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Fungal Polyketides: Chemical Diversity and Their Cytotoxic Effects

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Biodiversity and Chemotaxonomy

Part of the book series: Sustainable Development and Biodiversity ((SDEB,volume 24))

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Abstract

Compounds isolated from different natural sources have over the years played crucial roles in the treatment of a wide range of human diseases. Over the past six decades, microorganisms have provided valuable active compounds for the treatment of various diseases. Fungi, in general, produce diverse structural classes of natural products including polyketides, a major class of secondary metabolites obtained from various natural sources‚ which as a group have interesting chemical diversity. In addition, polyketides are known to possess a number of biological and pharmacological effects, viz. cytotoxic, antibacterial, antifungal, antiparasitic, and immunosuppressive effects. In this chapter the focus is on describing the cytotoxic effects of polyketides isolated from fungi and in particular their potential as cancerostatic pharmaceuticals.

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Acknowledgements

The author (HH) thanks the Alexander von Humboldt Foundation for its generous support in providing the opportunity to do work in Germany, which facilitated the writing of this review. The authors want to thank Dr. Abdullah M. Al-Sadi who helped with comments and criticism by reading the manuscript.

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Authors and Affiliations

  1. Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Salle), Germany

    Hidayat Hussain

  2. Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 31806, Brunswick, Germany

    Barbara Schulz

  3. Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, 7600, South Africa

    Ivan R. Green

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  1. Hidayat Hussain
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  2. Barbara Schulz
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  3. Ivan R. Green
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Correspondence to Hidayat Hussain .

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  1. Botany Department, Mohanlal Sukhadia University, Udaipur, India

    Kishan Gopal Ramawat

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Hussain, H., Schulz, B., Green, I.R. (2019). Fungal Polyketides: Chemical Diversity and Their Cytotoxic Effects. In: Ramawat, K. (eds) Biodiversity and Chemotaxonomy. Sustainable Development and Biodiversity, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-030-30746-2_9

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