Abstract
Muntingia calabura, commonly known as Jamaican cherry, is a plant species belonging to the family Muntingiaceae with variety of traditional uses. Following on these folklore claims, the works on phytochemicals constituents, traditional uses, pharmacological benefits and their mechanisms are presented in a number of studies as well as the in vitro and in vivo investigations. This species contains valuable phytochemicals with known medicinal properties that are beneficial to the well-being (e.g. anti-microbial, anti-nociceptive, anti-inflammatory etc.). Still, further and in-depth researches including a well-designed pharmacological tests and randomized clinical trials are required to unlock the hidden potential medicinal values of this plant, thus lead to the new drug discoveries of M. calabura.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsAbbreviations
- AEMCfr:
-
Aqueous extract M. calabura
- CECMCL:
-
Chloroform extract M. calabura leaves
- EEMCL:
-
Ethanol extract M. calabura leaves
- GCMS:
-
Gas chromatography–mass spectrometry
- HPLC:
-
High Performance Liquid Chromatography
- LCMS:
-
Liquid chromatography–mass spectrometry
- LD50:
-
Lethal dose at 50%
- MEMCfr:
-
Methanol extract M. calabura fruit
- MEMCL:
-
Methanol extract M. calabura leaves
- MIC:
-
Minimum Inhibitory Concentration
- NMR:
-
Nuclear magnetic resonance
- PEEMCL:
-
Petroleum ether extract M.calabura Leaves
References
Balan T, Mohd Sani MH, Suppaiah V, Mohtarrudin N, Suhaili Z, Ahmad Z, Zakaria ZA (2013) Antiulcer activity of Muntingia calabura leaves involves the modulation of endogenous nitric oxide and nonprotein sulfhydryl compounds. Pharm Biol 52:410–418
Bayer C, Chase MW, Fay MF (1998) Muntingiaceae, a new family of dicotyledons with Malvalean affinities. Taxon 47(1):37–42
Blench R (2008) A history of fruits on the southeast Asian mainland. Ed: Toshiki Osada and Akinori Uesugi. In: Occasional paper 4: linguistics, archeology and the human past. Indus Project Research Institute for Humanity and Nature, Kyoto. ISBN 978-4-902325-33-1
Buhian WPC, Rubio RO, Valle DLJ, Martin-Puzon JJ (2016) Bioactive metabolite profiles and antimicrobial activity of ethanolic extracts from Muntingia calabura L. leaves and stems. Asian Pac J Trop Biomed 6(8):682–685
Buhian WPC, Rubio RO, Puzon JJM (2017) Chromatographic fingerprinting and free-radical scavenging activity of ethanol extracts of Muntingia calabura L. leaves and stems. Asian Pacific Journal of Tropical Biomedicine 7(2): 139–143
Chen JJ, Lin RW, Duh CY, Huang HY, Chen IS (2004) Flavones and cytotoxic constituents from the stem bark of Muntingia calabura. J Chin Chem Soc 51:665–670
Chen JJ, Lee HH, Duh CY, Chen IS (2005) Cytotoxic chalcones and flavonoids from the leaves of Muntingia calabura. Planta Med 71:970–973
Chen JJ, Lee HH, Shih CD, Liao CH, Chen IS, Chou TH (2007) New dihydrochalcones and anti-platelet aggregation constituents from the leaves of Muntingia calabura. Planta Med 73:572–577
Einbond LS, Reynertson KA, Luo XD, Basile MJ, Kennelly EJ (2004) Anthocyanin antioxidants from edible fruits. Food Chem 84:23–28
Gomathi R, Anusuya N, Manian S (2013) A dietary antioxidant supplementation of Jamaican cherries (Muntingia calabura L.) attenuates inflammatory related disorders. Food Sci Biotechnol 22:787–794
Ibrahim IAA, Abdulla MA, Abdelwahab SI, Al-Bayaty F, Abdul Majid N (2012). Leaves extract of Muntingia calabura protects against gastric ulcer induced by ethanol in Sprague–Dawley rats. J Clin Exp Pharmacol S5:004. doi:https://doi.org/10.4172/2161-1459.S5-004. [Epub ahead of print]
Jovanovic-Malinovska R, Kuzmanova S, Winkelhausen E (2013) Oligosaccharide profile in fruits and vegetables as sources of prebiotics and functional foods. Int J Food Prop 17:949–965
Kaneda N, Pezzuto JM, Soejarto DD, Kinghorn AD, Farnsworth NR, Santisuk T, Tuchinda P, Udchachon J, Reutrakul V (1991) Plant anticancer agents, XLVIII. New cytotoxic flavanoids from Muntingia calabura roots. J Nat Prod 54:196–206
