Abstract
The impact of chronic training on pituitary function is best understood by a basic appraisal of the neuroendocrine physiology of any given individual axis and the more complex interactive pathophysiology among axes. Interaxes interactions have received relatively little attention. Even evaluating a single neuroendocrine axis in its dynamic state is a complicated challenge, given combined feedforward and feedback activities among the key control loci within any given axis. For example, in the case of the growth hormone (GH) and insulin-like growth factor 1 (IGF-1) axis, hypothalamic GH-releasing hormone (GHRH) secreted by arcuate nuclei stimulates pituitary GH secretion acutely, whereas the somatostatinergic system originating in the paraventricular nuclei opposes GHRH action. These two neuronal inputs are reciprocally interconnected by intrahypothalamic synapses and common impinging neuromodulator pathways. In addition, secreted GH feeds back on brain GH receptors, stimulating somatostatin secretion and possibly inhibiting GHRH release. Available GH secreted into the bloodstream triggers IGF-1 production in various target tissues, and circulating IGF-1 is capable of inhibiting pituitary GH secretion indirectly and directly. Such feedforward (GHRHs driving GH secretion) and feedback (GHs inhibiting its own secretion, IGF-1 s inhibiting GH secretion, and so forth) dynamic control mechanisms in principle can be modified by the effects of exercise at one or more levels within the axis. Moreover, multiple determinants modulate neuroendocrine responses to training, such as the body composition of the individual, concurrent stress and/or weight loss, gender, diet and energy balance, concomitant drug or hormone use, age, puberty, pregnancy, and/or lactational status.
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Veldhuis JD, Yoshida K, Iranmanesh A. The effect of mental and metabolic stress on the female reproductive system and female reproductive hormones. In: Hubbard J, Workman EA, editors. Handbook of stress medicine: an organ system approach. Boca Raton: CRC; 1997. p. 115–40.
Veldhuis JD, Evans WS, Weltman AL, Weltman JY, Rogol AD. Impact of exercise, as a paradigm of a physical stressor, on the female hypothalamo-pituitary-gonadal axis. In: Genazzani AR, Pertraglia F, editors. Hormones in gynecological endocrinology. UK: Parthenon Publishing; 1992. p. 337–49.
Luger A, Deuster PA, Gold PW, Loriaux DL, Chrousos GP. Hormonal responses to the stress of exercise. Adv Exp Med Biol. 1988;245:273–80.
Bullen BA, Skrinar GS, Beitins IZ, Carr DB, Reppert SM, Dotson CO, et al. Endurance training effects of plasma hormonal responsiveness and sex hormone excretion. J Appl Physiol. 1984;56:1453–63.
Roberts AC, McClure RD, Weiner RI, Brooks GA. Overtraining affects male reproductive status. Fertil Steril. 1993;60:686–92.
Crist DM, Hill JM. Diet and insulin-like growth factor I in relation to body composition in women with exercise-induced hypothalamic amenorrhea. J Am Coll Nutr. 1990;9:200–4.
Loucks AB. Effects of exercise training on the menstrual cycle: existence and mechanisms. Med Sci Sports Exerc. 1990;22:275–80.
Wittet GA, Livesey JH, Espiner EA, Donald RA. Adaptation of the hypothalamopituitary adrenal axis to chronic exercise stress in humans. Med Sci Sports Exerc. 1996;28:1015–9.
Viru A, Karelson K, Smirnova T. Stability and variability in hormonal responses to prolonged exercise. Int J Sports Med. 1992;13:230–5.
Dishman RK. Brain monoamines, exercise, and behavioral stress: animal models. Med Sci Sports Exerc. 1997;29:63–74.
Deuster PA, Chrousos GP, Luger A, DeBolt JE, Bernier LL, Trostmann UH, Kyle SB, Montgomery LC, Loriaux DL. Hormonal and metabolic responses of untrained, moderately trained, and highly trained men to three exercise intensities. Metabolism. 1989 Feb;38(2):141–8.
Rogol AD, Weltman JY, Evans WS, Veldhuis JD, Weltman AL. Long-term endurance training alters the hypothalamic-pituitary axes for gonadotropins and growth hormone. In: Veldhuis JD, editor. Endocrinology and metabolism clinics of North America. Philadelphia: WB Saunders; 1992. p. 817–32.
