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The Role of the Mitochondria in SAMS

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Statin-Associated Muscle Symptoms

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

In this chapter we summarize the evidence for a central role of mitochondrial dysfunction in statin-associated muscle symptoms. Statin-related mitochondrial dysfunction can manifest itself in skeletal muscle by inducing a plethora of architectural and biochemical adaptations. Structural changes seen in biopsy specimens, including red ragged fibers, cytochrome oxidase-negative myofibers, and lipid-loaded vacuoles, are signs of mitochondrial respiratory chain dysfunction. Disturbances in mitochondrial energy metabolism are shown through increased lactate/pyruvate ratios, disruption of beta-oxidation, a decrease in mitochondrial DNA, and disturbances in electron transport chain complex activities. Apoptosis of myofibers may occur as a result of mitochondrial-mediated apoptosis and the formation of reactive oxygen species. Furthermore the role of coenzyme Q10 deficiency and disturbances in calcium homeostasis in relation to statin-induced mitochondrial dysfunction will be discussed.

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Author information

Authors and Affiliations

  1. Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

    Neeltje A. E. Allard

  2. Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

    Silvie Timmers

  3. Human and Animal Physiology, Wageningen University & Research, Wageningen, The Netherlands

    Silvie Timmers

Authors
  1. Neeltje A. E. Allard
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  2. Silvie Timmers
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Corresponding author

Correspondence to Neeltje A. E. Allard .

Editor information

Editors and Affiliations

  1. Hartford Hospital, University of Connecticut, Hartford, CT, USA

    Paul D. Thompson

  2. Hartford Hospital, University of Connecticut, Hartford, CT, USA

    Beth A. Taylor

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Allard, N.A.E., Timmers, S. (2020). The Role of the Mitochondria in SAMS. In: Thompson, P., Taylor, B. (eds) Statin-Associated Muscle Symptoms. Contemporary Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-33304-1_12

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  • DOI: https://doi.org/10.1007/978-3-030-33304-1_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-33303-4

  • Online ISBN: 978-3-030-33304-1

  • eBook Packages: MedicineMedicine (R0)

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