Skip to main content

Globally-Aware Multiple Instance Classifier for Breast Cancer Screening

  • Conference paper
  • First Online:
Machine Learning in Medical Imaging (MLMI 2019)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 11861))

Included in the following conference series:

Abstract

Deep learning models designed for visual classification tasks on natural images have become prevalent in medical image analysis. However, medical images differ from typical natural images in many ways, such as significantly higher resolutions and smaller regions of interest. Moreover, both the global structure and local details play important roles in medical image analysis tasks. To address these unique properties of medical images, we propose a neural network that is able to classify breast cancer lesions utilizing information from both a global saliency map and multiple local patches. The proposed model outperforms the ResNet-based baseline and achieves radiologist-level performance in the interpretation of screening mammography. Although our model is trained only with image-level labels, it is able to generate pixel-level saliency maps that provide localization of possible malignant findings.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bergstra, J., Bengio, Y.: Random search for hyper-parameter optimization. J. Mach. Learn. Res. 13(Feb), 281–305 (2012)

    MathSciNet  MATH  Google Scholar 

  2. Deng, J., Dong, W., Socher, R., Li, L.J., Li, K., Fei-Fei, L.: ImageNet: a large-scale hierarchical image database. In: CVPR 2009 (2009)

    Google Scholar 

  3. Diba, A., Sharma, V., Pazandeh, A.M., Pirsiavash, H., Van Gool, L.: Weakly supervised cascaded convolutional networks. In: CVPR (2017)

    Google Scholar 

  4. Durand, T., Mordan, T., Thome, N., Cord, M.: Wildcat: weakly supervised learning of deep convnets for image classification, pointwise localization and segmentation. In: CVPR (2017)

    Google Scholar 

  5. Gao, Y., Geras, K.J., Lewin, A.A., Moy, L.: New frontiers: an update on computer-aided diagnosis for breast imaging in the age of artificial intelligence. Am. J. Roentgenol. 212(2), 300–307 (2019)

    Article  Google Scholar 

  6. Ilse, M., Tomczak, J.M., Welling, M.: Attention-based deep multiple instance learning. arXiv:1802.04712 (2018)

  7. Kingma, D., Ba, J.: Adam: a method for stochastic optimization. In: ICLR (2015)

    Google Scholar 

  8. Kopans, D.B.: Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality. Cancer 94(2), 580–581 (2002)

    Article  Google Scholar 

  9. Ren, S., He, K., Girshick, R., Sun, J.: Faster R-CNN: towards real-time object detection with region proposal networks. In: NIPS (2015)

    Google Scholar 

  10. Ribli, D., Horváth, A., Unger, Z., Pollner, P., Csabai, I.: Detecting and classifying lesions in mammograms with deep learning. Sci. Rep. 8(1), 4165 (2018)

    Article  Google Scholar 

  11. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv:1409.1556 (2014)

  12. Wang, N., et al.: Densely deep supervised networks with threshold loss for cancer detection in automated breast ultrasound. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11073, pp. 641–648. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00937-3_73

    Chapter  Google Scholar 

  13. Wu, N., et al.: Breast density classification with deep convolutional neural networks. In: ICASSP (2018)

    Google Scholar 

  14. Wu, N., et al.: Deep neural networks improve radiologists’ performance in breast cancer screening. arXiv preprint arXiv:1903.08297 (2019)

  15. Yao, L., Prosky, J., Poblenz, E., Covington, B., Lyman, K.: Weakly supervised medical diagnosis and localization from multiple resolutions. arXiv:1803.07703 (2018)

  16. Zhu, W., Lou, Q., Vang, Y.S., Xie, X.: Deep multi-instance networks with sparse label assignment for whole mammogram classification. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10435, pp. 603–611. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66179-7_69

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yiqiu Shen .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Shen, Y. et al. (2019). Globally-Aware Multiple Instance Classifier for Breast Cancer Screening. In: Suk, HI., Liu, M., Yan, P., Lian, C. (eds) Machine Learning in Medical Imaging. MLMI 2019. Lecture Notes in Computer Science(), vol 11861. Springer, Cham. https://doi.org/10.1007/978-3-030-32692-0_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-32692-0_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-32691-3

  • Online ISBN: 978-3-030-32692-0

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics