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Chronic Myeloid Leukemia

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Practical Lymph Node and Bone Marrow Pathology

Part of the book series: Practical Anatomic Pathology ((PAP))

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Abstract

This chapter describes the diagnostic criteria, work-up, differential diagnoses, treatment, and treatment response monitoring of chronic myeloid leukemia. The chapter also emphasizes the practical up-to-date cytogenetic aspects of chronic myeloid leukemia, including BCR-ABL1 fusion transcript subtype, variant Philadelphia chromosome (Ph), additional chromosomal abnormalities in both Ph-positive and Ph-negative cells, de novo Ph-positive acute leukemia, and Ph acquired during therapy of hematopoietic neoplasms. In addition, preleukemic phase, the early stage of chronic myeloid leukemia not included in the current WHO Classification but not uncommonly encountered during daily practice, is also emphasized in the “Case Presentations”.

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Authors and Affiliations

  1. Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA

    Ting Zhou

  2. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Shimin Hu

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  1. Ting Zhou
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  2. Shimin Hu
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Correspondence to Shimin Hu .

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Editors and Affiliations

  1. Department of Pathology, Duke University School of Medicine and Duke Health System, Durham, NC, USA

    Endi Wang

  2. Department of Pathology, Duke University School of Medicine and Duke Health System, Durham, NC, USA

    Anand Shreeram Lagoo

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Zhou, T., Hu, S. (2020). Chronic Myeloid Leukemia. In: Wang, E., Lagoo, A.S. (eds) Practical Lymph Node and Bone Marrow Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-32189-5_22

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  • DOI: https://doi.org/10.1007/978-3-030-32189-5_22

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