Veldhuis JD. Male hypothalamic-pituitary-gonadal axis. In: Yen SC, Jaffe RB, Barbieri RL, editors. Reproductive endocrinology. Philadelphia: WB Saunders; 1999. p. 622–31.
Straume M, Chen L, Johnson ML, Veldhuis JD. Systems-level analysis of physiological regulation interactions controlling complex secretory dynamics of growth hormone axis: a connectionist network model. Methods Neurosci. 1995;28:270–310.
Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of GH secretion in experimental animals and the human. Endocr Rev. 1998;19:717–97.
Clapp JF. The effects of maternal exercise on early pregnancy outcome. Am J Obstet Gynecol. 1989;161:1453–7.
Altemus M, Deuster PA, Galliven E, Carter CS, Gold PW. Suppression of hypothalamic–pituitary–adrenal axis responses to stress in lactating women. J Clin Endocrinol Metab. 1995;80:2954–9.
Bonen A, Campagna P, Gilchrist L, Young DC, Beresford P. Substrate and endocrine responses during exercise at selected stages of pregnancy. J Appl Physiol. 1992;73:134–42.
Veldhuis JD, Evans WS, Demers LM, Thorner MO, Wakat D, Rogol AD. Altered neuroendocrine regulation of gonadotropin secretion in women distance runners. J Clin Endocrinol Metab. 1985;61:557–63.
Weltman A, Weltman JY, Schurrer R, Evans WS, Veldhuis JD, Rogol AD. Endurance training amplifies the pulsatile release of growth hormone: effects of training intensity. J Appl Physiol. 1992;76(6):2188–96.
Rogol AD, Weltman A, Weltman JY, Seip RL, Snead DB, Levine S, et al. Durability of the reproductive axis in eumenorrheic women during one year of endurance training. J Appl Physiol. 1992;72(4):1571–80.
Snead DB, Weltman JY, Weltman A, Evans WS, Veldhuis JD, Varma MM, et al. Reproductive hormones and bone mineral density in women runners. J Appl Physiol. 1992;72(6):2149–56.
Alexander SL, Irvine CH, Ellis MJ, Donald RA. The effect of acute exercise on the secretion of corticotropin-releasing factor, arginine vasopressin, and adrenocorticotropin as measured in pituitary venous blood from the horse. Endocrinology. 1991;128:65–72.
Thompson DL, Weltman JY, Rogol AD, Metzger D, Veldhuis JD, Weltman A. Cholinergic and opioid involvement in release of growth hormone during exercise and recovery. J Appl Physiol. 1993;75:870–8.
Fryburg DA, Weltman A, Jahn LA, Weltman JY, Samolijik E, Veldhuis JD. Short-term modulation of the androgen milieu alters pulsatile but not exercise or GHRH-stimulated GH secretion in healthy men. J Clin Endocrinol Metab. 1997;82:3710–9.
Wideman L, Weltman JY, Shah N, Story S, Veldhuis JD, Weltman A. The effects of gender on exercise-induced growth hormone (GH) release. J Applied Physiol. 1999;87:115–62.
Kanaley JA, Weltman JY, Veldhuis JD, Rogol AD, Harman ML, Weltman A. Human growth hormone response to repeated bouts of aerobic exercise. J Appl Physiol. 1997;83:1756–61.
Weltman JY, Seip RL, Weltman AL, Snead D, Veldhuis JD, Rogol AD. Release of luteinizing hormone and growth hormone after recovery from maximal exercise. J Appl Physiol. 1990;69(1):196–200.
Pritzlaff CJ, Wideman L, Weltman JY, Abbott RD, Gutgesell ME, Hartman ML, Veldhuis JD, Weltman A. Impact of acute exercise intensity on pulsatile growth hormone release in men. J Appl Physiol. 1999 Aug;87(2):498–504.
Weltman A, Pritzlaff CJ, Wideman L, Considine RV, Fryburg DA, Gutgesell ME, Hartman ML, Veldhuis JD. Intensity of acute exercise does not affect serum leptin concentrations in young men. Med Sci Sports Exerc. 2000 Sep;32(9):1556–61.
Lehmann M, Knizia K, Gastmann U, Petersen KG, Khalaf AN, Bauer S, et al. Influence of 6-week, 6 days per week, training on pituitary function in recreational athletes. Br J Sports Med. 1993;27:186–92.
