Abstract
The paper consists of the development of a transcutaneous vagal stimulation device triggered by respiration and responsible for monitoring two physiological signals, the Electrocardiogram (ECG) and the Respiratory Cycle (RC). The device is used for some pathologies, such as Alzheimer, obesity and hypertension. The advantages reached by the device include a non-invasive method for vagal modulation and presents the option to synchronize the stimulation with the exhalation phase of RC. It is described the stages of development, which are Recording and Control Interface using an application for mobile devices, Stimulation System for the electrical pulses generation and Synchronization System to trigger the stimulation with the RC wave. In addition, it is shown the device as wearable equipment, by the use of a costumed t-shirt. The results of this development include a validation of the algorithm for peak detection, the pattern of the pulses generated on System Stimulation confirmed and the device is considered as a promising alternative therapy for certain diseases.
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References
Jennum, P., et al.: Welfare consequences for people with epilepsy and their partners: a matched nationwide study in Denmark. Seizure 49, 17–24 (2017)
Lawrence, E., Vegvari, C., Ower, A., Hadjichrysanthou, C., De Wolf, F., Anderson, R.M.: A systematic review of longitudinal studies which measure Alzheimer’s disease biomarkers. J. Alzheimer’s Dis. 59(4), 1359–1379 (2017)
Verrier, R.L., Tan, A.: Heart Rate, Autonomic Markers, and Cardiac Mortality (2009)
Meisenhelter, S., Jobst, B.C.: Neurostimulation for memory enhancement in epilepsy. Curr. Neurol. Neurosci. Rep. 18(6), 1–9 (2018)
Engineer, C.T., et al.: Pairing speech sounds with vagus nerve stimulation drives stimulus-specific cortical plasticity. Brain Stimulation 8(3), 637–644 (2015)
Cyberonics Inc.: Annual Report. VNS therapy system physician’s manual. Houston, TX. http://dynamics.cyberonics.com/manuals. Accessed 25 July 2018
Rush, A.J., et al.: Vagus nerve stimulation for treatment-resistant depression: a randomized controlled acute phase trial. Biol. Psychiatry 58(5), 347–354 (2005)
Clancy, J.A., et al.: Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity. Brain Stimulation 7(6), 871–877 (2014)
Kraus, T., Kiess, O., Hösl, K., Terekhin, P., Kornhuber, J., Forster, C.: CNS BOLD fMRI effects of sham-controlled transcutaneous electrical nerve stimulation in the left outer auditory canal - a pilot study. Brain Stimulation 6(5), 798–804 (2013)
Frangos, E., Ellrich, J., Komisruk, B.R.: Non-invasive access to the vagus nerve central projections via electrical stimulation of the external ear: fMRI evidence in humans. Brain Stimulation 8(3), 624–636 (2015)
Busch, V., Zeman, F., Heckel, A., Menne, F., Ellrich, J., Eich-Hammer, P.: The effect of transcutaneous vagus nerve stimulation on pain perception - an experimental study. Brain Stimulation 6, 202–209 (2013)
Sclocco, R., Garcia, R.G., Gabriel, A., Kettner, N.W., Napadow, V., Barbieri, R.: Respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) effects on autonomic outflow in hypertension. In: 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (2017)
Fisher, H., Stowell, J., Garcia, R., Sclocco, R., Goldstein, J., Napadow, V., Barbieri, R.: Acute effects of respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) in the modulation of blood pressure in hypertensive patients. In: Computing in Cardiology, vol. 45 (2018)
NEMOS® t-VNS for treatment of drug-resistant epilepsy. http://cerbomed.com. Accessed 25 July 2018
Gancheva, S., et al.: Constant hepatic ATP concentrations during prolonged fasting and absence of effects of Cerbomed Nemos® on parasympathetic tone and hepatic energy metabolism. Mol. Metab. 7, 71–79 (2018)
Montano, N., et al.: Heart rate variability explored in the frequency domain: a tool to investigate the link between heart and behavior? Neurosci. Biobehav. Rev. 33, 71–80 (2008)
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Lopes, E.G., Tobaldini, E., Montano, N., Casali, K.R., de Amorim, H.A. (2020). Development of Auricular Transcutaneous Vagal Stimulation Device Integrated with Signal Monitoring. In: González Díaz, C., et al. VIII Latin American Conference on Biomedical Engineering and XLII National Conference on Biomedical Engineering. CLAIB 2019. IFMBE Proceedings, vol 75. Springer, Cham. https://doi.org/10.1007/978-3-030-30648-9_78
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DOI: https://doi.org/10.1007/978-3-030-30648-9_78
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