Abstract
Lung nodule progression assessment from medical imaging is a critical biomarker for assessing the course of the disease or the patient’s response to therapy. CT images are routinely used to identify the location and size and rack the progression of lung nodules. However, nodule segmentation is challenging and prone to error, due to the irregular nodule boundaries, therefore introducing error in the lung nodule quantification process. Here, we describe the development and evaluation of a feature-based affine image registration framework that enables us to register two time point thoracic CT images as a means to account for the back-ground lung tissue deformation, then use digital subtraction images to assess tumor progression/regression. We have demonstrated this method on twelve de-identified patient datasets and showed that the proposed method yielded a better than 1.5 mm registration accuracy vis-à-vis the widely accepted non-rigid image registration techniques. To demonstrate the potential clinical value of our described technique, we conducted a study in which our collaborating clinician was asked to provide an assessment of nodule progression/regression using the digital subtraction images post-registration. This assessment was consistent, yet provided more confidence, than the traditional lung nodule tracking based on visual analysis of the CT images.
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Acknowledgements
Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award No. R35GM128877 and by the Office of Advanced Cyber infrastructure of the National Science Foundation under Award No. 1808530.
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Zikri, Y.K.B., Helguera, M., Cahill, N.D., Shrier, D., Linte, C.A. (2019). Toward an Affine Feature-Based Registration Method for Ground Glass Lung Nodule Tracking. In: Tavares, J., Natal Jorge, R. (eds) VipIMAGE 2019. VipIMAGE 2019. Lecture Notes in Computational Vision and Biomechanics, vol 34. Springer, Cham. https://doi.org/10.1007/978-3-030-32040-9_26
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DOI: https://doi.org/10.1007/978-3-030-32040-9_26
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