Abstract
As one of the rare tissues where cell proliferation can be severely problematic, neural tissue damages due to accidents or diseases remain one of the major challenges in medicine. Neural tissue engineering offers great revolution in repairing neural injuries. Guidance for neurite extension and connectivity are considered as primary factors in designing neural scaffolds. Several types of nanomaterials have been proposed to be used for therapeutic purposes for neural regeneration. Among these materials electrospun nanofibers made of polymeric and natural biomaterials and self-assembled peptide/peptide amphiphile nanofibers are the most widely studied examples. Electrospinning is a versatile method in fabrication of nanofibers and garnering endless attention among various scientific disciplines including biomedical sciences for their potential use. The scaffolds made of electrospun nanofibers offer excellent environment for cell adhesion and proliferation that opens new avenue in the tissue regeneration application. Natural biomaterials, on the other hand, offer inherent biocompatibility and bioactivity, both of which are desirable qualities for biomaterials for neuroregeneration. Self-assembled peptide nanofibers are also quite advantageous nanomaterials with well-defined chemical structures, low immunogenicity, tailorable bioactivity, and inherent biocompatibility. Advancements in fabrication of neural scaffolds using abovementioned techniques have shed light on neural regeneration research into a new era as it offers the fabrication of tunable and diverse range of scaffolds. In this chapter, we briefly present nanotherapeutics that have been developed for neural regeneration and examples of various nanomaterials and their fabrication methods.
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Tekinay, A.B., Balusamy, B., Senthamizhan, A., Uyar, T. (2019). Neuroregenerative Nanotherapeutics. In: Tekinay, A. (eds) Nanomaterials for Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana, Cham. https://doi.org/10.1007/978-3-030-31202-2_5
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