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Migrastatics – Anti-metastatic Drugs Targeting Cancer Cell Invasion

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Approaching Complex Diseases

Part of the book series: Human Perspectives in Health Sciences and Technology ((HPHST,volume 2))

Abstract

Metastatic cancer cells are characterized by uncontrolled proliferation and invasive behavior. In solid tumors, mortality is caused by invasive and metastatic activity of tumor cells rather than their proliferative ability. Therefore, the treatment of solid tumors should be supplemented with drugs that suppress the ability of tumor cells to invade through the surrounding extracellular matrix and form secondary tumors. During invasion, metastatic cancer cells can utilize various invasion modes, which stresses the need to target mechanisms common to all invasion modes. Here, we summarize the concept of migrastatics, which refers to drugs targeting all forms of cancer cell invasion. We overview the most potential migrastatic candidates and discuss their advantages and disadvantages.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, Charles University, Prague, Czech Republic

    Aneta Gandalovičová, Daniel Rosel & Jan Brábek

  2. Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Vestec u Prahy, Czech Republic

    Aneta Gandalovičová, Daniel Rosel & Jan Brábek

Authors
  1. Aneta Gandalovičová
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  2. Daniel Rosel
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  3. Jan Brábek
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Correspondence to Jan Brábek .

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Editors and Affiliations

  1. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

    Mariano Bizzarri

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Gandalovičová, A., Rosel, D., Brábek, J. (2020). Migrastatics – Anti-metastatic Drugs Targeting Cancer Cell Invasion. In: Bizzarri, M. (eds) Approaching Complex Diseases. Human Perspectives in Health Sciences and Technology, vol 2. Springer, Cham. https://doi.org/10.1007/978-3-030-32857-3_9

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