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Epidemiology of Occupational Lung Cancer

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Abstract

Occupational risk factors constitute a significant factor for lung cancer risk. The risk of lung cancer is especially increased among workers employed in a number of industries and occupations such as mining, construction, metalworking, and driving. The attributable fraction for lung cancer risk from occupational exposures is reported to be higher in men and an interaction with smoking may occur. Significant occupational carcinogens include asbestos, polycyclic aromatic hydrocarbons including diesel engine emissions, crystalline silica, and some heavy metals. While the burden of occupational lung cancer might have decreased in recent decades, preventive efforts are still needed to further reduce the carcinogenic effects of these exposures.

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References

  1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.

    Article  CAS  PubMed  Google Scholar 

  2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90.

    Article  PubMed  Google Scholar 

  3. Ezzati M, Lopez AD. Estimates of global mortality attributable to smoking in 2000. Lancet. 2003;362(9387):847–52.

    Article  PubMed  Google Scholar 

  4. Tyczynski JE, Bray F, Parkin DM. Lung cancer in Europe in 2000: epidemiology, prevention, and early detection. Lancet Oncol. 2003;4(1):45–55.

    Article  PubMed  Google Scholar 

  5. Spyratos D, Zarogoulidis P, Porpodis K, Tsakiridis K, Machairiotis N, Katsikogiannis N, Kougioumtzi I, Dryllis G, Kallianos A, Rapti A, Li C, Zarogoulidis K. Occupational exposure and lung cancer. J Thorac Dis. 2013;5(Suppl 4):S440–5.

    PubMed  PubMed Central  Google Scholar 

  6. Rushton L, Hutchings SJ, Fortunato L, Young C, Evans GS, Brown T, Bevan R, Slack R, Holmes P, Bagga S, Cherrie JW, Van Tongeren M. Occupational cancer burden in Great Britain. Br J Cancer. 2012;107(Suppl 1):S3–7.

    Article  PubMed  PubMed Central  Google Scholar 

  7. De Matteis S, Consonni D, Lubin JH, Tucker M, Peters S, Vermeulen R, Kromhout H, Bertazzi PA, Caporaso NE, Pesatori AC, Wacholder S, Landi MT. Impact of occupational carcinogens on lung cancer risk in a general population. Int J Epidemiol. 2012;41(3):711–21.

    Article  PubMed  PubMed Central  Google Scholar 

  8. IARC. Man-made vitreous fibres. IARC Monogr Eval Carcinog Risks Hum. 2002;81:1–381.

    Google Scholar 

  9. Boffetta P, E. Harris R, L. Wynder E. Diesel exhaust exposure and lung cancer risk. Exp Pathol. 1989;37(1-4):32–8.

    Article  CAS  PubMed  Google Scholar 

  10. Neuberger JS, Field RW. Occupation and lung cancer in nonsmokers. Rev Environ Health. 2003;18(4):251–67.

    Article  PubMed  Google Scholar 

  11. Burns PB, Swanson GM. The occupational cancer incidence surveillance study (OCISS): risk of lung cancer by usual occupation and industry in the Detroit metropolitan area. Am J Ind Med. 1991;19(5):655–71.

    Article  CAS  PubMed  Google Scholar 

  12. Bardin-Mikolajczak A, Lissowska J, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Fabianova E, Mates D, Navratilova M, Bencko V, Janout V, Fevotte J, Fletcher T, t Mannetje A, Brennan P, Boffetta P. Occupation and risk of lung cancer in Central and Eastern Europe: the IARC multi-center case-control study. Cancer Causes Control. 2007;18(6):645–54.

    Article  PubMed  Google Scholar 

  13. Jarvholm B. Carcinogens in the construction industry. Ann N Y Acad Sci. 2006;1076:421–8.

    Article  PubMed  Google Scholar 

  14. Rushton L, Hutchings S, Brown T. The burden of cancer at work: estimation as the first step to prevention. Occup Environ Med. 2008;65(12):789–800.

    Article  CAS  PubMed  Google Scholar 

  15. Boffetta P. Epidemiology of environmental and occupational cancer. Oncogene. 2004;23(38):6392–403.

    Article  CAS  PubMed  Google Scholar 

  16. Berman DW, Crump KS. Update of potency factors for asbestos-related lung cancer and mesothelioma. Crit Rev Toxicol. 2008;38(Suppl 1):1–47.

    Article  CAS  PubMed  Google Scholar 

  17. IARC. IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: asbestos. IARC Monogr Eval Carcinog Risk Chem Man. 1977;14:1–106.

    Google Scholar 

  18. Wolff H, Vehmas T, Oksa P, Rantanen J, Vainio H. Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations. Scand J Work Environ Health. 2015;41(1):5–15.

