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Catheter-Associated Urinary Tract Infections: Development of a Test Method for Assessing the Efficacy of Antimicrobial Technologies/Products

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Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors

Abstract

Urinary catheters are one of the most commonly utilized medical devices worldwide. They are used in virtually every healthcare setting and contribute to improvements in patient care. While urinary catheters provide invaluable aid to patients, they are not without complications, the most notable being catheter-associated urinary tract infections (CAUTI). Once a urinary catheter is in place, pathogens may migrate to the bladder one of two ways, through the catheter lumen or extraluminally in the periurethral space. In vitro methods are useful tools for predicting clinical efficacy only if they accurately model the most important factors contributing to a clinical infection. Although in vitro methods can’t replace in vivo scenarios, outcomes may be improved as experiments approximate relevant criteria including the biofilm phenotype, time, media type, materials similarities and environment.

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Notes

  1. 1.

    https://www.grandviewresearch.com/industry-analysis/urinary-catheters-market. Accessed June 19, 2018.

  2. 2.

    https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm. Accessed June 19, 2018.

  3. 3.

    https://www.innov-research.com/product/normal-human-urine?c=1 Accessed June 29, 2018.

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Acknowledgments

Darla M. Goeres, Ph.D., holds an Innovation in Regulatory Science Award from BWF.

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  1. Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA

    Jennifer Summers

  2. Center for Biofilm Engineering, Department of Chemical & Biological Engineering, Montana State University, Bozeman, MT, USA

    Darla M. Goeres

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  1. Jennifer Summers
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  2. Darla M. Goeres
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Correspondence to Darla M. Goeres .

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Editors and Affiliations

  1. Department of Veterans Affairs, Department of Orthopaedics, Department of Pathology, Department of Bioengineering, Department of Physical Medicine and Rehabilitation, University of Utah; Uniformed Services University of the Health Sciences, Salt Lake City, Bethesda, UT, USA

    Dustin L. Williams

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Summers, J., Goeres, D.M. (2019). Catheter-Associated Urinary Tract Infections: Development of a Test Method for Assessing the Efficacy of Antimicrobial Technologies/Products. In: Williams, D. (eds) Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors. Springer, Cham. https://doi.org/10.1007/978-3-030-30667-0_3

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