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The First Outstanding 50 Years of “Università Politecnica delle Marche” pp 203–219Cite as

Celiac Disease: A Journey Through Time and Space

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Abstract

Celiac disease (CD) is a multi-systemic autoimmune disorder induced by gluten exposure in genetically susceptible individuals. At the time we developed our interest on CD during the 1980s, this disorder was considered rare. Initially we started investigating the epidemiology of CD in Italy and other countries using new diagnostic tools, then moved on to other studies aimed to clarify the clinical picture of this condition and the dose-effect relationship between the ingestion of gluten and the celiac enteropathy. By showing that CD is much more common than previously thought, our pioneer works had a significant impact at the international level and were validated by further investigations conducted all over the world. Then our major research interest was to shed a light on the complex interplay between genetic and environmental factors leading to CD. We contributed to understand the role of early nutrition as a disease trigger, by means of long-term, prospective, intervention studies. The results of this recent work contributed to change the current recommendations on infant nutrition at the European level. Our current studies contributed to shift from the “Ptolemaic” view of a single disorder (CD) to the “Copernican” view of a system of different and interconnected gluten-related disorders.

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Author information

Authors and Affiliations

  1. Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, Via Tronto 10/a, 60020, Torrette, Ancona, Italy

    Carlo Catassi & Elena Lionetti

Authors
  1. Carlo Catassi
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  2. Elena Lionetti
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Corresponding author

Correspondence to Carlo Catassi .

Editor information

Editors and Affiliations

  1. Department of Information Engineering (DII), Marche Polytechnic University, Ancona, Italy

    Sauro Longhi

  2. Department of Information Engineering (DII), Marche Polytechnic University, Ancona, Italy

    Andrea Monteriù

  3. Department of Information Engineering (DII), Marche Polytechnic University, Ancona, Italy

    Alessandro Freddi

  4. Department of Agricultural, Food and Environmental Sciences (D3A), Marche Polytechnic University, Ancona, Italy

    Lucia Aquilanti

  5. Ospedali Riuniti di Ancona, Ancona, Italy

    Maria Gabriella Ceravolo

  6. Department of Life and Environmental Sciences (DISVA), Marche Polytechnic University, Ancona, Italy

    Oliana Carnevali

  7. Department of Life and Environmental Sciences (DISVA), Marche Polytechnic University, Ancona, Italy

    Mario Giordano

  8. Ospedali Riuniti di Ancona, Ancona, Italy

    Gianluca Moroncini

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Catassi, C., Lionetti, E. (2020). Celiac Disease: A Journey Through Time and Space. In: Longhi, S., et al. The First Outstanding 50 Years of “Università Politecnica delle Marche”. Springer, Cham. https://doi.org/10.1007/978-3-030-33832-9_15

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  • DOI: https://doi.org/10.1007/978-3-030-33832-9_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-33831-2

  • Online ISBN: 978-3-030-33832-9

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