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Cyclic di-GMP Signaling in Salmonella enterica serovar Typhimurium

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Microbial Cyclic Di-Nucleotide Signaling

Abstract

Cyclic di-GMP is perhaps the most abundant nucleotide-based second messenger in bacteria. In the gamma-proteobacterium Salmonella enterica serovar Typhimurium, a gastrointestinal pathogen, this signaling network regulates biofilm formation, flagella-associated physiology, and acute virulence properties. This chapter summarizes the impact of the complex cyclic di-GMP signaling network on the physiology of S. typhimurium in different environments and compares its consequences, when appropriate, with the close relative, the commensal and pathogenic Escherichia coli. The substantial diversity and variability in the cyclic di-GMP turnover protein network span from single amino acid replacements and stop codon variants in individual proteins to deletion and acquisition of novel cyclic di-GMP turnover genes by horizontal transfer. Despite differences in enzyme activities and gene combinations, cyclic di-GMP signaling modules become integrated into a common but even isolate-specific regulation of lifestyle transitions that are coordinated with cell cycle regulation. On a wider phylogenetic perspective, the observed conservation of cyclic di-GMP turnover proteins with a similar domain structure found in S. enterica throughout the phylogenetic tree poses a quest for the origin and maintenance of common principles in cyclic di-GMP signaling.

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Acknowledgments

UR appreciates the constructive comments of the reviewers of this manuscript and appreciates the engagement of former and present coworkers. Research in the laboratory of UR is supported by funding from the Swedish Research Council Natural Sciences and Engineering, Swedish Research Links, and the European Commission.

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  1. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

    Ute Römling

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  1. Institute of Biochemistry and Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan

    Shan-Ho Chou

  2. Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile

    Nicolas Guiliani

  3. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA

    Vincent T. Lee

  4. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

    Ute Römling

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Römling, U. (2020). Cyclic di-GMP Signaling in Salmonella enterica serovar Typhimurium. In: Chou, SH., Guiliani, N., Lee, V., Römling, U. (eds) Microbial Cyclic Di-Nucleotide Signaling. Springer, Cham. https://doi.org/10.1007/978-3-030-33308-9_24

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