. Antimicrob Agents Chemother 56:591–594. https://doi.org/10.1128/AAC.05352-11

    Article  Google Scholar 

  56. Giovanetti E, Magi G, Brenciani A et al (2002) Conjugative transfer of the erm(A) gene from erythromycin-resistant Streptococcus pyogenes to macrolide-susceptible S. pyogenes, Enterococcus faecalis and Listeria innocua. J Antimicrob Chemother. https://doi.org/10.1093/jac/dkf122

  57. Giovanetti E, Montanari MP, Mingoia M, Varaldo PE (1999) Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains in Italy and heterogeneity of inducibly resistant strains. Antimicrob Agents Chemother. https://doi.org/10.1128/aac.01352-07

    Article  Google Scholar 

  58. Gristina G, Nardi G, Orazi D et al (2010) Prone positioning and intravenous zanamivir may represent effective alternatives for patients with severe ARDS virus A (H1N1) related pneumonia in hospitals with no access to ECMO. Crit Care Res Pract 2010:146456. https://doi.org/10.1155/2010/146456

    Article  Google Scholar 

  59. Kiran MD, Adikesavan NV, Cirioni O et al (2008) Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol 73:1578–1586. https://doi.org/10.1124/mol.107.044164

    Article  Google Scholar 

  60. Labricciosa FM, Sartelli M, Abbo LM et al (2018) Epidemiology and risk factors for isolation of multi-drug–resistant organisms in patients with complicated intra-abdominal infections. Surg Infect (Larchmt). https://doi.org/10.1089/sur.2017.217

    Article  Google Scholar 

  61. Magi G, Marini E, Facinelli B (2015) Antimicrobial activity of essential oils and carvacrol, and synergy of carvacrol and erythromycin, against clinical, erythromycin-resistant Group A Streptococci. Front Microbiol. https://doi.org/10.3389/fmicb.2015.00165

    Article  Google Scholar 

  62. Manzin A, Bagnarelli P, Menzo S et al (1994) Quantitation of hepatitis C virus genome molecules in plasma samples. J Clin Microbiol 32:1939–1944

    Google Scholar 

  63. Manzin A, Candela M, Paolucci S et al (1994) Presence of hepatitis C virus (HCV) genomic RNA and viral replicative intermediates in bone marrow and peripheral blood mononuclear cells from HCV-infected patients. Clin Diagn Lab Immunol 1:160–163

    Google Scholar 

  64. Manzin A, Menzo S, Bagnarelli P et al (1992) Sequence analysis of the hepatitis B virus pre-C region in hepatocellular carcinoma [HCC] and nontumoral liver tissues from HCC patients. Virology 188:890–895

    Article  Google Scholar 

  65. Manzin A, Palmieri C, Serra C et al (2008) Streptococcus suis meningitis without history of animal contact, Italy. Emerg Infect Dis 14(12):1946

    Google Scholar 

  66. Manzin A, Paolucci S, Lampertico P et al (1993) Direct detection of HBV preC mutants in heterogeneous viral populations by a modified DNA sequencing method. Res Virol 144:303–306

    Article  Google Scholar 

  67. Manzin A, Salvoni G, Bagnarelli P et al (1991) A single-step DNA extraction procedure for the detection of serum hepatitis B virus sequences by the polymerase chain reaction. J Virol Methods 32:245–253

    Article  Google Scholar 

  68. Marigliano A, Barbadoro P, Pennacchietti L et al (2012) Active training and surveillance: 2 good friends to reduce urinary catheterization rate. Am J Infect Control 40:692–695

    Article  Google Scholar 

  69. Marigliano A, D’Errico MM, Pellegrini I et al (2010) Ultrasound echocardiographic gel contamination by Burkholderia cepacia in an Italian hospital. J Hosp Infect. https://doi.org/10.1016/j.jhin.2010.07.017

    Article  Google Scholar 

  70. Marinelli K, Bagnarelli P, Gaffi G et al (2007) PCR real time assays for the early detection of BKV-DNA in immunocompromised patients. New Microbiol 30:275–278

    Google Scholar 

  71. Marini E, Di Giulio M, Magi G et al (2018) Curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of Mycobacterium abscessus. Phyther Res. https://doi.org/10.1002/ptr.5994

    Article  Google Scholar 

  72. Marini E, Magi G, Ferretti G et al (2018) Attenuation of Listeria monocytogenes virulence by Cannabis sativa L. Front Cell Infect Microbiol, Essential Oil. https://doi.org/10.3389/fcimb.2018.00293

