Abstract
Repair and regeneration of cartilage tissue has always posed difficulties owing to its avascular, aneural structure and its sparsely distributed cellular arrangement within a dense extracellular matrix. This is why damage to cartilage tissue such as acute trauma, repetitive trauma, inflammatory disease, or wear due to aging eventually results in osteoarthritis. In addition to being a challenging disease for both patients and physicians, osteoarthritis is also a significant public health issue that requires the attention of healthcare planners. In the osteochondral tissue damage, it is important to provide a tissue scaffold and support biosignaling molecules due to its dense extracellular structure as well as cell-based treatments. Therefore, the importance of nanomaterials in tissue regeneration studies is gradually increasing. Nanomaterials are defined as structural elements smaller than 100 nm in at least one dimension, and they offer us the ability to control various properties of materials by assembling them at nanometric proportions. With their excellent biomimetic and physicochemical properties, nanomaterials open up new possibilities and horizons as integration, interaction and signaling in structural and cellular dimensions. This chapter will discuss the opportunities provided by nanomaterials in cartilage regeneration.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Armiento, A. R., Stoddart, M. J., Alini, M., & Eglin, D. (2018). Biomaterials for articular cartilage tissue engineering: Learning from biology. Acta Biomaterialia, 65, 1–20. https://doi.org/10.1016/j.actbio.2017.11.021
Arslan, E., Sardan Ekiz, M., Eren Cimenci, C., Can, N., Gemci, M. H., Ozkan, H., … Tekinay, A. B. (2018). Protective therapeutic effects of peptide nanofiber and hyaluronic acid hybrid membrane in in vivo osteoarthritis model. Acta Biomaterialia, 73, 263–274. https://doi.org/10.1016/j.actbio.2018.04.015
Bhosale, A. M., & Richardson, J. B. (2008). Articular cartilage: Structure, injuries and review of management. British Medical Bulletin, 87, 77–95. https://doi.org/10.1093/bmb/ldn025
Brown, S., Kumar, S., & Sharma, B. (2019). Intra-articular targeting of nanomaterials for the treatment of osteoarthritis. Acta Biomaterialia, 93, 239–257. https://doi.org/10.1016/j.actbio.2019.03.010
Camarero-Espinosa, S., Rothen-Rutishauser, B., Foster, E. J., & Weder, C. (2016). Articular cartilage: From formation to tissue engineering. Biomaterials Science, 4, 734–767. https://doi.org/10.1039/c6bm00068a
Chahine, N. O., Collette, N. M., Thomas, C. B., Genetos, D. C., & Loots, G. G. (2014). Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: Effects of carbon nanotube surface functionalization. Tissue Engineering Part A, 20(17–18), 2305–2315. https://doi.org/10.1089/ten.tea.2013.0328
Chen, H., Zeng, Y., Liu, W., Zhao, S., Wu, J., & Du, Y. (2013). Multifaceted applications of nanomaterials in cell engineering and therapy. Biotechnology Advances, 31, 638. https://doi.org/10.1016/j.biotechadv.2012.08.002
Chen, M. J., Whiteley, J. P., Please, C. P., Ehlicke, F., Waters, S. L., & Byrne, H. M. (2019). Identifying chondrogenesis strategies for tissue engineering of articular cartilage. Journal of Tissue Engineering, 10, 2041731419842431. https://doi.org/10.1177/2041731419842431
Erisken, C., Kalyon, D. M., Wang, H., Örnek-Ballanco, C., & Xu, J. (2011). Osteochondral tissue formation through adipose-derived stromal cell differentiation on biomimetic polycaprolactone nanofibrous scaffolds with graded insulin and beta-glycerophosphate concentrations. Tissue Engineering Part A, 17(9–10), 1239–1252. https://doi.org/10.1089/ten.tea.2009.0693
