Abstract
Mild Cognitive Impairment (MCI) is the prodromal stage of Alzheimer’s disease (AD), with a high incident rate converting to AD. Hence, it is critical to identify MCI patients who will convert to AD patients for early and effective treatment. Recently, many machine learning or deep learning based methods have been proposed to first localize the pathology-related brain regions and then extract respective features for MCI progression diagnosis. However, the intrinsic relationship between pathological region localization and respective feature extraction was usually neglected. To address this issue, in this paper, we proposed a novel iterative attention focusing strategy for joint pathological region localization and identification of progressive MCI (pMCI) from stable MCI (sMCI). Moreover, by connecting diagnosis network and attention map generator, the pathological regions can be iteratively localized, and the respective diagnosis performance is in turn improved. Experiments on 393 training subjects from the ADNI-1 dataset and other 277 testing subjects from the ADNI-2 dataset show that our method can achieve 81.59% accuracy for pMCI vs. sMCI diagnosis. Our results outperform those with the state-of-the-art methods, while additionally providing a focused attention map on specific pathological locations related to MCI progression, i.e., left temporal lobe, entorhinal and hippocampus. This allows for more insights and better understanding of the progression of MCI to AD.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ashburner, J., Friston, K.J.: Voxel-based morphometry-the methods. Neuroimage 11(6), 805–821 (2000)
Galton, C.J., et al.: Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia. Neurology 57(2), 216–225 (2001)
He, K., Zhang, X., Ren, S., Sun, J.: Delving deep into rectifiers: surpassing human-level performance on imagenet classification. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 1026–1034 (2015)
Jagust, W.: Vulnerable neural systems and the borderland of brain aging and neurodegeneration. Neuron 77(2), 219–234 (2013)
Jack Jr., C.R., et al.: The Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods. J. Magn. Reson. Imaging 27(4), 685–691 (2010)
Kingma, D.P., Ba, J.: Adam: a method for stochastic optimization. arXiv preprint arXiv:1412.6980 (2014)
Lian, C., Liu, M., Zhang, J., Shen, D.: Hierarchical fully convolutional network for joint atrophy localization and Alzheimer’s disease diagnosis using structural MRI. IEEE Trans. Pattern Anal. Mach. Intell. PP(99), 1 (2018)
Lin, T.Y., Goyal, P., Girshick, R., He, K., Dollár, P.: Focal loss for dense object detection. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2980–2988 (2017)
Liu, M., Zhang, J., Adeli, E., Shen, D.: Landmark-based deep multi-instance learning for brain disease diagnosis. Med. Image Anal. 43, 157–168 (2018)
Selvaraju, R.R., Cogswell, M., Das, A., Vedantam, R., Parikh, D., Batra, D.: Grad-CAM: visual explanations from deep networks via gradient-based localization. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 618–626 (2017)
Zeiler, M.D., Fergus, R.: Visualizing and understanding convolutional networks. In: Fleet, D., Pajdla, T., Schiele, B., Tuytelaars, T. (eds.) ECCV 2014. LNCS, vol. 8689, pp. 818–833. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-10590-1_53
Zhang, D., Wang, Y., Zhou, L., Yuan, H., Shen, D.: Multimodal classification of Alzheimer’s disease and mild cognitive impairment. Neuroimage 55(3), 856–867 (2011)
Zhou, B., Khosla, A., Lapedriza, A., Oliva, A., Torralba, A.: Learning deep features for discriminative localization. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2921–2929 (2016)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this paper
Cite this paper
Li, Q. et al. (2019). Novel Iterative Attention Focusing Strategy for Joint Pathology Localization and Prediction of MCI Progression. In: Shen, D., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. MICCAI 2019. Lecture Notes in Computer Science(), vol 11767. Springer, Cham. https://doi.org/10.1007/978-3-030-32251-9_34
Download citation
DOI: https://doi.org/10.1007/978-3-030-32251-9_34
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-32250-2
Online ISBN: 978-3-030-32251-9
eBook Packages: Computer ScienceComputer Science (R0)