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Evidence-Based Analysis of Neurotransmitter Modulation by Gut Microbiota

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Health Information Science (HIS 2019)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 11837))

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Abstract

Gut microbiota that lives in the human gastrointestinal tract impacts on the mental illness through the neurotransmitter-mediated pathway. It’s well known that the imbalance of neurotransmitter leads to mental problems. The association between gut microbiota and neurotransmitter needs to be explored in depth. In this paper, we aim at identifying the quality evidence of neurotransmitter modulation by gut microbiota. We use evidence-based medical analysis to characterize the relevant articles to five levels in terms of the strength and reliability of evidence. Thirty-four articles are identified to evaluate their evidence. Gut microbiota not only produces neurotransmitters directly but also modulates neurotransmitters level via metabolism pathways. Also, the growth of some gut microbiota can be counter-regulated by neurotransmitters. This paper provides a comprehensive picture of the association between gut microbiota and neurotransmitter, which give researchers an insight into neurotransmitter modulation by gut microbiota.

This work was partially supported by the China Scholarship Council.

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Authors and Affiliations

  1. Computer Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

    Ting Liu & Zhisheng Huang

  2. Computer Science, Brain Protection Innovation Center, Capital Medical University, Beijing, China

    Zhisheng Huang

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  1. Ting Liu
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  2. Zhisheng Huang
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Correspondence to Zhisheng Huang .

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Editors and Affiliations

  1. Victoria University, Footscray, VIC, Australia

    Hua Wang

  2. Victoria University, Footscray, VIC, Australia

    Siuly Siuly

  3. Swinburne University of Technology, Hawthorn, VIC, Australia

    Rui Zhou

  4. Instituto de Salud Carlos III, Madrid, Spain

    Fernando Martin-Sanchez

  5. Victoria University, Footscray, VIC, Australia

    Yanchun Zhang

  6. Vrije University, Amsterdam, The Netherlands

    Zhisheng Huang

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Liu, T., Huang, Z. (2019). Evidence-Based Analysis of Neurotransmitter Modulation by Gut Microbiota. In: Wang, H., Siuly, S., Zhou, R., Martin-Sanchez, F., Zhang, Y., Huang, Z. (eds) Health Information Science. HIS 2019. Lecture Notes in Computer Science(), vol 11837. Springer, Cham. https://doi.org/10.1007/978-3-030-32962-4_22

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  • DOI: https://doi.org/10.1007/978-3-030-32962-4_22

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