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Metabolic Regulation by Cyclic di-AMP Signaling

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Microbial Cyclic Di-Nucleotide Signaling

Abstract

The year 2018 marks the 10-year anniversary of the discovery of the diadenylate cyclase enzyme and its capacity to synthesize the broadly conserved second messenger cyclic di-AMP. Since this discovery, our understanding of the physiological processes controlled by this dinucleotide has advanced rapidly, with the discovery of both cyclic di-AMP responsive riboswitch gene control elements and protein binding partners. Additionally, cyclic di-AMP has been implicated as a cross-kingdom signal between bacteria and eukaryotic hosts. While the physiological processes modulated by these signaling partners are as diverse as the bacteria that produce cyclic di-AMP, a key theme that has emerged is the regulation of cellular metabolism. In this chapter, we will focus on the biological impacts of metabolic regulation imposed by cyclic di-AMP at both the transcriptional/translational and posttranslational levels, as well as the molecular mechanism of this regulation. We will highlight the regulation of central carbon metabolism through pyruvate carboxylase, the regulation of cell wall metabolism through the ydaO riboswitch, and the impact on host cell inflammatory response through competitive inhibition of the host binding protein RECON.

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Acknowledgment

The research on cyclic di-AMP signaling in the authors’ laboratories is supported by NIH grant R01AI116669.

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Authors and Affiliations

  1. Department of Biological Sciences, Columbia University, New York, NY, USA

    Liang Tong

  2. Department of Microbiology, University of Washington, Seattle, WA, USA

    Joshua J. Woodward

Authors
  1. Liang Tong
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  2. Joshua J. Woodward
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Corresponding authors

Correspondence to Liang Tong or Joshua J. Woodward .

Editor information

Editors and Affiliations

  1. Institute of Biochemistry and Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan

    Shan-Ho Chou

  2. Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile

    Nicolas Guiliani

  3. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA

    Vincent T. Lee

  4. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

    Ute Römling

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Tong, L., Woodward, J.J. (2020). Metabolic Regulation by Cyclic di-AMP Signaling. In: Chou, SH., Guiliani, N., Lee, V., Römling, U. (eds) Microbial Cyclic Di-Nucleotide Signaling. Springer, Cham. https://doi.org/10.1007/978-3-030-33308-9_10

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