    Article  PubMed  Google Scholar 

  19. Liddell FD. The interaction of asbestos and smoking in lung cancer. Ann Occup Hyg. 2001;45(5):341–56.

    Article  CAS  PubMed  Google Scholar 

  20. Olsson AC, Vermeulen R, Schuz J, Kromhout H, Pesch B, Peters S, Behrens T, Portengen L, Mirabelli D, Gustavsson P, Kendzia B, Almansa J, Luzon V, Vlaanderen J, Stucker I, Guida F, Consonni D, Caporaso N, Landi MT, Field J, Bruske I, Wichmann HE, Siemiatycki J, Parent ME, Richiardi L, Merletti F, Jockel KH, Ahrens W, Pohlabeln H, Plato N, Tardon A, Zaridze D, McLaughlin J, Demers P, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Stanescu Dumitru R, Bencko V, Foretova L, Janout V, Boffetta P, Bueno-de-Mesquita B, Forastiere F, Bruning T, Straif K. Exposure-response analyses of asbestos and lung cancer subtypes in a pooled analysis of case-control studies. Epidemiology. 2017;28(2):288–99.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Pintos J, Parent ME, Rousseau MC, Case BW, Siemiatycki J. Occupational exposure to asbestos and man-made vitreous fibers, and risk of lung cancer: evidence from two case-control studies in Montreal, Canada. J Occup Environ Med. 2008;50(11):1273–81.

    Article  PubMed  Google Scholar 

  22. Hayes RB. The carcinogenicity of metals in humans. Cancer Causes Control. 1997;8(3):371–85.

    Article  CAS  PubMed  Google Scholar 

  23. IARC. Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry. Working Group views and expert opinions, Lyon, 9-16 February 1993. IARC Monogr Eval Carcinog Risks Hum. 1993;58:1–415.

    Google Scholar 

  24. Boffetta P, Fryzek JP, Mandel JS. Occupational exposure to beryllium and cancer risk: a review of the epidemiologic evidence. Crit Rev Toxicol. 2012;42(2):107–18.

    Article  CAS  PubMed  Google Scholar 

  25. Wong JYY, Bassig BA, Seow WJ, Hu W, Ji BT, Blair A, Silverman DT, Lan Q. Lung cancer risk in welders and foundry workers with a history of heavy smoking in the USA: The National Lung Screening Trial. Occup Environ Med. 2017;74(6):440–8.

    Article  PubMed  Google Scholar 

  26. Vallieres E, Pintos J, Lavoue J, Parent ME, Rachet B, Siemiatycki J. Exposure to welding fumes increases lung cancer risk among light smokers but not among heavy smokers: evidence from two case-control studies in Montreal. Cancer Med. 2012;1(1):47–58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. t Mannetje A, Brennan P, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Fabianova E, Cassidy A, Mates D, Bencko V, Foretova L, Janout V, Fevotte J, Fletcher T, Boffetta P. Welding and lung cancer in Central and Eastern Europe and the United Kingdom. Am J Epidemiol. 2012;175(7):706–14.

    Article  Google Scholar 

  28. IARC. Chromium, nickel and welding. IARC Monogr Eval Carcinog Risks Hum. 1990;49:1–648.

    Google Scholar 

  29. Kauppinen T, Toikkanen J, Pedersen D, Young R, Ahrens W, Boffetta P, Hansen J, Kromhout H, Maqueda Blasco J, Mirabelli D, de la Orden-Rivera V, Pannett B, Plato N, Savela A, Vincent R, Kogevinas M. Occupational exposure to carcinogens in the European Union. Occup Environ Med. 2000;57(1):10–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Steenland K, Stayner L. Silica, asbestos, man-made mineral fibers, and cancer. Cancer Causes Control. 1997;8(3):491–503.

    Article  CAS  PubMed  Google Scholar 

  31. Steenland K, Mannetje A, Boffetta P, Stayner L, Attfield M, Chen J, Dosemeci M, DeKlerk N, Hnizdo E, Koskela R, Checkoway H, C. International Agency for Research on. Pooled exposure-response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study. Cancer Causes Control. 2001;12(9):773–84.

    Article  CAS  PubMed  Google Scholar 

  32. Vida S, Pintos J, Parent ME, Lavoue J, Siemiatycki J. Occupational exposure to silica and lung cancer: pooled analysis of two case-control studies in Montreal, Canada. Cancer Epidemiol Biomarkers Prev. 2010;19(6):1602–11.