Krishnaveni M, Dhanalakshmi R (2014) Qualitative and quantitative study of phytochemicals in Muntingia Calabura L. leaf and fruit. World J Pharm Res 3(6):1687–1696
Kuo WL, Liao HR, Chen JJ (2014) Biflavans, flavonoids, and a dihydrochalcone from the stem wood of Muntingia calabura and their inhibitory activities on neutrophil pro-inflammatory responses. Molecules 19:20521–20535
Mahmood ND, Nasir NLM, Rofiee MS, Tohid SFM, Ching SM, Teh LK, Salleh MZ, Zakaria ZA (2014) Muntingia calabura: a review of its traditional uses, chemical properties, and pharmacological observations. Pharm Biol 52(12):1598–1623
Mohamad Yusof MI, Salleh MZ, Teh LK, Ahmat N, Nik Azmin NF, Zakaria ZA (2013) Activity-guided isolation of bioactive constituents with antinociceptive activity from Muntingia calabura L. leaves using the formalin test. Evid Based Complement Alternat Med 715074:1–9
Morton JF (1987) Jamaica cherry. In: Morton JF (ed) Fruits of warm climates, vol 2. Timber Press, Miami, pp 65–69
Nivethetha M, Jayasari J, Brindha P (2009) Effects of Muntingia calabura L. on isoproterenol-induced myocardial infarction. Singap Med J 50:300–302
Nshimo CM, Pezzuto JM, Kinghorn AD, Farnsworth NR (1993) Cytotoxic constituents of Muntingia calabura leaves and stems collected in Thailand. Int J Pharmacogn 31(1):77–81
Pereira GA, Arruda HS, de Morais DR, Eberlin MN, Pastore GM (2018) Carbohydrates, volatile and phenolic compounds composition and antioxidant activity of calabura (Muntingia calabura L.) fruit. Food Res Int 108:264–273
Perez-Arbealaez E (1975) In: Salazar H (ed) Plants Medicinales y Venenosas de Colombia. Medellin, Colombia, p 192
Preethi K, Vijayalakshmi N, Shamna R, Sasikumar JM (2010) In vitro antioxidant activity of extracts from fruits of Muntingia calabura Linn. from India. Pharm J 2:11–18
Preethi K, Premasudha P, Keerthana K (2012) Anti-inflammatory activity of Muntingia calabura fruits. Pharm J 4:51–56
Ragasa CY, Tan MC, Chiong ID, Shen CC (2015) Chemical constituents of Muntingia calabura L. Der Pharma Chemica 7(5):136–141
Rajesh R, Jaivel N, Marimuthu P (2014) Antifungal metabolite from Muntingia calabura root against early leaf blight of tomato. J Med Plant Res 8(17):646–656
Rotta EM, Haminiuk CWI, Maldaner L, Visentainer JV (2017) Determination of antioxidant activity and phenolic compounds of Muntingia calabura Linn. peel by HPLC-DAD and UPLC-ESI-MS/MS. Int J Food Sci Technol 52:954–963
Sani MH, Zakaria ZA, Balan T, Teh LK, Salleh MZ (2012) Antinociceptive activity of methanol extract of Muntingia calabura leaves and the mechanisms of action involved. Evid Based Complement Alternat Med 890361(1):1–10
Shih CD (2009) Activation of nitric oxide/cGMP/PKG signalling cascade mediates antihypertensive effects of Muntingia calabura in anesthetized spontaneously hypertensive rats. Am J Chin Med 37:1045–1058
Shih CD, Chen JJ, Lee HH (2006) Activation of nitric oxide signalling pathway mediates hypotensive effect of Muntingia calabura L. (Tiliaceae) leaf extract. Am J Chin Med 34:857–872
Sibi G, Naveen R, Dhananjaya K, Ravikumar KR, Mallesha H (2012) Potential use of Muntingia calabura L. extracts against human and plant pathogens. Pharm J 4:44–447
Sridhar M, Thirupathi K, Chaitanya G, Kumar BR, Mohan GK (2011) Antidiabetic effect of leaves of Muntingia calabura L., in normal and alloxan-induced diabetic rats. J Pharmacol 2:626–632
Su BN, Jung PE, Vigo JS, Graham JG, Cabieses F, Fong HH, Pezzuto JM, Kinghorn AD (2003) Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinine reductase induction assay. Phytochemistry 63:335–341
Sufian AS, Ramasamya K, Ahmat N, Zakaria Z (2013) Isolation and identification of antibacterial and cytotoxic compounds from the leaves of Muntingia calabura L. J Ethnopharmacol 146:198–204
Talalay P (2000) Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors 12:5–11
