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Importance of Nutrition Intervention in Autistic Patients

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Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 24))

Abstract

Along with the issues of inflated social and financial burden associated with autism spectrum disorder (ASD), specific treatment for this disorder has also not been developed. Having a thorough look at previous trials done to treat autism, we find that nutrition intervention had been used frequently as a complementary form of therapy. Indeed, an early diagnosis of nutrition deficiency and metabolic disorders done concomitantly with accurate therapeutic interventions can be a cornerstone for improving cognitive and behavioral aptitudes of people with autism. Several studies have showed that increasing the intake of specific nutrients can reduce the symptoms and comorbidities associated with autism. Consequently, nutrition intervention and appropriate supplementation can be crucial in managing and treating autism. This paper will discuss recent literature on the significance of metabolic aspects in autistic disorder and highlight the influence of nutrition intervention on the symptoms of autism.

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References

  1. World Health Organization. (2010). Mental health: Strengthening our response. Fact Sheet Noe, 220.

    Google Scholar 

  2. Eissa, N., Al-Houqani, M., Sadeq, A., Ojha, S. K., Sasse, A., & Sadek, B. (2018, May 16). Current enlightenment about etiology and pharmacological treatment of autism spectrum disorder. Frontiers in Neuroscience, 12, 304. https://doi.org/10.3389/fnins.2018.00304

    Article  PubMed  PubMed Central  Google Scholar 

  3. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Association.

    Book  Google Scholar 

  4. Folstein, S. E., & Rosen-Sheidley, B. (2001). Genetic of autism: Complex aetiology for a heterogeneous disorder. Nature Reviews Genetics, 2(12), 943–955.

    Article  CAS  PubMed  Google Scholar 

  5. Freitag, C. M. (2007). The genetics of autistic disorders and its clinical relevance: A review of the literature. Molecular Psychiatry, 12(1), 2–22.

    Article  CAS  PubMed  Google Scholar 

  6. Ratajczak, H. V. (2011). Theoretical aspects of autism: Causes–a review. Journal of Immunotoxicology, 8, 68–79.

    Article  PubMed  Google Scholar 

  7. Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C. (2005). Increased excretion of a lipid peroxidation biomarker in autism. Prostaglandins, Leukotrienes & Essential Fatty Acids, 73, 379–384.

    Article  CAS  Google Scholar 

  8. Landrigan, P. J. (2010). What causes autism? Exploring the environmental contribution. Current Opinion in Pediatrics, 22, 219–225.

    Article  PubMed  Google Scholar 

  9. Feucht, S., Ogata, B., & Lucas, B. (2010). Nutrition concerns of children with autism spectrum disorders. Nutrition Focus for Children with Special Health Needs, 25(4), 1–13.

    Google Scholar 

  10. Adams, J. B., & Holloway, C. (2004). Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. The Journal of Alternative and Complementary Medicine, 10, 1033–1039.

    Article  PubMed  Google Scholar 

  11. Mousain-Bosc, M., Roche, M., Polge, A., Pradal-Prat, D., Rapin, J., & Bali, J. P. (2006). Improvement of neurobehavioral disorders in children supplemented with magnesium – Vitamin B6. Magnesium Research, 19, 46–52.

    CAS  PubMed  Google Scholar 

  12. Rossignol, D. A. (2009). Novel and emerging treatments for autism spectrum disorders: A novel systematic review. Annals of Clinical Psychiatry, 21, 213–236.

    PubMed  Google Scholar 

  13. National Center for Biotechnology Information (US). (1998). The NCBI Handbook [Internet]. 2nd edition. Bethesda, MD: National Center for Biotechnology Information (US).

    Google Scholar 

  14. Sikora, D. M., Pettit-Kekel, K., Penfield, J., Merkens, L. S., & Steiner, R. D. (2006). The near universal presence of autism spectrum disorders in children with Smith-Lemli-Opitz syndrome. American Journal of Medical Genetics Part A, 140A, 1511–1518.

    Article  Google Scholar 

  15. Zecavati, N., & Spence, S. J. (2009). Neurometabolic disorders and dysfunction in autism spectrum disorders. Current Neurology and Neuroscience Reports, 9(2), 129–136.

    Article  CAS  PubMed  Google Scholar 

  16. Manzi, B., Loizzo, A. L., Giana, G., & Curatolo, P. (2008). Autism and metabolic diseases. Journal of Child Neurology, 23(3), 307–314.

    Article  PubMed  Google Scholar 

  17. Donlon, J., Levy, H., & Scriver, C. R. (2008). Hyperphenylalaninemia: Phenylalanine hydroxylase deficiency. Online metabolic & molecular bases of inherited disease. New York, NY: McGraw-Hill. (Chapter 77).

    Google Scholar 

  18. Baieli, S., Pavone, L., Meli, C., Fiumara, A., & Coleman, M. (2003). Autism and phenylketonuria. Journal of Autism and Developmental Disorders, 33(2), 201–204.

    Article  PubMed  Google Scholar 

  19. Weber, P., Scholl, S., & Baumgartner, E. R. (2004). Outcome in patients with profound biotinidase deficiency: Relevance of newborn screening. Developmental Medicine & Child Neurology, 46(7), 481–484.

    Article  Google Scholar 

  20. Marcos, J., Guo, L. W., Wilson, W. K., Porter, F. D., & Shackleton, C. (2004). The implications of 7-dehydrosterol-7-reductase deficiency (Smith-Lemli-Opitz syndrome) to neurosteroid production. Steroids, 69(1), 51–60.

    Article  CAS  PubMed  Google Scholar 

  21. Tierney, E., Bukelis, I., Thompson, R. E., Ahmed, K., Aneja, A., Kratz, L., et al. (2006). Abnormalities of cholesterol metabolism in autism spectrum disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B(6), 666–668.

    Article  Google Scholar 

  22. Reichelt, K. L., Hole, K., Hamberger, A., Saelid, G., Edminson, P. D., Braestrup, C. B., et al. (1981). Biologically active peptide-containing fractions in schizophrenia and childhood autism. Advances in Biochemical Psychopharmacology, 28, 627–643.

    CAS  PubMed  Google Scholar 

  23. Kałużna-Czaplińska, J., Zurawicz, E., & Jóźwik, J. (2014). Chromatographic techniques coupled with mass spectrometry for the determination of organic acids in the study of autism. Journal of Chromatography B Analytical Technologies in Biomedical Life Sciences, 964, 128–135.

    Article  CAS  Google Scholar 

  24. Kałużna-Czaplińska, J., Zurawicz, E., Struck, W., & Markuszewski, M. (2014). Identification of organic acids as potential biomarkers in the urine of autistic children using gas chromatography/mass spectrometry. Journal of Chromatography B Analytical Technologies in Biomedical Life Sciences, 966, 70–76.

    Article  CAS  Google Scholar 

  25. Kałużna-Czaplińska, J. (2011). Noninvasive urinary organic acids test to assess biochemical and nutritional individuality in autistic children. Clinical Biochemistry, 44, 686–691.

    Article  CAS  PubMed  Google Scholar 

  26. Reig, M., Molina, D., Loza, E., Ledesma, M. A., & Meseguer, M. A. (1983). Gas-liquid chromatography in routine processing of blood cultures for detecting anaerobic bacteraemia. Journal of Clinical Pathology, 34(2), 189–193.

    Article  Google Scholar 

  27. Clark-Taylor, T., & Clark-Taylor, B. E. (2004). Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenase. Medical Hypotheses, 62(6), 970–975.

    Article  CAS  PubMed  Google Scholar 

  28. Mulloy, A., Lang, R., O’Reilly, M., Sigafoos, J., Lancioni, G., & Rispoli, M. (2010). Gluten-free and casein-free diets in the treatment of autism spectrum disorders: A systematic review. Research in Autism Spectrum Disorders, 4(3), 328–339.

    Article  Google Scholar 

  29. Kałużna-Czaplińska, J., Michalska, M., & Rynkowski, J. (2010). Determination of tryptophan in urine of autistic and healthy children by gas chromatography/mass spectrometry. Medical Science Monitor, 16, 488–492.