    Article  CAS  PubMed  Google Scholar 

  33. Consonni D, De Matteis S, Pesatori AC, Bertazzi PA, Olsson AC, Kromhout H, Peters S, Vermeulen RC, Pesch B, Bruning T, Kendzia B, Behrens T, Stucker I, Guida F, Wichmann HE, Bruske I, Landi MT, Caporaso NE, Gustavsson P, Plato N, Tse LA, Yu IT, Jockel KH, Ahrens W, Pohlabeln H, Merletti F, Richiardi L, Simonato L, Forastiere F, Siemiatycki J, Parent ME, Tardon A, Boffetta P, Zaridze D, Chen Y, Field JK, t Mannetje A, Pearce N, McLaughlin J, Demers P, Lissowska J, Szeszenia-Dabrowska N, Bencko V, Foretova L, Janout V, Rudnai P, Fabianova E, Stanescu Dumitru R, Bueno-de-Mesquita HB, Schuz J, Straif K. Lung cancer risk among bricklayers in a pooled analysis of case-control studies. Int J Cancer. 2015;136(2):360–71.

    Article  CAS  PubMed  Google Scholar 

  34. Bosetti C, Boffetta P, La Vecchia C. Occupational exposures to polycyclic aromatic hydrocarbons, and respiratory and urinary tract cancers: a quantitative review to 2005. Ann Oncol. 2007;18(3):431–46.

    Article  CAS  PubMed  Google Scholar 

  35. Bolm-Audorff U. Dose response relationship between occupational PAH exposure and lung cancer—an overview. Cent Eur J Public Health. 1996;4(Suppl):40.

    PubMed  Google Scholar 

  36. Singh A, Kamal R, Ahamed I, Wagh M, Bihari V, Sathian B, Kesavachandran CN. PAH exposure-associated lung cancer: an updated meta-analysis. Occup Med (Lond). 2018;68(4):255–61.

    Article  CAS  Google Scholar 

  37. Grimsrud TK, Langseth H, Engeland A, Andersen A. Lung and bladder cancer in a Norwegian municipality with iron and steel producing industry: population based case-control studies. Occup Environ Med. 1998;55(6):387–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. IARC. IARC monographs on the evaluation of carcinogenic risks to humans. Diesel and gasoline engine exhausts and some nitroarenes. International Agency for Research on Cancer. IARC Monogr Eval Carcinog Risks Hum. 1989a;46:1–458.

    Google Scholar 

  39. IARC. Diesel and gasoline engine exhausts and some nitroarenes. Iarc monographs on the evaluation of carcinogenic risks to humans. IARC Monogr Eval Carcinog Risks Hum. 2014;105:9–699.

    Google Scholar 

  40. Silverman DT, Samanic CM, Lubin JH, Blair AE, Stewart PA, Vermeulen R, Coble JB, Rothman N, Schleiff PL, Travis WD, Ziegler RG, Wacholder S, Attfield MD. The diesel exhaust in miners study: a nested case-control study of lung cancer and diesel exhaust. J Natl Cancer Inst. 2012;104(11):855–68.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Tsoi CT, Tse LA. Professional drivers and lung cancer: a systematic review and meta-analysis. Occup Environ Med. 2012;69(11):831–6.

    Article  CAS  PubMed  Google Scholar 

  42. Olsson AC, Gustavsson P, Kromhout H, Peters S, Vermeulen R, Bruske I, Pesch B, Siemiatycki J, Pintos J, Bruning T, Cassidy A, Wichmann HE, Consonni D, Landi MT, Caporaso N, Plato N, Merletti F, Mirabelli D, Richiardi L, Jockel KH, Ahrens W, Pohlabeln H, Lissowska J, Szeszenia-Dabrowska N, Zaridze D, Stucker I, Benhamou S, Bencko V, Foretova L, Janout V, Rudnai P, Fabianova E, Dumitru RS, Gross IM, Kendzia B, Forastiere F, Bueno-de-Mesquita B, Brennan P, Boffetta P, Straif K. Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. Am J Respir Crit Care Med. 2011;183(7):941–8.

    Article  PubMed  PubMed Central  Google Scholar 

  43. IARC. Wood dust. IARC Monogr Eval Carcinog Risks Hum. 1995;62:35–215.

    Google Scholar 

  44. Bhatti P, Newcomer L, Onstad L, Teschke K, Camp J, Morgan M, Vaughan TL. Wood dust exposure and risk of lung cancer. Occup Environ Med. 2011;68(8):599–604.

    Article  PubMed  Google Scholar 

  45. Carosso A, Ruffino C, Bugiani M. Respiratory diseases in wood workers. Br J Ind Med. 1987;44(1):53–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Holmstrom M, Wilhelmsson B. Respiratory symptoms and pathophysiological effects of occupational exposure to formaldehyde and wood dust. Scand J Work Environ Health. 1988;14(5):306–11.

