Abstract
Microvascular perfusion on the foot bottom in 39 subjects (Control group: 23 healthy participants; Patient group: 16 patients with diabetes mellitus) was measured with the laser Doppler flowmetry (LDF). Each subject was requested to perform a non-invasive provocation of 37 min, including 8-min baseline, 3-min ankle occlusion, 6-min post-occlusive reactive hyperemia (PORH), and 20-min heating (42 °C) period. By using the wavelet transform, we calculated the power spectral densities (PSD), on one-minute basis, of the 37-min LDF signal. The results indicated that the PSD corresponding to the endothelial NO-independent (PSDENDO1) and NO-dependent (PSDENDO2) metabolic activities varied with time in both Control and Patient groups. Patient group showed less PSDENDO1 and PSDENDO2 than those in Control group. In summary, endothelial dysfunction in peripheral microcirculation exists in diabetes patients, apparently as compared with healthy participants.
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Acknowledgment
The authors would like to express thanks to the staffs in the Department of Cardiology, I-Da Hospital, Taiwan, for their help and support in performing clinical trials. Also, thanks go to the Ministry of Science and Technology, Taiwan, for its funding support (MOST 105-2221-E-214 -012 -MY3).
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Wang, JJ., Su, XH., Hung, G., He, HY., Tseng, WK. (2020). Quantitative Reduction in the Dynamic Endothelial Function on Foot Microcirculation in Patients with Diabetes Mellitus. In: Lin, KP., Magjarevic, R., de Carvalho, P. (eds) Future Trends in Biomedical and Health Informatics and Cybersecurity in Medical Devices. ICBHI 2019. IFMBE Proceedings, vol 74. Springer, Cham. https://doi.org/10.1007/978-3-030-30636-6_39
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DOI: https://doi.org/10.1007/978-3-030-30636-6_39
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