    Google Scholar 

  30. Buie, T., Fuchs 3rd, G. J., Furuta, G. T., Kooros, K., Levy, J., Lewis, J. D., et al. (2010). Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics, 125(Suppl. 1), S19eS29. https://doi.org/10.1542/peds.2009-1878

    Article  Google Scholar 

  31. Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011). Gastrointestinal flora and gastrointestinal status in children with autism-comparisons to typical children and correlation with autism severity. BMC Gastroenterology, 16, 11–22. https://doi.org/10.1186/1471-230X-11-22

    Article  Google Scholar 

  32. Denfert, C., & Hube, B. (Eds.). (2007). Candida: Comparative and functional genomics. Wymondham: Caister Academic Press.

    Google Scholar 

  33. Emam, A. M., Mamdouh, M. E., & Abdelrahim, A. S. (2012). Candida albicans infection in autism. Journal of American Science, 8(12), 739.

    Google Scholar 

  34. Shaw, W., Kassen, E., & Chaves, E. (2000). Assessment of antifungal drug therapy in autism by measurement of suspected microbial metabolites in urine with gas chromatography-mass spectrometry. Clinical Practice of Alternative Medicine, 1, 15–26.

    Google Scholar 

  35. Adams, J. B. (2007). Summary of biomedical treatments for autism. San Diego, CA: ARI Publication.

    Google Scholar 

  36. Adams, J. B., Audhya, T., McDonough-Means, S., Rubin, R. A., Quig, D., Geis, E., et al. (2011). Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatrics, 12(11), 111. https://doi.org/10.1186/1471-2431-11-111

    Article  CAS  Google Scholar 

  37. Santhanam, B., & Kendler, B. (2012). Nutritional factors in autism: An overview of nutritional factors in the etiology and management of autism. Integrative Medicine, 11(1), 46–49.

    Google Scholar 

  38. Chez, M. G., Buchanan, C. P., Aimonovitch, M. C., Becker, M., Schaefer, K., Black, C., et al. (2002). Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders. Journal of Child Neurology, 17, 833–837.

    Article  PubMed  Google Scholar 

  39. Xia, W., Zhou, Y., Sun, C., Wang, J., & Wu, L. (2010). A preliminary study on nutritional status and intake in Chinese children with autism. European Journal of Pediatrics, 169, 1201–1206.

    Article  PubMed  Google Scholar 

  40. James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., et al. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American Journal of Clinical Nutrition, 80, 1611–1617.

    Article  CAS  PubMed  Google Scholar 

  41. Mousain-Bosc, M., Roche, M., Rapin, J., & Bali, J. P. (2004). Magnesium VitB6 intake reduces central nervous system hyperexcitability in children. The Journal of the American College Nutrition, 23, 545–548.

    Article  Google Scholar 

  42. Strambi, M., Longini, M., Hayek, J., Berni, S., Macucci, F., Scalacci, E., et al. (2006). Magnesium profile in autism. Biological Trace Element Research, 109, 97–104.

    Article  CAS  PubMed  Google Scholar 

  43. Rimland, B. (2005). Puberty, aggression, and seizures. Autism Research Review International, 19, 3.

    Google Scholar 

  44. Lakshmi Priya, M. D., & Geetha, A. (2011). Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism. Biological Trace Element Research, 142, 148–158.

    Article  CAS  PubMed  Google Scholar 

  45. Kałużna-Czaplińska, J., Michalska, M., & Rynkowski, J. (2011). Homocysteine level in urine of autistic and healthy children. Acta Biochimica Polonica, 58(1), 31e34.

    Article  Google Scholar 

  46. Kałużna-Czaplińska, J., Michalska, M., & Rynkowski, J. (2011). Vitamin supplementation reduces the levels of homocysteine in the urine of autistic children. Nutrition Research, 31, 318–321.

