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Autism and Gut–Brain Axis: Role of Probiotics

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Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 24))

Abstract

Characterized by a wide range of behavioural, social and language problems, autism is a complex developmental disability that affects an individual’s capacity to communicate and interact with others. Although the real causes that lead to the development of autism are still unclear, the gastrointestinal tract has been found to play a major role in the development of autism. Alterations in macrobiotic compositions have been reported in autistic children. Irregularities in carbohydrate digestion and absorption could also explain some of the gastrointestinal problems reported in autistic patients, although their role in the neurological and behavioural problems remains uncertain. A relationship between improved gut health and decrease of symptoms in autism has been reported as well. Studies done to evaluate the gluten-free diets, casein-free diets, pre- and probiotic and multivitamin supplementation have shown promising results. Probiotics have been thought to alleviate the progression of autism and reduce cognitive and behavioural deficits.

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Authors and Affiliations

  1. Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, India

    Saravana Babu Chidambaram, Sunanda Tuladhar, Abid Bhat, Arehally Marappa Mahalakshmi, Bipul Ray & Muhammed Bishir

  2. Central Animal Facility, JSS Academy of Higher Education & Research, Mysuru, India

    Saravana Babu Chidambaram, Sunanda Tuladhar, Abid Bhat & Bipul Ray

  3. Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman

    Musthafa Mohamed Essa

  4. Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman

    Musthafa Mohamed Essa

  5. Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

    Srinivasa Rao Bolla

  6. Department of Neurochemistry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India

    Nandakumar Dalavaikodihalli Nanjaiah

  7. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia

    Gilles J. Guillemin

  8. Research & Policy Department, World Innovation Summit for Health (WISH), Qatar Foundation, Doha, Qatar

    M. Walid Qoronfleh

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  1. Saravana Babu Chidambaram
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Editors and Affiliations

  1. Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman

    M. Mohamed Essa

  2. World Innovation Summit for Health WISH, Qatar Foundation, Doha, Qatar

    M. Walid Qoronfleh

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Chidambaram, S.B. et al. (2020). Autism and Gut–Brain Axis: Role of Probiotics. In: Essa, M., Qoronfleh, M. (eds) Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management. Advances in Neurobiology, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-030-30402-7_21

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