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Emerging Research in Science and Engineering Based on Advanced Experimental and Computational Strategies pp 305–338Cite as

Pharmacophore Mapping of Natural Products for Pancreatic Lipase Inhibition

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Abstract

The use of pancreatic lipase (LP) inhibitors to reduce the absorption of dietary fats has become one of the pharmacological approaches adopted for the treatment of obesity. Since natural products continue to play a significant role in drug discovery and development the search for natural compounds with PL inhibitory activity is an interesting approach to provide new lead compounds for drug discovery and to guide dietary trends in order to prevent or treat obesity. The consumption of Myrciaria genus plant species is also related to increased HDL cholesterol and improved triglycerides excretion in animal models. In addition, extracts of species from Myrciaria genus are related to in vitro inhibitory activity against PL. Hence it is important to identify which chemical markers from Myrciaria genus species are structurally related to PL inhibitory activity. Ligand-based pharmacophore modeling is one of the most applied approaches in medicinal chemistry in order to detect molecular features related to molecules that are able to modulate a particular biological target. Some Myrciaria genus chemical markers including polyphenols, glycosides and lactonic derivatives share molecular features found in classic PL inhibitors. Such phytomolecules from Myrciaria species are a starting point to develop novel therapeutic options for obesity with PL inhibitory activity.

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Authors and Affiliations

  1. Laboratório de Pesquisa em Produtos Naturais (LPPN), Faculdade de Farmácia, Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brazil

    Matheus Gabriel de Oliveira & Waléria Ramos Nogueira de Souza

  2. Graduate Program in Pharmaceutical Sciences, Federal University of Espirito Santo (UFES), Vitória, Espírito Santo, Brazil

    Ricardo Pereira Rodrigues

  3. Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil

    Daniel F. Kawano

  4. Escola de Ciências Médicas, Farmacêuticas e Biomédicas, Pontifícia Universidade Estadual de Goiás, Anápolis, Goiás, Brazil

    Leonardo Luiz Borges & Vinicius Barreto da Silva

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    Felipe de Almeida La Porta

  2. Centro Brasileiro de Pesquisas Físicas, Rio de Janeiro, Brazil

    Carlton A. Taft

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de Oliveira, M.G., de Souza, W.R.N., Rodrigues, R.P., Kawano, D.F., Borges, L.L., da Silva, V.B. (2020). Pharmacophore Mapping of Natural Products for Pancreatic Lipase Inhibition. In: La Porta, F., Taft, C. (eds) Emerging Research in Science and Engineering Based on Advanced Experimental and Computational Strategies. Engineering Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-31403-3_12

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