Skip to main content

Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionism

  • Chapter
  • First Online:
HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design

Abstract

Fifty years after the elucidation of the double helix structure of DNA, heralded by some as providing the solution to the mystery of life, an increasing number of biologists have become critical of the reductionist view that biological systems can be fully explained by the physico-chemical properties of their constituent parts. Biology is increasingly regarded as an autonomous discipline requiring its own explanatory concepts not found in chemistry and physics, and it has become accepted that biological systems can only be understood in terms of their evolutionary history on Earth. The current rejection of reductionism as an acceptable approach for explaining biological phenomena may seem paradoxical since the value of reductionism as a research strategy for dissecting and analysing the constituents of biological systems has never been questioned. The outstanding success of molecular biology in unravelling the structural and chemical basis of living processes is indeed a clear testimony of the value of reductionism as an analytical methodology.

Journal of Molecular Recognition, 2004, 17, 145–148.

Marc H V Van Regenmortel

Copyright © 2004 John Wiley and Sons

All rights reserved, used with permission

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Achinstein P. The nature of explanation. Oxford University Press: New York; 1983.

    Google Scholar 

  • Bock G, Goode J. The limits of reductionism in biology. Novartis Foundation Symposium no. 213. Chichester: Wiley; 1998.

    Google Scholar 

  • Byerly H. Reductionism: analysis and synthesis in biological explanations. Q Rev Biol. 2003;78:336–42.

    Google Scholar 

  • Fox-Keller E. Making sense of life. Explaining biological development with models, metaphors and machines. Cambridge, MA: Harward University Press; 2002.

    Google Scholar 

  • Mahner M, Bunge M. Foundations of biophilosophy. Springer: Berlin; 1997.

    Google Scholar 

  • Morange M. A history of molecular biology. Cambridge, MA: Harvard University Press; 1998.

    Google Scholar 

  • Morange M. A successful form of reductionism. Biochemist. 2001a;23:37–9.

    Google Scholar 

  • Schaffner K. Discovery and explanation in biology and medicine. Chicago, IL: Chicago University Press; 1993.

    Google Scholar 

  • Sonnenschein C, Soto AM. The society of cells. Cancer and control of cell proliferation. New York: Springer; 1999.

    Google Scholar 

  • Sonnenschein C, Soto AM. The somatic mutation theory of carcinogenesis: why it should be dropped and replaced. Mol Carcinog. 2000;29:1–7.

    Article  Google Scholar 

  • Van Regenmortel MHV. From absolute to exquisite specificity. Reflections on the fuzzy nature of species, specificity and antigenic sites. J Immunol Methods. 1998;216:37–48.

    PubMed  Google Scholar 

  • Van Regenmortel MHV, Hull D. Promises and limits of reductionism in the biomedical sciences. Chichester: Wiley; 2002. p. 1–377.

    Book  Google Scholar 

  • Weinstein IB. Addiction to oncogenes. The Achilles heel of cancer. Science. 2002;297:63–4.

    Article  CAS  PubMed  Google Scholar 

  • Wimsatt WC. Re-engineering philosophy for limited beings. piecewise approximations to reality. Cambridge, MA: Harvard University Press; 2007.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Van Regenmortel, M.H.V. (2019). Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionism. In: HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design. Springer, Cham. https://doi.org/10.1007/978-3-030-32459-9_7

Download citation

Publish with us

Policies and ethics