Elias AN, Wilson AF. Exercise and gonadal function. Hum Reprod. 1993;8:1747–61.
Cumming DC, Wheeler GD, MCColl EM. The effects of exercise on reproductive function in men. Sports Med. 1989;7:1–17.
McColl EM, Wheeler GD, Gomes P, Bhambhani Y, Cumming DC. The effects of acute exercise on pulsatile LH release in high-mileage male runners. Clin Endocrinol. 1989;31:617–21.
Hackney AC. Endurance training and testosterone levels. Sports Med. 1989;8:117–27.
Caston AL, Farrell PA, Deaver DR. Exercise training-induced changes in anterior pituitary gonadotrope of the female rat. J Appl Physiol. 1995;79:194–201.
Blaney J, Sothmann M, Raff H, Hart B, Horn T. Impact of exercise training on plasma adrenocorticotropin response to a well-learned vigilance task. Psychoneuroendocrinology. 1990;15:453–62.
Watanabe T, Morimoto A, Sakata Y, Wada M, Murakami N. The effect of chronic exercise on the pituitary-adrenocortical response in conscious rats. J Physiol. 1991;439:691–9.
Fellmann N, Bedu M, Boudet G, Mage M, Sagnol M, Pequignot JM, et al. Inter-relationships between pituitary-adrenal hormones and catecholamines during a 6-day Nordic ski race. Eur J Appl Physiol Occup Physiol. 1992;64:258–65.
Laatikainen TJ. Corticotropin-releasing hormone and opioid peptides in reproduction and stress. Ann Med. 1991;23:489–96.
Bonen A, Keizer HA. Pituitary, ovarian, and adrenal hormone responses to marathon running. Int J Sports Med. 1987;3:161–7.
Pestell RG, Hurley DM, Vandongen R. Biochemical and hormonal changes during a 1000 km ultramarathon. Clin Exp Pharmacol Physiol. 1989;16:353–61.
Friedl KE, Plymate SR, Bernhard WN, Mohr LC. Elevation of plasma estradiol in healthy men during a mountaineering expedition. Horm Metab Res. 1988;20:239–42.
Iranmanesh A, Lizarralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab. 1991;73:1081–8.
Veldhuis JD, Iranmanesh A, Ho KKY, Lizarralde G, Waters MJ, Johnson ML. Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab. 1991;72:51–9.
Veldhuis JD, Iranmanesh A, Evans WS, Lizarralde G, Thorner MO, Vance ML. Amplitude suppression of the pulsatile mode of immunoradiometric LH release in fasting-induced hypoandrogenemia in normal men. J Clin Endocrinol Metab. 1993;76:587–93.
Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E, et al. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. J Clin Endocrinol Metab. 1992;74:757–65.
Weltman A, Weltman JY, Hartman ML, Abbott RA, Rogol AD, Evans WS, et al. Relationship between age, percentage body fat, fitness and 24 hour growth hormone release in healthy young adults: effects of gender. J Clin Endocrinol Metab. 1994;78:543–8.
Veldhuis JD, Urban RJ, Lizarralde G, Johnson ML, Iranmanesh A. Attenuation of luteinizing hormone secretory burst amplitude is a proximate basis for the hypoandrogenism of healthy aging in men. J Clin Endocrinol Metab. 1992;75:52–8.
Bergendahl M, Vance ML, Iranmanesh A, Thorner MO, Veldhuis JD. Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men. J Clin Endocrinol Metab. 1996;81:692–9.
Aloi JA, Bergendahl M, Iranmanesh A, Veldhuis JD. Pulsatile intravenous gonadotropin-releasing hormone administration averts fasting-induced hypogonadotropism and hypoandrogenemia in healthy, normal-weight men. J Clin Endocrinol Metab. 1997;82:1543–8.
Veldhuis JD, Kulin HE, Warner BA, Santner SJ. Responsiveness of gonadotropin secretion to infusion of an opiate-receptor antagonist in hypogonadotropic individuals. J Clin Endocrinol Metab. 1982;55:649–53.
Iranmanesh A, Grisso B, Veldhuis JD. Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab. 1994;78:526–35.
Veldhuis JD, Liem AY, South S, Weltman A, Weltman J, Clemmons DA, et al. Differential impact of age, sex-steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab. 1995;80:3209–22.
Roubenoff R, Rall LC, Veldhuis JD, Kehayias JJ, Rosen C, Nicolson M, et al. The relationship between growth hormone kinetics and sarcopenia in postmenopausal women: the role of fat mass and leptin. J Clin Endocrinol Metab. 1998;83:1502–6.
Vahl N, Jorgensen JOL, Skjaerback C, Veldhuis JD, Orskov HJ, Christiansen J. Abdominal adiposity rather than age and sex predicts the mass and patterned regularity of growth hormone secretion in mid-life healthy adults. Am J Phys. 1997;272:E1108–16.
Ho KY, Veldhuis JD, Johnson ML, Furlanetto R, Evans WS, Alberti KG, et al. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest. 1988;81:968–75.
Bergendahl M, Iranmanesh A, Evans WS, Veldhuis JD. Short-term fasting selectively suppresses leptin pulse mass and 24-hour rhythmic leptin release in healthy mid-luteal phase women without disturbing leptin pulse frequency or its entropy control (pattern orderliness). J Clin Endocrinol Metab. 1999;83:883–94.
Walberg-Rankin J, Gwazdauskas FC. Response of beta-endorphin and estradiol to resistance exercise in female during energy balance and energy restriction. Int J Sports Med. 1992;13:542–7.
Garcia-Rudaz MC, Ropelato MG, Escobar ME, Veldhuis JD, Barontini M. Augmented frequency and mass of LH discharged per burst are accompanied by marked disorderliness of LH secretion in adolescents with polycystic ovary syndrome. Eur J Endocrinol. 1998;139:621–30.
Veldhuis JD, Johnson ML, Bolton WK. Analyzing pulsatile endocrine data in patients with chronic renal failure: a brief review of deconvolution techniques. Pediatr Nephrol. 1991;5:522–8.
Van den Berg G, Veldhuis JD, Frolich M, Roelfsema F. An amplitude-specific divergence in the pulsatile mode of GH secretion underlies the gender difference in mean GH concentrations in men and premenopausal women. J Clin Endocrinol Metab. 1996;81:2460–6.
Veldhuis JD, Metzger DL, Martha PM Jr, Mauras N, Kerrigan JR, Keenan B, et al. Estrogen and testosterone, but not a non-aromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. J Clin Endocrinol Metab. 1997;82:3414–20.
Roelfsema F, Van den Berg G, Frolich M, Veldhuis JD, van Eijk A, Buurman MM, et al. Sex-dependent alteration in cortisol response to endogenous adrenocorticotropin. J Clin Endocrinol Metab. 1993;77:234–40.
Van den Berg G, Pincus SM, Veldhuis JD, Frolich M, Roelfsema F. Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing’s disease. Eur J Endocrinol. 1997;136:394–400.
Mulligan T, Iranmanesh A, Johnson ML, Straume M, Veldhuis JD. Aging alters feedforward and feedback linkages between LH and testosterone in healthy men. Am J Phys. 1997;42:R1407–13.
Pincus SM, Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M, Veldhuis JD. Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males: dual novel facets. Proc Natl Acad Sci U S A. 1996;93:14100–5.
Keenan DM, Veldhuis JD, Sun W. A stochastic biomathematical model of the male reproductive hormone system. SIAM J Appl Math. 2000;61(3):934–65.
Rogol AD, Martha PM Jr, Johnson ML, Veldhuis JD, Blizzard RM. Growth hormone secretory dynamics during puberty. In: Adashi EY, Thorner MO, editors. The somatotrophic axis and the reproductive process in health and disease. New York: Springer; 1996. p. 69–82.
Veldhuis JD. Male hypothalamic–pituitary–gonadal axis. In: Lipshultz LI, Howards SS, editors. Infertility in the male. Philadelphia: Mosby-Year Book; 1996. p. 23–58.
Veldhuis JD, Iranmanesh A, Rogol AD, Urban RJ. Regulatory actions of testosterone on pulsatile growth hormone secretion in the human: studies using deconvolution analysis. In: Adashi EY, Thorner MO, editors. Somatotropic axis and the reproductive process in health and disease. New York: Springer; 1995. p. 40–57.
Veldhuis JD. Gender differences in secretory activity of the human somatotropic (GH) axis. Eur J Endocrinol. 1997;134:287–95.
