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A Biofilm-Based Approach to the Diagnosis and Management of Postoperative Spine Infection

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Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors

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Abstract

Postoperative spine infections are a devastating surgical complication. Historical literature reports postoperative infection rates as high as 20%. Improved surgical techniques and the use of intrawound vancomycin powder have dropped rates in recent years. Importantly, patients who experience a postoperative spine infection have a poorer perceived outcome of their surgery even if it is ultimately successful. In an era of patient-reported outcomes (PROs) driving practice patterns and an aging population undergoing increasing rates of high complexity spine surgery, infection, often complicated by biofilms, remains a key target for quality improvement. This article outlines contemporary standard of care practices for the diagnosis and treatment of postoperative spine infection with an emphasis on emerging concepts and broadly applicable surgical techniques including methylene blue staining as a disclosing agent to identify biofilm-burdened regions.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jeremy D. Shaw

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  1. Jeremy D. Shaw
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  1. Department of Veterans Affairs, Department of Orthopaedics, Department of Pathology, Department of Bioengineering, Department of Physical Medicine and Rehabilitation, University of Utah; Uniformed Services University of the Health Sciences, Salt Lake City, Bethesda, UT, USA

    Dustin L. Williams

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Shaw, J.D. (2019). A Biofilm-Based Approach to the Diagnosis and Management of Postoperative Spine Infection. In: Williams, D. (eds) Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors. Springer, Cham. https://doi.org/10.1007/978-3-030-30667-0_8

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