Eslahi, N., Abdorahim, M., & Simchi, A. (2016). Smart polymeric hydrogels for cartilage tissue engineering: A review on the chemistry and biological functions. Biomacromolecules, 17, 3441–3463. https://doi.org/10.1021/acs.biomac.6b01235
Etkin, C. D., & Springer, B. D. (2017). The American Joint Replacement Registry—The first 5 years. Arthroplasty Today, 3(2), 67–69. https://doi.org/10.1016/j.artd.2017.02.002
Goldring, M. B. (2012). Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Therapeutic Advances in Musculoskeletal Disease, 4(4), 269–285. https://doi.org/10.1177/1759720X12448454
Goldring, S. R., & Goldring, M. B. (2016). Changes in the osteochondral unit during osteoarthritis: Structure, function and cartilage bone crosstalk. Nature Reviews Rheumatology, 12, 632–644. https://doi.org/10.1038/nrrheum.2016.148
Herneisey, M., Williams, J., Mirtic, J., Liu, L., Potdar, S., Bagia, C., … Janjic, J. M. (2016). Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents. Therapeutic Delivery, 7(12), 795–808. https://doi.org/10.4155/tde-2016-0050
Hunziker, E. B., Quinn, T. M., & Häuselmann, H. J. (2002). Quantitative structural organization of normal adult human articular cartilage. Osteoarthritis and Cartilage, 10(7), 564–572. https://doi.org/10.1053/joca.2002.0814
Karami, P., Wyss, C. S., Khoushabi, A., Schmocker, A., Broome, M., Moser, C., … Pioletti, D. P. (2018). Composite double-network hydrogels to improve adhesion on biological surfaces. ACS Applied Materials and Interfaces, 10(45), 38692–38699. https://doi.org/10.1021/acsami.8b10735
Kwon, H., Brown, W. E., Lee, C. A., Wang, D., Paschos, N., Hu, J. C., & Athanasiou, K. A. (2019). Surgical and tissue engineering strategies for articular cartilage and meniscus repair. Nature Reviews Rheumatology, 15, 550. https://doi.org/10.1038/s41584-019-0255-1
Li, J., Chen, G., Xu, X., Abdou, P., Jiang, Q., Shi, D., & Gu, Z. (2019). Advances of injectable hydrogel-based scaffolds for cartilage regeneration. Regenerative Biomaterials, 6(3), 129–140. https://doi.org/10.1093/rb/rbz022
Li, T., Chubinskaya, S., Esposito, A., Jin, X., Tagliafierro, L., Loeser, R., … Spagnoli, A. (2019). TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. Science Translational Medicine, 11(491), eaan2585. https://doi.org/10.1126/scitranslmed.aan2585
Li, T., Longobardi, L., Myers, T. J., Temple, J. D., Chandler, R. L., Ozkan, H., … Spagnoli, A. (2012). Joint TGF-β type II receptor-expressing cells: Ontogeny and characterization as joint progenitors. Stem Cells and Development, 22(9), 1342–1359. https://doi.org/10.1089/scd.2012.0207
Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012). Osteoarthritis: A disease of the joint as an organ. Arthritis and Rheumatism, 64, 1697–1707. https://doi.org/10.1002/art.34453
Longobardi, L., Li, T., Myers, T. J., O’Rear, L., Ozkan, H., Li, Y., … Spagnoli, A. (2012). TGF-β type II receptor/MCP-5 axis: At the crossroad between joint and growth plate development. Developmental Cell, 23(1), 71–81. https://doi.org/10.1016/j.devcel.2012.05.004
Mahboudi, H., Kazemi, B., Soleimani, M., Hanaee-Ahvaz, H., Ghanbarian, H., Bandehpour, M., … Barati, G. (2018). Enhanced chondrogenesis of human bone marrow mesenchymal Stem Cell (BMSC) on nanofiber-based polyethersulfone (PES) scaffold. Gene, 643, 98–106. https://doi.org/10.1016/j.gene.2017.11.073
Manoukian, O. S., Dieck, C., Milne, T., Dealy, C. N., Rudraiah, S., & Kumbar, S. G. (2018). Nanomaterials/nanocomposites for osteochondral tissue. Advances in Experimental Medicine and Biology, 1058, 79–95. https://doi.org/10.1007/978-3-319-76711-6_4
Martel-Pelletier, J., Barr, A. J., Cicuttini, F. M., Conaghan, P. G., Cooper, C., Goldring, M. B., … Pelletier, J.-P. (2016). Osteoarhritis. Nature Reviews. Disease Primers, 13(2), 16702.