Veldhuis JD. Neuroendocrine mechanisms mediating awakening of the gonadotropic axis in puberty. Pediatr Nephrol. 1996;10:304–17.
Mauras N, Rogol AD, Haymond MW, Veldhuis JD. Sex steroids, growth hormone, IGF-I: neuroendocrine and metabolic regulation in puberty. Horm Res. 1996;45:74–80.
Theintz GE, Howald H, Weiss U, Sizonenko PC. Evidence for a reduction of growth potential in adolescent female gymnasts. J Pediatr. 1993;122:306–13.
Dawson-Hughes B, Stern D, Goldman J, Reichlin S. Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: effect of physiological estrogen replacement therapy. J Clin Endocrinol Metab. 1986;63:424–32.
Weltman A, Seip RL, Snead D, Weltman JY, Evans WS, Veldhuis JD, et al. Exercise training at and above the lactate threshold in previously untrained women. Int J Sports Med. 1992;13(3):257–63.
Pincus SM, Gevers E, Robinson ICA, Roelfsema F, Hartman ML, Veldhuis JD. Females secrete growth hormone with more process irregularity than males in both human and rat. Am J Phys. 1996;270:E107–15.
Veldhuis JD. Pulsatile hormone release as a window into the brain’s control of the anterior pituitary gland in health and disease: implications and consequences of pulsatile luteinizing hormone secretion. Endocrinologist. 1995;5:454–69.
Veldhuis JD. Issues in quantifying pulsatile neurohormone release. In: Van de Kar LD, editor. Methods in neuroendocrinology: the cellular and molecular neuropharmacology series. Boca Raton: CRC; 1998. p. 181–203.
Veldhuis JD. New modalities for understanding dynamic regulation of the somatotropic (GH) axis: explication of gender differences in GH neuroregulation in the human. J Pediatr Endocrinol. 1996;9:237–53.
Veldhuis JD, Iranmanesh A, Johnson ML, Lizarralde G. Twenty-four hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. J Clin Endocrinol Metab. 1990;71:1616–23.
Veldhuis JD. A parsimonious model of amplitude and frequency modulation of episodic hormone secretory bursts as a mechanism for ultradian signaling by endocrine glands. In: Wever R, Kleitman N, editors. Ultradian rhythms in life processes: an inquiry into fundamental principles. London: Springer; 1992. p. 139–72.
Veldhuis JD, Iranmanesh A, Johnson ML, Lizarralde G. Amplitude, but not frequency, modulation of ACTH secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man. J Clin Endocrinol Metab. 1990;71:452–63.
Hartman ML, Pincus SM, Johnson ML, Matthews DH, Faunt LM, Vance ML, et al. Enhanced basal and disorderly growth hormone (GH) secretion distinguish acromegalic from normal pulsatile GH release. J Clin Invest. 1994;94:1277–88.
Pincus SM, Veldhuis JD, Mulligan T, Iranmanesh A, Evans WS. Effects of age on the irregularity of LH and FSH serum concentrations in women and men. Am J Phys. 1997;273:E989–95.
Siragy HM, Vieweg WVR, Pincus SM, Veldhuis JD. Increased disorderliness and amplified basal and pulsatile aldosterone secretion in patients with primary aldosteronism. J Clin Endocrinol Metab. 1995;80:28–33.
Van den Berg G, Pincus SM, Frolich M, Veldhuis JD, Roelfsema F. Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery. Eur J Endocrinol. 1998;138:164–9.
Schmitz O, Porksen N, Nyholm B, Skjaerback C, Butler PC, Veldhuis JD, et al. Disorderly and nonstationary insulin secretion in glucose-tolerant relatives of patients with NIDDM. Am J Phys. 1997;35:E218–26.
Meneilly GS, Ryan AS, Veldhuis JD, Elahi D. Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals. J Clin Endocrinol Metab. 1997;82:4088–93.
Johnson ML, Veldhuis JD. Evolution of deconvolution analysis as a hormone pulse detection method. Methods Neurosci. 1995;28:1–24.
Veldhuis JD, Johnson ML. Specific methodological approaches to selected contemporary issues in deconvolution analysis of pulsatile neuroendocrine data. Methods Neurosci. 1995;28:25–92.
