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Socket Malignancy

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Anophthalmia

Abstract

The development of a malignant tumor in an anophthalmic socket is considered a rare entity. Although most anophthalmic patients are closely followed up with frequent visits with ophthalmologists, oculoplastic surgeons, and their ocularists, such entities can be overlooked for long periods of time. Only a handful of cases of malignant tumors originating in the anophthalmic socket, such as ocular surface squamous neoplasia (OSSN) and conjunctival malignant melanoma (MM), have been reported in the literature. However, recurrent malignancies can occur in enucleated, eviscerated, or exenterated sockets, and careful surveillance is needed to detect these tumors early and treat them expeditiously.

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References

  1. Tyers AG, Collin JR. Orbital implants and post enucleation socket syndrome. Trans Ophthalmol Soc U K. 1982;102(Pt 1):90–2.

    PubMed  Google Scholar 

  2. Murchinson AP, Robert Bernardino C. Evaluation of the anophthalmic socket. Rev Ophthalmol. 2006. www.reviewofophthalmology.com/content/d/plastic_pointers/i/1301/c/25050/. Accessed 12 Oct 2018.

  3. Nerad J. Techniques in ophthalmic plastic surgery. 1st ed. Elsevier; 2010. p. 463–486.

    Google Scholar 

  4. Pine K, Sloan B, Stewart J, Jacobs RJ. Concerns of anophthalmic patients wearing artificial eyes. Clin Exp Ophthalmol. 2011;39(1):47–52.

    PubMed  Google Scholar 

  5. American Society of Ocularists. When should you see an ocularist. www.ocularist.org/resources_see_ocularist.asp. Accessed 12 Oct 2018.

  6. Bozkurt B, Akyurek N, Irkec M, Erdener U, Memis L. Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. Clin Exp Ophthalmol. 2007;35(6):535–40.

    Article  PubMed  Google Scholar 

  7. Li Z, Chen L, Qin Z. Paradoxical roles of IL-4 in tumor immunity. Cell Mol Immunol. 2009;6(6):415–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Heidegger I, Hofer J, Luger M, Pichler R, Klocker H, Horninger W, Steiner E, Jochberger S, Culig Z. Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence? Prostate. 2015;75(16):1904–9.

    Article  CAS  PubMed  Google Scholar 

  9. Nolen BM, Lokshin AE. Targeting CCL11 in the treatment of ovarian cancer. Expert Opin Ther Targets. 2010;14(2):157–67.

    Article  CAS  PubMed  Google Scholar 

  10. Newton R, Ziegler J, Ateenyi-Agaba C, Bousarghin L, Casabonne D, Beral V, Mbidde E, Carpenter L, Reeves G, Parkin DM, Wabinga H, Mbulaiteye S, Jaffe H, Bourboulia D, Boshoff C, Touze A, Coursaget P, Uganda Kaposi’s Sarcoma Study Group. The epidemiology of conjunctival squamous cell carcinoma in Uganda. Br J Cancer. 2002;87(3):301–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Newton R, Ferlay J, Reeves G, Beral V, Parkin DM. Effect of ambient solar ultraviolet radiation on incidence of squamous-cell carcinoma of the eye. Lancet. 1996;347(9013):1450–1.

    Article  CAS  PubMed  Google Scholar 

  12. Hwang IP, Jordan DR, Brownstein S, Gilberg SM, McEachren TM, Prokopetz R. Mucoepidermoid carcinoma of the conjunctiva: a series of three cases. Ophthalmology. 2000;107(4):801–5.

    Article  CAS  PubMed  Google Scholar 

  13. Yadav R, Battoo AJ, Mir AW, Haji AG. Bulbar conjunctival metastasis from mucoepidermoid carcinoma of parotid-a case report and review of literature. World J Surg Oncol. 2017;15(1):10.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Hamam R, Bhat P, Foster CS. Conjunctival/corneal intraepithelial neoplasia. Int Ophthalmol Clin. 2009;49(1):63–70.

    Article  PubMed  Google Scholar 

  15. Pe’er J. Ocular surface squamous neoplasia. Ophthalmol Clin North Am. 2005;18(1):1–13, vii.

    Article  PubMed  Google Scholar 

  16. Vargason CW, Mawn LA. Management of inflammation and periocular malignancy in the anophthalmic socket. Int Ophthalmol Clin. 2017;57(1):103–16.

    Article  PubMed  Google Scholar 

  17. Campanella PC, Goldberg SH, Erlichman K, Abendroth C. Squamous cell tumors and ocular prostheses. Ophthalmic Plast Reconstr Surg. 1998;14(1):45–9.

