Abstract
The dynamic roles of photosensitizer (PS) concentration and light intensity were measured and analyzed. The efficacy of photodynamic therapy (PDT) and cell viability (CV) are measured (in vitro) and analyzed by analytic and numerical modeling. For a fixed PS concentration, CV is a nonlinear deceasing function of light intensity and exposure time; for a fixed light intensity, higher PS concentration achieves higher efficacy or smaller CV (at steady-state), in consistent to our analytic formulas. Finally, anti-cancer efficacy may be enhanced by the resupply of PS and/or external oxygen.
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JT Lin is the CEO of New Vision Inc.; KT Chen and HW Liu have no conflict of interest.
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Chen, KT., Lin, JT., Liu, HW. (2020). Empirical Modeling of Photopolymerization for Oxygen-Mediated Anti-cancer. In: Lin, KP., Magjarevic, R., de Carvalho, P. (eds) Future Trends in Biomedical and Health Informatics and Cybersecurity in Medical Devices. ICBHI 2019. IFMBE Proceedings, vol 74. Springer, Cham. https://doi.org/10.1007/978-3-030-30636-6_37
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DOI: https://doi.org/10.1007/978-3-030-30636-6_37
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