Veldhuis JD, Evans WS, Johnson ML. Complicating effects of highly correlated model variables on nonlinear least-squares estimates of unique parameter values and their statistical confidence intervals: estimating basal secretion and neurohormone half-life by deconvolution analysis. Methods Neurosci. 1995;28:130–8.
Loucks AB, Laughlin GA, Mortola JF, Girton L, Nelson JC, Yen SS. Hypothalamic–pituitary–thyroidal function in eumenorrheic and amenorrheic athletes. J Clin Endocrinol Metab. 1992;75:514–8.
Rogol AD, Veldhuis JD, Williams FT, Johnson ML. Pulsatile secretion of gonadotropins and pro-lactin in male marathon runners: relation to the endogenous opiate system. J Androl. 1983;5:21–7.
Bagatell CJ, Bremner WJ. Sperm counts and reproductive hormones in male marathoners and lean controls. Fertil Steril. 1990;53:688–92.
Arce JC, De Souza MJ. Exercise and male factor infertility. Sports Med. 1993;15:146–9.
Lucia A, Chicharro JL, Perez M, Serratosa L, Bandres EF, Legido JC. Reproductive function in male endurance athletes: sperm analysis and hormonal profiles. J Appl Physiol. 1996;81:2627–36.
Celani MF, Grandi M. The pituitary-testicular axis in non-professional soccer players. Exp Clin Endocrinol. 1989;94:244–52.
Vasankari TJ, Kujala UM, Taimela S, Huhtaniemi IT. Pituitary-gonadal response to gonadotropin-releasing hormone stimulation is enhanced in men after strenuous physical exercise. Acta Endocrinol. 1993;129:9–14.
Keenan DM, Veldhuis JD. A biomathematical model of time-delayed feedback in the human male hypothalamic–pituitary–Leydig cell axis. Am J Phys. 1998;275:E157–76.
Veldhuis JD, Johnson ML. Analytical methods for evaluating episodic secretory activity within neuroendocrine axes. Neurosci Biobehav Rev. 1994;18:605–12.
Keenan D, Veldhuis JD. A stochastic model of admixed basal and pulsatile hormone secretion as modulated by a deterministic oscillator. Am J Phys. 1997;273:R1182–92.
Bergendahl M, Veldhuis JD. Altered pulsatile gonadotropin signaling in nutritional deficiency in the male. Trends Endocrinol Metab. 1995;6:145–59.
Frager MS, Pieper DR, Tonetta SA, Duncan JA, Marshall JC. Pituitary gonadotropin-releasing hormone receptors: effects of castration, steroid replacement, and the role of gonadotropin-releasing hormone in modulating receptors in the rat. J Clin Invest. 1991;67(3):615–23.
Bergendahl M, Evans WS, Veldhuis JD. Current concepts on ultradian rhythms of luteinizing hormone secretion in the human. Hum Reprod Update. 1996;2:507–18.
Licinio J, Negrao AB, Mantzoros C, Kaklamani V, Wong M-L, Bongiorno PB, et al. Synchronicity of frequently-sampled 24-hour concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. Proc Natl Acad Sci U S A. 1998;95:2541–6.
Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets on leptin action in rat hypothalamus. J Clin Invest. 1996;98:1101–6.
Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. Leptin accelerates the onset of puberty in normal female mice. J Clin Invest. 1997;99:391–5.
Vasankari TJ, Kujala UM, Viljanen TT, Huhtaniemi IT. Carbohydrate ingestion during prolonged running exercise results in an increase of serum cortisol and decrease of gonadotrophins. Acta Physiol Scand. 1991;141:373–7.
Tabata I, Ogita F, Miyachi M, Shibayama H. Effect of low blood glucose on plasma CRF, ACTH, and cortisol during prolonged physical exercise. J Appl Physiol. 1991;71:1807–12.
Matkovic V, Ilich JZ, Skugor M, Badenhop NE, Goel P, Clairmont A, et al. Leptin is inversely related to age at menarche in human females. J Clin Endocrinol Metab. 1997;82:3239–45.
Wade GN, Schneider JE, Li HY. Control of fertility by metabolic cues. Am J Phys. 1996;270:E1–19.
Mastrogiacomo I, Toderini D, Bonanni G, Bordin D. Gonadotropin decrease induced by prolonged exercise at about 55% of the VO2max in different phases of the menstrual cycle. Int J Sports Med. 1990;11:198–203.
