Abstract
In the current research, an optimization design strategy for additive manufacturing processes based on extrusion/injection methods was extended to the fabrication of poly(ε-caprolactone) (PCL)/iron oxide (Fe3O4) scaffolds for tissue engineering. The attention was focused on four parameters: process temperature (PT), deposition velocity (DV), screw rotation velocity (SRV), slice thickness (ST). Specifically, PCL/Fe3O4 scaffolds were manufactured varying iteratively one parameter, while maintaining constant the other three parameters. A further insight into the influence of process parameters on the morphological features and mechanical properties of PCL/Fe3O4 scaffolds was provided.
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References
Rijal, N.P., Adhikari, U., Khanal, S., Pai, D., Sankar, J., Bhattarai, N.: Magnesium oxide poly(ε-caprolactone)-chitosan-based composite nanofiber for tissue engineering applications. Mater. Sci. Eng., B 228, 18–27 (2018)
Inzana, J.A., Olvera, D., Fuller, S.M., Kelly, J.P., Graeve, O.A., Schwarz, E.M., Kates, S.L., Awad, H.A.: 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35, 4026–4034 (2014)
Costa-Pinto, A.R., Reis, R.L., Neves, N.M.: Scaffolds based bone tissue engineering: the role of chitosan. Tissue Eng. Part B Rev. 17, 331–347 (2011)
Hollister, S.J.: Porous scaffold design for tissue engineering. Nat. Mater. 4, 518–524 (2005)
Ng, K.W., Hutmacher, D.W., Schantz, J.T., Ng, C.S., Too, H.P., Lim, T.C., Phan, T.T., Teoh, S.H.: Evaluation of ultra-thin poly(ε-caprolactone) films for tissue-engineered skin. Tissue Eng. 7, 441–455 (2011)
Moroni, L., de Wijn, J.R., van Blitterswijk, C.A.: Three-dimensional fiber-deposited PEOT/PBT copolymer scaffolds for tissue engineering: influence of porosity, molecular network mesh size and swelling in aqueous media on dynamic mechanical properties. J. Biomed. Mater. Res. A 75, 957–965 (2005)
De Santis, R., D’Amora, U., Russo, T., Ronca, A., Gloria, A., Ambrosio, L.: 3D fibre deposition and stereolithography techniques for the design of multifunctional nanocomposite magnetic scaffolds. J. Mater. Sci. Mater. Med. 26, 250 (2015)
Martorelli, M., Ausiello, P., Morrone, R.: A new method to assess the accuracy of a cone beam computed tomography scanner by using a non-contact reverse engineering technique. J. Dent. 42(4), 460–465 (2014)
Giordano, M., Ausiello, P., Martorelli, M., Sorrentino, R.: Reliability of computer designed surgical guides in six implant rehabilitations with two years follow-up. Dental. Mater. 28(9), e168–e177 (2012)
Ausiello, P., Ciaramella, S., Fabianelli, A., Gloria, A., Martorelli, M., Lanzotti, A., Watts, D.C.: Mechanical behavior of bulk direct composite versus block composite and lithium disilicate indirect Class II restorations by CAD-FEM modeling. Dent. Mater. 33(6), 690–701 (2017)
De Santis, R., Gloria, A., Maietta, S., Martorelli, M., De Luca, A., Spagnuolo, G., Riccitiello, F., Rengo, S.: Mechanical and thermal properties of dental composites cured with CAD/CAM assisted solid-state laser. Materials 11, 504 (2018)
Sun, H., Zhu, F., Hu, Q., Krebsbach, P.H.: Controlling stem cell-mediated bone regeneration through tailored mechanical properties of collagen scaffolds. Biomaterials 35, 1176–1184 (2014)
De Santis, R., Russo, A., Gloria, A., D’Amora, U., Russo, T., Panseri, S., Sandri, M., Tampieri, A., Marcacci, M., Dediu, V.A., Wilde, C.J., Ambrosio, L.: Towards the design of 3D fiber-deposited poly(ε-caprolactone)/iron-doped hydroxyapatite nanocomposite magnetic scaffolds for bone regeneration. J. Biomed. Nanotechnol. 11(7), 1236–1246 (2015)
Xiaolan, B., Hadjiargyrou, M., Di Masi, E., Meng, Y., Simon, M., Tan, Z., Rafailovich, M.H.: The role of moderate static magnetic fields on biomineralization of osteoblasts on sulfonated polystyrene films. Biomaterials 32, 7831–7838 (2011)
Ross, S.M.: Combined DC and ELF magnetic fields can alter cell proliferation. Bioelectromagnetics 11, 27–36 (1990)
Hashimoto, Y., Kawasumi, M., Saito, M.: Effect of static magnetic field on cell migration. Electr. Eng. Jpn. 160, 46–52 (2007)
Kotani, H., Kawaguchi, H., Shimaoka, T., Iwasaka, M., Ueno, S., Ozawa, H., Nakamura, K., Hoshi, K.: Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. J. Bone Min. Res. 17, 1814–1821 (2002)
De Santis, R., Gloria, A., Russo, T., D’Amora, U., Zeppetelli, S., Tampieri, A., Herrmannsdörfer, T., Ambrosio, L.: A route toward the development of 3D magnetic scaffolds with tailored mechanical and morphological properties for hard tissue regeneration: Preliminary study. Virtual Phys. Prototyp. 6(4), 189–195 (2011)
Domingos, M., Chiellini, F., Gloria, A., Ambrosio, L., Bartolo, P., Chiellini, E.: Effect of process parameters on the morphological and mechanical properties of 3D Bioextruded poly(ε-caprolactone) scaffolds. Rapid Prototyp. J. 18, 56–67 (2012)
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Gloria, A., Domingos, M., Maietta, S., Martorelli, M., Lanzotti, A. (2020). Optimization Design Strategy for Additive Manufacturing Process to Develop 3D Magnetic Nanocomposite Scaffolds. In: Rizzi, C., Andrisano, A.O., Leali, F., Gherardini, F., Pini, F., Vergnano, A. (eds) Design Tools and Methods in Industrial Engineering. ADM 2019. Lecture Notes in Mechanical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-030-31154-4_81
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DOI: https://doi.org/10.1007/978-3-030-31154-4_81
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