    Article  CAS  PubMed  Google Scholar 

  18. Whittaker KW, Trivedi D, Bridger J, Sandramouli S. Ocular surface squamous neoplasia: report of an unusual case and review of the literature. Orbit. 2002;21(3):209–15.

    Article  PubMed  Google Scholar 

  19. Nguyen J, Ivan D, Esmaeli B. Conjunctival squamous cell carcinoma in the anophthalmic socket. Ophthalmic Plast Reconstr Surg. 2008;24(2):98–101.

    Article  PubMed  Google Scholar 

  20. Espana EM, Levine M, Schoenfield L, Singh AD. Ocular surface squamous neoplasia in an anophthalmic socket 60 years after enucleation. Surv Ophthalmol. 2011;56(6):539–43.

    Article  PubMed  Google Scholar 

  21. Barrett RV, Meyer DR, Carlson JA. Conjunctival squamous cell carcinoma in situ in the anophthalmic socket. Ophthalmic Plast Reconstr Surg. 2010;26(1):52–3.

    Article  PubMed  Google Scholar 

  22. Venkateswaran N, Mercado C, Galor A, Karp CL. Comparison of topical 5-fluorouracil and interferon Alfa-2b as primary treatment modalities for ocular surface squamous neoplasia. Am J Ophthalmol. 2019;199:216–22.

    Article  CAS  PubMed  Google Scholar 

  23. Blasi MA, Maceroni M, Sammarco MG, Pagliara MM. Mitomycin C or interferon as adjuvant therapy to surgery for ocular surface squamous neoplasia: comparative study. Eur J Ophthalmol. 2018;28(2):204–9.

    Article  PubMed  Google Scholar 

  24. Giaconi JA, Karp CL. Current treatment options for conjunctival and corneal intraepithelial neoplasia. Ocul Surf. 2003;1(2):66–73.

    Article  PubMed  Google Scholar 

  25. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology. 1997;104(3):485–92.

    Article  CAS  PubMed  Google Scholar 

  26. Stannard C, Sauerwein W, Maree G, Lecuona K. Radiotherapy for ocular tumours. Eye (Lond). 2013;27(2):119–27.

    Article  CAS  Google Scholar 

  27. Kenawy N, Lake SL, Coupland SE, Damato BE. Conjunctival melanoma and melanocytic intra-epithelial neoplasia. Eye (Lond). 2013;27(2):142–52.

    Article  CAS  Google Scholar 

  28. Scuderi G, Balestrazzi E. Conjunctival melanoma in an anophthalmic orbit. Ophthalmologica. 1973;166(3):172–4.

    Article  CAS  PubMed  Google Scholar 

  29. Mahajan A, Shields CL, Eagle RC Jr, Mashayekhi A, Freire JE, Shields JA. Conjunctival melanoma 3 years after radiation and chemotherapy for retinoblastoma. J Pediatr Ophthalmol Strabismus. 2007;44(5):300–2.

    PubMed  Google Scholar 

  30. Kuo CH, Gao K, Clifford A, Shannon K, Clark J. Orbital exenterations: an 18-year experience from a single head and neck unit. ANZ J Surg. 2011;81(5):326–30.

    Article  PubMed  Google Scholar 

  31. Nemet AY, Martin P, Benger R, Kourt G, Sharma V, Ghabrial R, Danks J. Orbital exenteration: a 15-year study of 38 cases. Ophthalmic Plast Reconstr Surg. 2007;23(6):468–72.

    Article  PubMed  Google Scholar 

  32. Lee PS, Sedrak P, Guha-Thakurta N, Chang EI, Ginsberg LE, Esmaeli B, Debnam JM. Imaging findings of recurrent tumors after orbital exenteration and free flap reconstruction. Ophthalmic Plast Reconstr Surg. 2014;30(4):315–21.

    Article  PubMed  Google Scholar 

  33. Lane KA, Bilyk JR. Preliminary study of positron emission tomography in the detection and management of orbital malignancy. Ophthalmic Plast Reconstr Surg. 2006;22(5):361–5.

    Article  PubMed  Google Scholar 

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Correspondence to Apostolos G. Anagnostopoulos .

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Anagnostopoulos, A.G., Johnson, T.E. (2020). Socket Malignancy. In: Johnson, T. (eds) Anophthalmia . Springer, Cham. https://doi.org/10.1007/978-3-030-29753-4_17

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  • DOI: https://doi.org/10.1007/978-3-030-29753-4_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-29752-7

  • Online ISBN: 978-3-030-29753-4

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