Abstract
Repair and regeneration of cartilage tissue has always posed difficulties owing to its avascular, aneural structure and its sparsely distributed cellular arrangement within a dense extracellular matrix. This is why damage to cartilage tissue such as acute trauma, repetitive trauma, inflammatory disease, or wear due to aging eventually results in osteoarthritis. In addition to being a challenging disease for both patients and physicians, osteoarthritis is also a significant public health issue that requires the attention of healthcare planners. In the osteochondral tissue damage, it is important to provide a tissue scaffold and support biosignaling molecules due to its dense extracellular structure as well as cell-based treatments. Therefore, the importance of nanomaterials in tissue regeneration studies is gradually increasing. Nanomaterials are defined as structural elements smaller than 100 nm in at least one dimension, and they offer us the ability to control various properties of materials by assembling them at nanometric proportions. With their excellent biomimetic and physicochemical properties, nanomaterials open up new possibilities and horizons as integration, interaction and signaling in structural and cellular dimensions. This chapter will discuss the opportunities provided by nanomaterials in cartilage regeneration.
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Ozkan, H., Yanmis, O. (2019). Nanomaterials for Cartilage Regeneration. In: Tekinay, A. (eds) Nanomaterials for Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana, Cham. https://doi.org/10.1007/978-3-030-31202-2_6
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DOI: https://doi.org/10.1007/978-3-030-31202-2_6
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