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Transcriptomics and Metabolomics in Amyotrophic Lateral Sclerosis

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GeNeDis 2018

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1195))

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving progressive and selective loss of motor neurons, muscle weakness, paralysis and death. The pathogenesis of ALS is not clearly understood, while reliable prognostic markers have not been identified to detect symptoms at earlier time points. The rapid development of microarray technology offers great potential for simultaneous analysis of the transcriptional expression of thousands of genes, aiming to determine novel candidate targets for efficient treatment. Additionally, metabolomics, as a high-throughput approach, is gaining significant attention in ALS research providing an opportunity to develop predictive biomarkers that may be utilized as indicators of clinical symptoms of ALS. In this review, recent evidences from gene expression profiling studies in ALS are illustrated in order to examine molecular signatures related to the disease’s pathogenesis and potential discovery of therapeutic targets. Moreover, potent challenges are presented regarding the utilization of the metabolomics approach as a diagnostic tool in context with distinctive biomarkers’ identification.

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Authors and Affiliations

  1. National Center for Scientific Research “Demokritos”, Institute of Nanoscience and Nanotechnology, Patriarchou Grigoriou & Neapoleos, Athens, Greece

    Marios G. Krokidis

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  1. Marios G. Krokidis
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Correspondence to Marios G. Krokidis .

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Editors and Affiliations

  1. Department of Informatics, Ionian University, Corfu, Greece

    Panayiotis Vlamos

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Krokidis, M.G. (2020). Transcriptomics and Metabolomics in Amyotrophic Lateral Sclerosis. In: Vlamos, P. (eds) GeNeDis 2018. Advances in Experimental Medicine and Biology, vol 1195. Springer, Cham. https://doi.org/10.1007/978-3-030-32633-3_29

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