    Book  Google Scholar 

  73. Marini E, Magi G, Mingoia M et al (2015) Antimicrobial and anti-virulence activity of capsaicin against erythromycin-resistant, cell-invasive group A streptococci. Front Microbiol. https://doi.org/10.3389/fmicb.2015.01281

    Article  Google Scholar 

  74. Marini E, Magi G, Vincenzi C et al (2016) Ongoing outbreak of invasive listeriosis due to serotype 1/2a Listeria monocytogenes, Ancona province, Italy, January 2015 to February 2016. Eurosurveillance. https://doi.org/10.2807/1560-7917.ES.2016.21.17.30217

    Article  Google Scholar 

  75. Mascaro V, Leonetti M, Nobile CGA et al (2018) Prevalence of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) among farm and slaughterhouse workers in Italy. J Occup Environ Med 60:e416–e425. https://doi.org/10.1097/JOM.0000000000001385

    Article  Google Scholar 

  76. Massimo A, Teti E, Antinori A et al (2017) Ombitasvir/paritaprevir/ritonavir and dasabuvir combination treatment in patients with HIV/HCV co-infection: results of an Italian compassionate use program. Clin Infect Dis 64:680–683. https://doi.org/10.1093/cid/ciw846

    Article  Google Scholar 

  77. Menzo S, Bagnarelli P, Giacca M et al (1992) Absolute quantitation of viremia in human immunodeficiency virus infection by competitive reverse transcription and polymerase chain reaction. J Clin Microbiol 30(7):1752–1757

    Google Scholar 

  78. Menzo S, Castagna A, Monachetti A et al (2004) Resistance and replicative capacity of HIV-1 strains selected in vivo by long-term enfuvirtide treatment. New Microbiol 27:51–61

    Google Scholar 

  79. Menzo S, Ciavattini A, Bagnarelli P et al (2008) Molecular epidemiology and pathogenic potential of underdiagnosed human papillomavirus types. BMC Microbiol 8:112. https://doi.org/10.1186/1471-2180-8-112

    Article  Google Scholar 

  80. Menzo S, Clementi M, Alfani E et al (1993) Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product. Virology 196:878–882. https://doi.org/10.1006/viro.1993.1550

    Article  Google Scholar 

  81. Menzo S, Manzin A, Bagnarelli P et al (1992) Lack of detectable human T-cell lymphotropic virus type I sequences in samples from multiple sclerosis patients. J Med Virol 36:155–161

    Article  Google Scholar 

  82. Menzo S, Minosse C, Vincenti D et al (2018) Long-term follow-up of acute hepatitis B: new insights in its natural history and implications for antiviral treatment. Genes (Basel). https://doi.org/10.3390/genes9060293

    Article  Google Scholar 

  83. Menzo S, Monachetti A, Trozzi C et al (2001) Identification of six putative novel human papillomaviruses (HPV) and characterization of candidate HPV type 87. J Virol 75:11913–11919. https://doi.org/10.1128/JVI.75.23.11913-11919.2001

    Article  Google Scholar 

  84. Menzo S, Sampaolesi R, Vicenzi E et al (1998) Rare mutations in a domain crucial for V3-loop structure prevail in replicating HIV from long-term non-progressors. AIDS 12:985–997

    Article  Google Scholar 

  85. Menzo S, Vincenti D, Solmone M et al (2009) Low-abundance drug resistance mutations: extending the HIV paradigm to hepatitis B virus. J Infect Dis 200:1798–1800

    Article  Google Scholar 

  86. Mingoia M, Morici E, Brenciani A et al (2015) Genetic basis of the association of resistance genes mef(I) (macrolides) and catQ (chloramphenicol) in streptococci. Front, Microbiol

    Book  Google Scholar 

  87. Mingoia M, Morici E, Marini E et al (2016) Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: characterization of ICESagTR7, a new composite element containing IMESp2907. J Antimicrob Chemother 71:593–600. https://doi.org/10.1093/jac/dkv408

    Article  Google Scholar 

  88. Mingoia M, Morici E, Morroni G et al (2014) Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.03638-14

    Article  Google Scholar 

  89. Mingoia M, Morici E, Tili E et al (2013) Characterization of Tn5801. Sag, a variant of staphylococcus aureus Tn916 family transposon Tn5801 that is widespread in clinical isolates of Streptococcus agalactiae. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00521-13

  90. Mingoia M, Tili E, Manso E et al (2011) Heterogeneity of Tn5253-like composite elements in clinical Streptococcus pneumoniae isolates. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.01087-10

    Article  Google Scholar 

  91. Mingoia M, Vecchi M, Cochetti I et al (2007) Composite structure of Streptococcus pneumoniae containing the erythromycin efflux resistance gene mef(I) and the chloramphenicol resistance gene catQ. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00790-07

    Article  Google Scholar 

  92. Montanari MP, Cochetti I, Mingoia M, Varaldo PE (2003) Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.47.7.2236-2241.2003

    Article  Google Scholar 

  93. Montanari MP, Mingoia M, Cochetti I, Varaldo PE (2003) Phenotypes and genotypes of erythromycin-resistant pneumococci in Italy. J Clin Microbiol 41:428–431

    Article  Google Scholar 

  94. Montanari MP, Mingoia M, Giovanetti E, Varaldo PE (2001) Differentiation of resistance phenotypes among erythromycin-resistant pneumococci. J Clin Microbiol. https://doi.org/10.1128/JCM.39.4.1311-1315.2001

    Article  Google Scholar 

  95. Morici E, Simoni S, Brenciani A et al (2017) A new mosaic integrative and conjugative element from Streptococcus agalactiae carrying resistance genes for chloramphenicol (catQ) and macrolides [mef(I) and erm(TR)]. J Antimicrob Chemother. https://doi.org/10.1093/jac/dkw367

    Article  Google Scholar 

  96. Morroni G, Alvarez-Suarez JM, Brenciani A et al (2018) Comparison of the antimicrobial activities of four honeys from three countries (New Zealand, Cuba, and Kenya). Front Microbiol. https://doi.org/10.3389/fmicb.2018.01378

    Article  Google Scholar 

  97. Morroni G, Brenciani A, Brescini L et al (2018) High rate of ceftobiprole resistance among clinical methicillin-resistant Staphylococcus aureus isolates from a Hospital in Central Italy. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.01663-18

    Article  Google Scholar 

  98. Palmieri C, Magi G, Mingoia M et al (2012) Characterization of a Streptococcus suis tet(O/W/32/O)-carrying element transferable to major streptococcal pathogens. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00629-12

    Article  Google Scholar 

  99. Palmieri C, Mingoia M, Massidda O et al (2012) Streptococcus pneumoniae transposon Tn1545/Tn6003 changes to Tn6002 due to spontaneous excision in circular form of the erm(B)- and aphA3-containing macrolide-aminoglycoside-streptothricin (MAS) element. Antimicrob Agents Chemother 56:5994–5997. https://doi.org/10.1128/AAC.01487-12

    Article  Google Scholar 

  100. Palmieri C, Mingoia M, Varaldo PE (2013) Unconventional circularizable bacterial genetic structures carrying antibiotic resistance determinants. Antimicrob Agents Chemother 57:2440–2441

    Article  Google Scholar 

  101. Palmieri C, Princivalli MS, Brenciani A et al (2011) Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00965-10

    Article  Google Scholar 

  102. Palmieri C, Varaldo PE, Facinelli B (2011) Streptococcus suis, an emerging drug-resistant animal and human pathogen. Front Microbiol 2:235

    Google Scholar 

  103. Pantaleo G, Menzo S, Vaccarezza M et al (1995) Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med. https://doi.org/10.1056/NEJM199501263320402

    Article  Google Scholar 

  104. Pierangeli A, Trotta D, Scagnolari C et al (2014) Rapid spread of the novel respiratory syncytial virus A ON1 genotype, central Italy, 2011 to 2013. Euro Surveill Bull Eur sur les Mal Transm Eur Commun Dis Bull 19:20843

    Google Scholar 

  105. Pierri MD, Crescenzi G, Capestro F et al (2016) Risk factors and impact on clinical outcome of multidrug-resistant acinetobacter baumannii acquisition in cardiac surgery patients. J Cardiothorac Vasc Anesth. https://doi.org/10.1053/j.jvca.2015.08.024

    Article  Google Scholar 

  106. Princivalli MS, Palmieri C, Magi G et al (2009) Genetic diversity of Streptococcus suis clinical isolates from pigs and humans in Italy (2003–2007). Euro Surveill Bull Eur sur les Mal Transm Eur Commun Dis Bull 14:19310

