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Cancer Immunology pp 107–116Cite as

T-Cell Metabolism and Its Dysfunction Induced by Cancer

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Abstract

This chapter is focused on the changes in the metabolic pathways of immune cells to fulfill the demands of development, proliferation, and effector function of T-cells.

We review how T-cells change their metabolism to (a) obtain energy throughout the different states of maturation (naive, memory, and effector cell), (b) form construction blocks to proliferate (carbon skeleton and nitrogen for nitrogen bases), and (c) live during a long-term period. Finally, we also review how the metabolism of T-cell is affected by the tumor microenvironment.

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Acknowledgements

This work was supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT), grant CB-2013-219932.

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Authors and Affiliations

  1. Departamento de Enfermedades Cronico-Degenerativas, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico

    Heriberto Prado-Garcia, Rosa Sandoval-Martinez & Susana Romero-Garcia

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  1. Heriberto Prado-Garcia
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  2. Rosa Sandoval-Martinez
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  3. Susana Romero-Garcia
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Editors and Affiliations

  1. Research Center for Immunodeficiencies, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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Prado-Garcia, H., Sandoval-Martinez, R., Romero-Garcia, S. (2020). T-Cell Metabolism and Its Dysfunction Induced by Cancer. In: Rezaei, N. (eds) Cancer Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-30845-2_7

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  • DOI: https://doi.org/10.1007/978-3-030-30845-2_7

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