    Article  CAS  PubMed  Google Scholar 

  47. Vallieres E, Pintos J, Parent ME, Siemiatycki J. Occupational exposure to wood dust and risk of lung cancer in two population-based case-control studies in Montreal, Canada. Environ Health. 2015;14:1.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  48. Peters S, Kromhout H, Olsson AC, Wichmann HE, Bruske I, Consonni D, Landi MT, Caporaso N, Siemiatycki J, Richiardi L, Mirabelli D, Simonato L, Gustavsson P, Plato N, Jockel KH, Ahrens W, Pohlabeln H, Boffetta P, Brennan P, Zaridze D, Cassidy A, Lissowska J, Szeszenia-Dabrowska N, Rudnai P, Fabianova E, Forastiere F, Bencko V, Foretova L, Janout V, Stucker I, Dumitru RS, Benhamou S, Bueno-de-Mesquita B, Kendzia B, Pesch B, Straif K, Bruning T, Vermeulen R. Occupational exposure to organic dust increases lung cancer risk in the general population. Thorax. 2012;67(2):111–6.

    Article  PubMed  Google Scholar 

  49. Fritschi L, Fenwick S, Bulsara M. Mortality and cancer incidence in a cohort of meatworkers. Occup Environ Med. 2003;60(9):E4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Guberan E, Usel M, Raymond L, Fioretta G. Mortality and incidence of cancer among a cohort of self employed butchers from Geneva and their wives. Br J Ind Med. 1993;50(11):1008–16.

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Durusoy R, Boffetta P, Mannetje A, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Fabianova E, Cassidy A, Mates D, Bencko V, Salajka F, Janout V, Fevotte J, Fletcher T, Brennan P. Lung cancer risk and occupational exposure to meat and live animals. Int J Cancer. 2006;118(10):2543–7.

    Article  CAS  PubMed  Google Scholar 

  52. Vizcaya D, Christensen KY, Lavoue J, Siemiatycki J. Risk of lung cancer associated with six types of chlorinated solvents: results from two case-control studies in Montreal, Canada. Occup Environ Med. 2013;70(2):81–5.

    Article  PubMed  Google Scholar 

  53. IARC. Occupational exposures in paint manufacture and painting. IARC Monogr Eval Carcinog Risks Hum. 1989b;47:329–442.

    Google Scholar 

  54. Guha N, Merletti F, Steenland NK, Altieri A, Cogliano V, Straif K. Lung cancer risk in painters: a meta-analysis. Environ Health Perspect. 2010;118(3):303–12.

    Article  CAS  PubMed  Google Scholar 

  55. Boffetta P, Hashim D. Exposure to silicon carbide and cancer risk: a systematic review. Int Arch Occup Environ Health. 2017;90(1):1–12.

    Article  CAS  PubMed  Google Scholar 

  56. Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst. 1981;66(6):1191–308.

    Article  CAS  PubMed  Google Scholar 

  57. Dreyer L, Winther JF. Cancer and prevention. Ugeskr Laeger. 2001;163(4):430–8.

    CAS  PubMed  Google Scholar 

  58. Driscoll T, Nelson DI, Steenland K, Leigh J, Concha-Barrientos M, Fingerhut M, Pruss-Ustun A. The global burden of disease due to occupational carcinogens. Am J Ind Med. 2005;48(6):419–31.

    Article  PubMed  Google Scholar 

  59. Boffetta P, Autier P, Boniol M, Boyle P, Hill C, Aurengo A, Masse R, The G, Valleron AJ, Monier R, Tubiana M. An estimate of cancers attributable to occupational exposures in France. J Occup Environ Med. 2010;52(4):399–406.

    Article  CAS  PubMed  Google Scholar 

  60. Wang JB, Fan YG, Jiang Y, Li P, Xiao HJ, Chen WQ, Wei WQ, Zhou QH, Qiao YL, Boffetta P. Attributable causes of lung cancer incidence and mortality in China. Thorac Cancer. 2011;2(4):156–63.

    Article  CAS  PubMed  Google Scholar 

  61. Azevedo ESG, de Moura L, Curado MP, Gomes Fda S, Otero U, Rezende LF, Daumas RP, Guimaraes RM, Meira KC, Leite Ida C, Valente JG, Moreira RI, Koifman R, Malta DC, Mello MS, Guedes TW, Boffetta P. The fraction of cancer attributable to ways of life, infections, occupation, and environmental agents in Brazil in 2020. PLoS One. 2016;11(2):e0148761.

    Article  CAS  Google Scholar 

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Malhotra, J., Boffetta, P. (2020). Epidemiology of Occupational Lung Cancer. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, Cham. https://doi.org/10.1007/978-3-030-30766-0_15

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  • DOI: https://doi.org/10.1007/978-3-030-30766-0_15

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