Abstract
Structure-based reverse vaccinology (RV) (Van Regenmortel 2011a) attempts to develop an HIV-1 vaccine by determining the 3-D structure of complexes of HIV-1 Env epitopes bound to broadly neutralizing monoclonal antibodies (bnMabs) (Burton 2002). For more than 10 years, hundreds of investigators have tried, without success, to transform Env epitopes of known structure into effective vaccine immunogens, because they thought that epitopes that bind to affinity-matured bnMabs would also be able to induce similar antibodies when used as immunogens (Van Regenmortel 2012a).
Frontiers in Immunology, 2016, 7, 266.
Marc H V Van Regenmortel
Copyright: © 2016 Van Regenmortel.
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A commentary on
“Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking”
by King MR. Front Immunol (2016) 7:42. doi: 10.3389/fimmu.2016.00042
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Van Regenmortel, M.H.V. (2019). Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking. In: HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design. Springer, Cham. https://doi.org/10.1007/978-3-030-32459-9_10
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