    Google Scholar 

  107. Princivalli MS, Paoletti C, Magi G et al (2009) Lactobacillus rhamnosus GG inhibits invasion of cultured human respiratory cells by prtF1-positive macrolide-resistant group A streptococci. Lett Appl Microbiol 48:368–372. https://doi.org/10.1111/j.1472-765X.2008.02540.x

    Article  Google Scholar 

  108. Prosperi MCF, Zazzi M, Punzi G et al (2010) Low rate of virological failure and maintenance of susceptibility to HIV-1 protease inhibitors with first-line lopinavir/ritonavir-based antiretroviral treatment in clinical practice. J Med Virol 82:1996–2003. https://doi.org/10.1002/jmv.21927

    Article  Google Scholar 

  109. Prospero E, Bacelli S, Barbadoro P et al (2008) Improvement of the ventilator associated pneumonia rate with infection control practices in an Italian ICU. Minerva Anestesiol 74:537–541

    Google Scholar 

  110. Prospero E, Barbadoro P, Annino I, D’Errico MM (2007) Surgical site infections: might a longer locally defined T time affect the benchmarking? Am J Infect Control 35:582–584

    Article  Google Scholar 

  111. Prospero E, Barbadoro P, Esposto E et al (2010) Extended-spectrum β-lactamases Klebsiella pneumoniae: multimodal infection control program in intensive care units. J Prev Med Hyg 51:110–115

    Google Scholar 

  112. Prospero E, Barbadoro P, Marigliano A et al (2011) Perioperative antibiotic prophylaxis: improved compliance and impact on infection rates. Epidemiol Infect 139:1326–1331

    Article  Google Scholar 

  113. Prospero E, Barbadoro P, Savini S et al (2006) Cluster of Pseudomonas aeruginosa catheter-related bloodstream infections traced to contaminated multidose heparinized saline solutions in a medical ward. Int J Hyg Environ Health 209:553–556

    Article  Google Scholar 

  114. Prospero E, Cavicchi A, Bacelli S et al (2006) Surveillance for surgical site infection after hospital discharge: a surgical procedure-specific perspective. Infect Control Hosp Epidemiol 27:1313–1317

    Article  Google Scholar 

  115. Prospero E, Illuminati D, Marigliano A et al (2012) Learning from Galileo: ventilator-associated pneumonia surveillance. Am J Respir Crit Care Med

    Google Scholar 

  116. Puzelli S, Facchini M, De Marco MA et al (2010) Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin mutations and clinical outcome. Euro Surveill Bull Eur sur les Mal Transm Eur Commun Dis Bull 15:19696

    Google Scholar 

  117. Sartelli M, Labricciosa FM, Barbadoro P et al (2017) The global alliance for infections in surgery: defining a model for antimicrobial stewardship-results from an international cross-sectional survey. World J Emerg Surg. https://doi.org/10.1186/s13017-017-0145-2

    Article  Google Scholar 

  118. Simonetti O, Arzeni D, Ganzetti G et al (2009) In vitro activity of the lipopeptide derivative (Pal-Lys-Lys-NH), alone and in combination with antifungal agents, against clinical isolates of dermatophytes. Br J Dermatol 161:249–252. https://doi.org/10.1111/j.1365-2133.2009.09166.x

    Article  Google Scholar 

  119. Simonetti O, Cirioni O, Orlando F et al (2011) Effectiveness of antimicrobial photodynamic therapy with a single treatment of RLP068/Cl in an experimental model of Staphylococcus aureus wound infection. Br J Dermatol 164:987–995. https://doi.org/10.1111/j.1365-2133.2011.10232.x

    Article  Google Scholar 

  120. Simonetti O, Lucarini G, Orlando F et al (2017) Role of daptomycin on burn wound healing in an animal methicillin-resistant Staphylococcus aureus infection model. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00606-17

    Article  Google Scholar 

  121. Simoni S, Vincenzi C, Brenciani A et al (2018) Molecular characterization of Italian isolates of fluoroquinolone-resistant Streptococcus agalactiae and relationships with chloramphenicol resistance. Microb Drug Resist 24:225–231. https://doi.org/10.1089/mdr.2017.0139

    Article  Google Scholar 

  122. Solmone M, Giombini E, Vincenti D et al (2014) Slow response to entecavir treatment in treatment-naive HBV patients is conditioned by immune response rather than by the presence or selection of refractory variants. Antivir Ther 19:201–209. https://doi.org/10.3851/IMP2700