    Article  CAS  PubMed  Google Scholar 

  47. Bralley, J., & Lord, R. (2001). Laboratory evaluations in molecular medicine: Nutrients, toxicants, and cell regulators (pp. 175–208). Norcross, GA: The Institute for Advances in Molecular Medicine. 173e221.

    Google Scholar 

  48. Clarke, C. J., & Haselden, J. N. (2008). Metabolic profiling as a tool for understanding mechanisms of toxicity. Toxicologic Pathology, 36, 140–147.

    Article  CAS  PubMed  Google Scholar 

  49. Lewis, G. D., Asnani, A., & Gerszten, R. E. (2008). Application of metabolomics to cardiovascular biomarker and pathway discovery. Journal of the American College of Cardiology, 52, 117–123.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Williams, T. (2011). Autism spectrum disorders e from genes to environment. Rijeka, Croatia: InTech.

    Book  Google Scholar 

  51. Kałużna-Czaplińska, J., Zurawicz, E., Michalska, M., & Rynkowski, J. (2013). A focus on homocysteine in autism. Acta Biochimica Polonica, 60(2), 137–142.

    Article  PubMed  Google Scholar 

  52. Kruman, I. I., Culmsee, C., Chan, S. L., Kruman, Y., Guo, Z., Penix, L., et al. (2000). Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. The Journal of Neuroscience, 20(18), 6920–6926.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Paşca, S. P., Nemeş, B., Vlase, L., Gagyi, C. E., Dronca, E., Miu, A. C., et al. (2006). High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Science, 78(19), 2244–2248.

    Article  CAS  Google Scholar 

  54. Ali, A., Waly, M. I., Al-Farsi, Y. M., Essa, M. M., Al-Sharbati, M. M., & Deth, R. C. (2011). Hyperhomocysteinemia among Omani autistic children: A case-control study. Acta Biochimica Polonica, 58(4), 547–551.

    Article  CAS  PubMed  Google Scholar 

  55. Shimmura, C., Suda, S., Tsuchiya, K. J., Hashimoto, K., Ohno, K., Matsuzaki, H., et al. (2011). Alteration of plasma glutamate and glutamine levels in children with high-functioning autism. PLoS One, 6(10), 25340. https://doi.org/10.1371/journal.pone.0025340

    Article  CAS  Google Scholar 

  56. Moreno-Fuenmayor, H., Borjas, L., Arrieta, A., Valera, V., & Socorro-Candanoza, L. (1996). Plasma excitatory amino acids in autism. Journal of Clinical Investigation, 37(2), 113–128.

    CAS  Google Scholar 

  57. Aldred, S., Moore, K. M., Fitzgerald, M., & Waring, R. H. (2003). Plasma amino acid levels in children with autism and their families. Journal of Autism and Developmental Disorders, 33(1), 93–97.

    Article  PubMed  Google Scholar 

  58. Arnold, G. L., Hyman, S. L., Mooney, R. A., & Kirby, R. S. (2003). Plasma amino acids profiles in children with autism: Potential risk of nutritional deficiencies. Journal of Autism and Developmental Disorders, 33(4), 449–454.

    Article  PubMed  Google Scholar 

  59. Tu, W. J., Chen, H., & He, J. (2012). Application of LC-MS/MS analysis of plasma amino acids profiles in children with autism. Journal of Clinical Biochemistry and Nutrition, 51(3), 248–249. https://doi.org/10.3164/jcbn.12-45

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Human Nutrition Department, College of Health Sciences, Qatar University, Doha, Qatar

    Tahra ElObeid, Joyce Moawad & Zumin Shi

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  1. Tahra ElObeid
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  2. Joyce Moawad
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  3. Zumin Shi
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Correspondence to Tahra ElObeid .

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Editors and Affiliations

  1. Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman

    M. Mohamed Essa

  2. World Innovation Summit for Health WISH, Qatar Foundation, Doha, Qatar

    M. Walid Qoronfleh

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ElObeid, T., Moawad, J., Shi, Z. (2020). Importance of Nutrition Intervention in Autistic Patients. In: Essa, M., Qoronfleh, M. (eds) Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management. Advances in Neurobiology, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-030-30402-7_18

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