Varney J, Barrett J, Scarlata K, Catsos P, Gibson PR, Muir JG (2017) FODMAPs: food composition, defining cutoff values and international application. J Gastroenterol Hepatol 32(1):53–61
Vijayanand S, Thomas AS (2016) Screening of Michelia champacca and Muntingia calabura extracts for potential bioactives. Int J Pharma Sci Res 7:266–273
Yasunaka K, Abe F, Nagayama A, Okabe H, Lozada-Pérez L, Lopez-Villafranco E, Muñiz EE, Aguilar A, Reyes-Chilpa R (2005) Antibacterial activity of crude extracts from Mexican medicinal plants and purified coumarins and xanthones. J Ethnopharmacol 97:293–299
Yusof MM, Teh LK, Zakaria ZA, Ahmat N (2011) Antinociceptive activity of the fractionated extracts of Muntingia calabura. Planta Med 77:PF21
Zakaria ZA (2007) Free radical scavenging activity of some plants available in Malaysia. Iran J Pharmacol Ther 6:87–91
Zakaria ZA, Sulaiman MR, Jais AMM, Somchit MN, Jayaraman KV, Balakhrisnan G, Abdullah FC (2006a) The antinociceptive activity of Muntingia calabura aqueous extract and the involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its observed activity in mice. Fundam Clin Pharmacol 20:365–372
Zakaria ZA, Fatimah CA, Jais AMM, Zaiton HH, Henie EFP, Sulaiman MR, Somchit MN, Thenamutha M, Kasthuri D (2006b) The in vitro antibacterial activity of Muntingia calabura extract. J Pharmacol 2:290–293
Zakaria ZA, Kumar GH, Zaid SNH, Ghani MA, Hassan MH, Hazalin NAMN, Khamis MM, Devi GR, Sulaiman MR (2007a) Analgesic and antipyretic actions of Muntingia calabura leaves chloroform extract in animal models. Orient Pharm Exp Med 7:34–40
Zakaria ZA, Jais AMM, Mastura M, Mat Jusoh SH, Mohamed AM, Mohd Jamil NS, Rofiee MS, Sulaiman MR (2007b) In vitro antistaphylococcal activity of the extracts of several neglected plants in Malaysia. Int J Pharmacol 3:428–431
Zakaria ZA, Hassan MH, Aqmar NMNH, Abd Ghani M, Mohd Zaid SN, Sulaiman MR, Hanan Kumar G, Fatimah CA (2007c) Effects of various nonopioid receptor antagonists on the antinociceptive activity of Muntingia calabura extracts in mice. Methods Find Exp Clin Pharmacol 29:515–520
Zakaria ZA, Mustapha S, Sulaiman MR, Mat Jais AM, Somchit MN, Abdullah FC (2007d) The antinociceptive action of aqueous extract from Muntingia calabura leaves: the role of opioid receptors. Med Princ Pract 16:130–136
Zakaria ZA, Hazalin NAMN, Zaid SNHM, Abdul Ghani M, Hassan MH, Gopalan HK, Sulaiman MR (2007e) Antinociceptive, anti-inflammatory and antipyretic effects of Muntingia calabura aqueous extract in animal models. J Nat Med 61:443–448
Zakaria ZA, Somchit MN, Sulaiman MR, Jais AMM, Fatimah CA (2008) Effects of various receptor antagonists, pH and enzymes on Muntingia calabura antinociception in mice. Res J Pharmacol 2:31–37
Zakaria ZZ, Sufian AS, Ramasamy K, Ahmat N, Sulaiman MR, Abdul KA, Ahmad Z, Abdullah MNH (2010) In vitro antimicrobial activity of Muntingia calabura extracts and fractions. Afr J Microbiol Res 4(4):304–308
Zakaria ZA, Mohamed AM, Jamil NS, Rofiee MS, Hussain MK, Sulaiman MR, Teh LK, Salleh MZ (2011) In vitro antiproliferative and antioxidant activities of the extracts of Muntingia calabura leaves. Am J Chin Med 39:1–18
Zakaria ZA, Mohd Sani MH, Cheema MS, Abdul Kader A, Teh LK, Salleh MZ (2014) Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms. J Int Soc Complement Med Res 14:63–75
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Mastuki, S.N., Faudzi, S.M.M., Ismail, N., Saad, N. (2019). Muntingia calabura: Chemical Composition, Bioactive Component and Traditional Uses. In: Mariod, A. (eds) Wild Fruits: Composition, Nutritional Value and Products. Springer, Cham. https://doi.org/10.1007/978-3-030-31885-7_41
Download citation
DOI: https://doi.org/10.1007/978-3-030-31885-7_41
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-31884-0
Online ISBN: 978-3-030-31885-7
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)