Medvedeva, E. V., Grebenik, E. A., Gornostaeva, S. N., Telpuhov, V. I., Lychagin, A. V., Timashev, P. S., & Chagin, A. S. (2018). Repair of damaged articular cartilage: Current approaches and future directions. International Journal of Molecular Sciences, 19, E2366. https://doi.org/10.3390/ijms19082366
Patel, S. K., Beaino, W., Anderson, C. J., & Janjic, J. M. (2015). Theranostic nanoemulsions for macrophage COX-2 inhibition in a murine inflammation model. Clinical Immunology, 160(1), 59–70. https://doi.org/10.1016/j.clim.2015.04.019
Ribeiro, V. P., Pina, S., Costa, J. B., Cengiz, I. F., García-Fernández, L., Fernández-Gutiérrez, M. D. M., … Reis, R. L. (2019). Enzymatically cross-linked silk fibroin-based hierarchical scaffolds for osteochondral regeneration. ACS Applied Materials and Interfaces, 11(4), 3781–3799. https://doi.org/10.1021/acsami.8b21259
Santo, V. E., Gomes, M. E., Mano, J. F., & Reis, R. L. (2012). From nano-to macro-scale: Nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering. Nanomedicine, 7, 1045–1066. https://doi.org/10.2217/nnm.12.78
Simon, T. M., & Jackson, D. W. (2018). Articular cartilage: Injury pathways and treatment options. Sports Medicine and Arthroscopy Review, 26, 146–154. https://doi.org/10.1097/JSA.0000000000000182
Spagnoli, A., O’Rear, L., Chandler, R. L., Granero-Molto, F., Mortlock, D. P., Gorska, A. E., … Moses, H. L. (2007). TGF-β signaling is essential for joint morphogenesis. Journal of Cell Biology, 177(6), 1105–1117. https://doi.org/10.1083/jcb.200611031
Vinatier, C., & Guicheux, J. (2016). Cartilage tissue engineering: From biomaterials and stem cells to osteoarthritis treatments. Annals of Physical and Rehabilitation Medicine, 59, 139–144. https://doi.org/10.1016/j.rehab.2016.03.002
Wang, S., Wei, X., Sun, X., Chen, C., Zhou, J., Zhang, G., … Wei, L. (2018). A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system. International Journal of Nanomedicine, 13, 617–631. https://doi.org/10.2147/IJN.S142797
Yaylaci, S. U., Sen, M., Bulut, O., Arslan, E., Guler, M. O., & Tekinay, A. B. (2016). Chondrogenic differentiation of mesenchymal stem cells on glycosaminoglycan-mimetic peptide nanofibers. ACS Biomaterials Science & Engineering, 2(5), 871–878. https://doi.org/10.1021/acsbiomaterials.6b00099
Yu, F., Li, M., Yuan, Z., Rao, F., Fang, X., Jiang, B., … Zhang, P. (2018). Mechanism research on a bioactive resveratrol–PLA–gelatin porous nano-scaffold in promoting the repair of cartilage defect. International Journal of Nanomedicine, 13, 7845–7858. https://doi.org/10.2147/IJN.S181855
Zhang, L., Hu, J., & Athanasiou, K. A. (2012). The role of tissue engineering in articular cartilage repair and regeneration. Critical Reviews in Biomedical Engineering, 37(1–2), 1–57. https://doi.org/10.1615/critrevbiomedeng.v37.i1-2.10
Zhou, Y., Chyu, J., & Zumwalt, M. (2018). Recent progress of fabrication of cell scaffold by electrospinning technique for articular cartilage tissue engineering. International Journal of Biomaterials, 2018, 1953636. https://doi.org/10.1155/2018/1953636
Zylińska, B., Silmanowicz, P., Sobczyńska-Rak, A., Jarosz, Ł., & Szponder, T. (2018). Treatment of articular cartilage defects: Focus on tissue engineering. In Vivo, 32, 1289–1300. https://doi.org/10.21873/invivo.11379
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Ozkan, H., Yanmis, O. (2019). Nanomaterials for Cartilage Regeneration. In: Tekinay, A. (eds) Nanomaterials for Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana, Cham. https://doi.org/10.1007/978-3-030-31202-2_6
Download citation
DOI: https://doi.org/10.1007/978-3-030-31202-2_6
Published:
Publisher Name: Humana, Cham
Print ISBN: 978-3-030-31201-5
Online ISBN: 978-3-030-31202-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)