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Essentials of the Immune Response and Immunophenotyping

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Practical Lymph Node and Bone Marrow Pathology

Part of the book series: Practical Anatomic Pathology ((PAP))

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Abstract

Key concepts in immunology intersect the practice of hematopathology because the biology and classification of lymphoid neoplasms are best understood on this basis and accurate diagnosis of most hematolymphoid neoplasms very often relies on immune-based techniques. This chapter summarizes the fundamental divisions of the immune system at the cellular and functional level and relates these divisions to the immune responses in health and disease. The normal development of B-cells and T-cells is mapped to the anatomical and histological distribution of these cells at various stages of maturation and through immune responses. The pros and cons of the two principal techniques of determining the immunophenotype of normal and abnormal cells—multiparameter flow cytometry and immunohistochemistry—are compared. The immunophenotype of normal lymphoid cell subsets, developing myeloid cells, and major types of lymphomas and acute leukemias are presented. Finally, the rapidly expanding repertoire of antibody based therapies for hematolymphoid maligngncies is highlighted with this background of key immunologic concepts.

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Author information

Authors and Affiliations

  1. Department of Pathology, Duke University School of Medicine, Durham, NC, USA

    Chad M. McCall

  2. Hematology Laboratory Services, Duke University Health System, Durham, NC, USA

    Chad M. McCall

  3. Durham VA Medical Center, Durham, NC, USA

    Chad M. McCall

  4. Pathologists Diagnostic Services, PLLC, Winston Salem, NC, USA

    Bethany D. Vallangeon

  5. Department of Pathology, Duke University School of Medicine and Duke Health System, Durham, NC, USA

    Anand Shreeram Lagoo

Authors
  1. Chad M. McCall
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  2. Bethany D. Vallangeon
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  3. Anand Shreeram Lagoo
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Correspondence to Anand Shreeram Lagoo .

Editor information

Editors and Affiliations

  1. Department of Pathology, Duke University School of Medicine and Duke Health System, Durham, NC, USA

    Endi Wang

  2. Department of Pathology, Duke University School of Medicine and Duke Health System, Durham, NC, USA

    Anand Shreeram Lagoo

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McCall, C.M., Vallangeon, B.D., Lagoo, A.S. (2020). Essentials of the Immune Response and Immunophenotyping. In: Wang, E., Lagoo, A.S. (eds) Practical Lymph Node and Bone Marrow Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-32189-5_1

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  • DOI: https://doi.org/10.1007/978-3-030-32189-5_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-32188-8

  • Online ISBN: 978-3-030-32189-5

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