    Article  Google Scholar 

  123. Spinaci C, Magi G, Varaldo PE, Facinelli B (2006) Persistence of erythromycin-resistant group A streptococci in cultured respiratory cells. Pediatr Infect Dis J. https://doi.org/10.1097/01.inf.0000238136.63851.4a

    Article  Google Scholar 

  124. Tarantino G, Bagnarelli P, Marzioni M et al (2016) Hepatitis E in a region of Italy: an emerging autochthonous infection? Dig Liver Dis 48:1340–1345. https://doi.org/10.1016/j.dld.2016.06.035

    Article  Google Scholar 

  125. Taus C, Pucci E, Cartechini E et al (2000) Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis. Acta Neurol Scand 101:224–228

    Article  Google Scholar 

  126. Valli MB, Meschi S, Selleri M et al (2010) Evolutionary pattern of pandemic influenza (H1N1) 2009 virus in the late phases of the 2009 pandemic. PLoS Curr 2:RRN1149

    Google Scholar 

  127. Valli MB, Selleri M, Meschi S et al (2011) Hemagglutinin 222 variants in pandemic (H1N1) 2009 virus. Emerg Infect Dis 17:749–751

    Article  Google Scholar 

  128. Varaldo PE, Montanari MP, Giovanetti E (2009) Genetic elements responsible for erythromycin resistance in streptococci. Antimicrob. Agents Chemother 53(2):343–353

    Google Scholar 

  129. Vecchi M, Burighel N, Bellanova D et al (2004) Immune reconstitution in HIV-1 infected children with discordant response to antiretroviral therapies: patterns of HIV-1 env gene evolution driven by restoration of thymic function. New Microbiol 27:99–104

    Google Scholar 

  130. Vincenti D, Piselli P, Solmone M et al (2017) Evolutionary trends of resistance mutational patterns of HBV reverse transcriptase over years (2002–2012) of different treatment regimens: the legacy of lamivudine/adefovir combination treatment. Antiviral Res 143:62–68. https://doi.org/10.1016/j.antiviral.2017.03.008

    Article  Google Scholar 

  131. Vincitorio D, Barbadoro P, Pennacchietti L et al (2014) Risk factors for catheter-associated urinary tract infection in Italian elderly. Am J Infect Control 42:898–901

    Article  Google Scholar 

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Authors and Affiliations

  1. Microbiology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy

    Pietro Emanuele Varaldo, Bruna Facinelli, Marina Mingoia & Andrea Brenciani

  2. Virology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy

    Patrizia Bagnarelli & Stefano Menzo

  3. Infectious Diseases Clinic, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy

    Andrea Giacometti, Francesco Barchiesi, Lucia Brescini, Oscar Cirioni & Giorgio Scalise

  4. Hygiene and Public Health Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy

    Pamela Barbadoro, Francesco Di Stanislao, Emilia Prospero & Marcello Mario D’Errico

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  1. Pietro Emanuele Varaldo
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  2. Bruna Facinelli
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  13. Francesco Di Stanislao
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  15. Marcello Mario D’Errico
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Corresponding authors

Correspondence to Stefano Menzo , Marina Mingoia , Andrea Brenciani , Andrea Giacometti or Pamela Barbadoro .

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Editors and Affiliations

  1. Department of Information Engineering (DII), Marche Polytechnic University, Ancona, Italy

    Sauro Longhi

  2. Department of Information Engineering (DII), Marche Polytechnic University, Ancona, Italy

    Andrea Monteriù

  3. Department of Information Engineering (DII), Marche Polytechnic University, Ancona, Italy

    Alessandro Freddi

  4. Department of Agricultural, Food and Environmental Sciences (D3A), Marche Polytechnic University, Ancona, Italy

    Lucia Aquilanti

  5. Ospedali Riuniti di Ancona, Ancona, Italy

    Maria Gabriella Ceravolo

  6. Department of Life and Environmental Sciences (DISVA), Marche Polytechnic University, Ancona, Italy

    Oliana Carnevali

  7. Department of Life and Environmental Sciences (DISVA), Marche Polytechnic University, Ancona, Italy

    Mario Giordano

  8. Ospedali Riuniti di Ancona, Ancona, Italy

    Gianluca Moroncini

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Varaldo, P.E. et al. (2020). Antimicrobial Resistance: A Challenge for the Future. In: Longhi, S., et al. The First Outstanding 50 Years of “Università Politecnica delle Marche”. Springer, Cham. https://doi.org/10.1007/978-3-030-33832-9_2

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