Abstract
In this work, the role of the brain extracellular matrix (ECM) in signal processing by a neuronal system is examined. For excitatory postsynaptic currents in the form of Poisson signal, we study the changes of the interspike intervals duration, spike-timing jitter and coefficient of variation in the presence of a background noise with varied intensity. Without ECM impacts, noise-delayed spiking phenomenon reflecting worsening of both reliability and precision of signal processing is revealed. It is shown that, the ECM-neuron feedback mechanism allows enhancing the robustness of neuronal firing in the presence of noise.
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The work was supported by the Ministry of Education and Science of Russia (Project No. 14.Y26.31.0022).
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Rozhnova, M.A., Kazantsev, V.B., Pankratova, E.V. (2020). Brain Extracellular Matrix Impact on Neuronal Firing Reliability and Spike-Timing Jitter. In: Kryzhanovsky, B., Dunin-Barkowski, W., Redko, V., Tiumentsev, Y. (eds) Advances in Neural Computation, Machine Learning, and Cognitive Research III. NEUROINFORMATICS 2019. Studies in Computational Intelligence, vol 856. Springer, Cham. https://doi.org/10.1007/978-3-030-30425-6_22
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DOI: https://doi.org/10.1007/978-3-030-30425-6_22
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