Abstract
Fifty years after the elucidation of the double helix structure of DNA, heralded by some as providing the solution to the mystery of life, an increasing number of biologists have become critical of the reductionist view that biological systems can be fully explained by the physico-chemical properties of their constituent parts. Biology is increasingly regarded as an autonomous discipline requiring its own explanatory concepts not found in chemistry and physics, and it has become accepted that biological systems can only be understood in terms of their evolutionary history on Earth. The current rejection of reductionism as an acceptable approach for explaining biological phenomena may seem paradoxical since the value of reductionism as a research strategy for dissecting and analysing the constituents of biological systems has never been questioned. The outstanding success of molecular biology in unravelling the structural and chemical basis of living processes is indeed a clear testimony of the value of reductionism as an analytical methodology.
Journal of Molecular Recognition, 2004, 17, 145–148.
Marc H V Van Regenmortel
Copyright © 2004 John Wiley and Sons
All rights reserved, used with permission
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Achinstein P. The nature of explanation. Oxford University Press: New York; 1983.
Bock G, Goode J. The limits of reductionism in biology. Novartis Foundation Symposium no. 213. Chichester: Wiley; 1998.
Byerly H. Reductionism: analysis and synthesis in biological explanations. Q Rev Biol. 2003;78:336–42.
Fox-Keller E. Making sense of life. Explaining biological development with models, metaphors and machines. Cambridge, MA: Harward University Press; 2002.
Mahner M, Bunge M. Foundations of biophilosophy. Springer: Berlin; 1997.
Morange M. A history of molecular biology. Cambridge, MA: Harvard University Press; 1998.
Morange M. A successful form of reductionism. Biochemist. 2001a;23:37–9.
Schaffner K. Discovery and explanation in biology and medicine. Chicago, IL: Chicago University Press; 1993.
Sonnenschein C, Soto AM. The society of cells. Cancer and control of cell proliferation. New York: Springer; 1999.
Sonnenschein C, Soto AM. The somatic mutation theory of carcinogenesis: why it should be dropped and replaced. Mol Carcinog. 2000;29:1–7.
Van Regenmortel MHV. From absolute to exquisite specificity. Reflections on the fuzzy nature of species, specificity and antigenic sites. J Immunol Methods. 1998;216:37–48.
Van Regenmortel MHV, Hull D. Promises and limits of reductionism in the biomedical sciences. Chichester: Wiley; 2002. p. 1–377.
Weinstein IB. Addiction to oncogenes. The Achilles heel of cancer. Science. 2002;297:63–4.
Wimsatt WC. Re-engineering philosophy for limited beings. piecewise approximations to reality. Cambridge, MA: Harvard University Press; 2007.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Van Regenmortel, M.H.V. (2019). Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionism. In: HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design. Springer, Cham. https://doi.org/10.1007/978-3-030-32459-9_7
Download citation
DOI: https://doi.org/10.1007/978-3-030-32459-9_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-32458-2
Online ISBN: 978-3-030-32459-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)