Botticelli G, Bacchi Modena A, Bresciani D, Villa P, Aguzzoli L, Florio P, et al. Effect of naltrexone treatment on the treadmill exercise-induced hormone release in amenorrheic women. J Endocrinol Investig. 1992;15:839–47.
Kanaley JA, Boileau RA, Bahr JM, Misner JE, Nelson RA. Cortisol levels during prolonged exercise: the influence of menstrual phase and menstrual status. Int J Sports Med. 1992;13:332–6.
Hohtari H, Elovainio R, Salminen K, Laatikainen T. Plasma corticotropin-releasing hormone, corticotropin, and endorphins at rest and during exercise in eumenorrheic and amenorrheic athletes. Fertil Steril. 1988;50:233–8.
Samuels MH, Sanborn CF, Hofeldt F, Robbins R. The role of endogenous opiates in athletic amenorrhea. Fertil Steril. 1991;565:507–12.
Harber VJ, Sutton JR, MacDougall JD, Woolever CA, Bhavnani BR. Plasma concentrations of beta-endorphin in trained eumenorrheic and amenorrheic women. Fertil Steril. 1997;67:648–53.
Hohtari H, Salminen-Lappalainen K, Laatikainen T. Response of plasma endorphins, corticotropin, cortisol, and luteinizing hormone in the corticotropin-releasing hormone stimulation test in eumenorrheic and amenorrheic athletes. Fertil Steril. 1991;55:276–80.
Armeanu MC, Lambalk CB, Berkhout GM, Schoemaker J. Effects of opioid antagonism with naltrexone on pulsatile luteinizing hormone secretion in women with hypothalamic amenorrhea in basal conditions and after discontinuation of treatment with pulsatile LHRH. Gynecol Endocrinol. 1992;6:3–12.
Loucks AB, Mortola JF, Girton L, Yen SS. Alterations in the hypothalamic–pituitary–ovarian and the hypothalamic–pituitary–adrenal axes in athletic women. J Clin Endocrinol Metab. 1989;68:402–11.
De Cree C, Van Kranenburg G, Geurten P, Fujimori Y, Keizer HA. 4-Hydroxycatecholestrogen metabolism responses to exercise and training: possible implications for menstrual cycle irregularities and breast cancer. Fertil Steril. 1997;67:505–16.
Dugowson CE, Drinkwater BL, Clark JM. Nontraumatic femur fracture in an oligomenorrheic athlete. Med Sci Sports Exerc. 1991;23:1323–5.
Baker E, Demers L. Menstrual status in female athletes: correlations with reproductive hormones and bone density. Obstet Gynecol. 1988;72:683–7.
Marcus R, Cann C, Madvig P, Minkoff J, Goddard M, Bayer M, et al. Menstrual function and bone mass in elite women distance runners: endocrine and metabolic features. Ann Intern Med. 1985;102:158–63.
Wright NM, Renault J, Willi S, Veldhuis JD, Gordon L, Key LL, et al. Greater secretion of growth hormone in black than in white males: possible factor in greater bone mineral density. J Clin Endocrinol Metab. 1995;80:2291–7.
Acknowledgments
We thank Patsy Craig for her skillful preparation of the manuscript and Paula P. Azimi for the data analysis, management, and graphics. This work was supported in part by NIH Grant MO1 RR00847 (to the General Clinical Research Center of the University of Virginia Health Sciences Center), Research Career Development Award 1-KO4-HD-00634 (to J. D. V.), the Baxter Healthcare Corporation (Round Lake, IL, to J. D. V.), the NIH-supported Clinfo Data Reduction Systems, the University of Virginia Pratt Foundation and Academic Enhancement Program, the National Science Foundation Center for Biological Timing (Grant DIR89-20162), and the NIH NICHD U54 Center for Reproduction Research (HD96008).
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Veldhuis, J.D., Yoshida, K. (2020). Impact of Chronic Training on Pituitary Hormone Secretion in Humans. In: Hackney, A., Constantini, N. (eds) Endocrinology of Physical Activity and Sport. Contemporary Endocrinology. Humana, Cham. https://doi.org/10.1007/978-3-030-33376-8_4
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DOI: https://doi.org/10.1007/978-3-030-33376-8_4
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