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Neural Stem Cells

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Stem Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1201))

Abstract

Neural stem cell (NSC) transplantation has provided the basis for the development of potentially powerful new therapeutic cell-based strategies for a broad spectrum of clinical diseases, including stroke, psychiatric illnesses such as fetal alcohol spectrum disorders, and cancer. Here, we discuss pertinent preclinical investigations involving NSCs, including how NSCs can ameliorate these diseases, the current barriers hindering NSC-based treatments, and future directions for NSC research. There are still many translational requirements to overcome before clinical therapeutic applications, such as establishing optimal dosing, route of delivery, and timing regimens and understanding the exact mechanism by which transplanted NSCs lead to enhanced recovery. Such critical lab-to-clinic investigations will be necessary in order to refine NSC-based therapies for debilitating human disorders.

Julian P. Tuazon and Vanessa Castelli contributed equally to this manuscript.

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    Authors and Affiliations

    1. Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA

      Julian P. Tuazon, Vanessa Castelli, Jea-Young Lee & Cesar V. Borlongan

    2. Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

      Giovambattista B. Desideri & Anna Maria Cimini

    3. Department of Psychological, Humanistic and Territorial Sciences, University G. D’Annunzio, Chieti, Italy

      Liborio Stuppia

    4. Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Philadelphia, PA, USA

      Anna Maria Cimini

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    1. Julian P. Tuazon
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    Correspondence to Cesar V. Borlongan .

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    1. Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

      Mariusz Z. Ratajczak

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    Tuazon, J.P. et al. (2019). Neural Stem Cells. In: Ratajczak, M. (eds) Stem Cells. Advances in Experimental Medicine and Biology, vol 1201. Springer, Cham. https://doi.org/10.1007/978-3-030-31206-0_4

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